Lumpy Skin Disease in Calves: The Association Between Clinical Signs and Biochemical Alterations

Abstract

| Lumpy skin disease (LSD) is an acute, sub-acute and chronic devastating disease of cattle. The current study was performed to determine various alterations in some haemato-biochemical parameters in calves naturally infected with lumpy skin disease virus (LSDV). Two groups of calves were enrolled in the study. The first group included nine Laboratory confirmed LSDV infected calves and the second group included five healthy calves. Laboratory confirmation was conducted by polymerase chain reaction (PCR) flanking the partial RPO30 gene. Blood samples were collected from all calves and subjected to hematological and biochemical analyses. The total mean leukocytic counts, lymphocytes, and monocytes in the LSDV infected calves were significantly higher than those in the control group. In addition, the total protein, total creatine kinase (CK), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine and potassium levels showed significant high values in LSDV infected calves while cholesterol levels were significantly lowered when compared to healthy ones. Serum gamma glutamyl transferase (GGT) activity, serum albumin, globulins and sodium levels did not show significant difference in calves in different groups. Results of both hematology and biochemistry profiles obtained from calves reflect the severe inflammatory process associated with natural LSD infection.

Epidemiological, Clinico-haemato-biochemical and Molecular Characterization of Lumpy Skin Disease in Cattle

“…There was highly significant increase (P<0.01) in the mean values of body temperature and respiration in LSD affected animals as compared to control whereas significant increase (P<0.05) was observed in the mean values of heart rate in LSD affected cattle (Table 2). Similar findings were reported by Sahoo (2020) and Rouby et al (2021).…”

“…Similar findings were reported by Jalali et al (2017), El-Mandrawy and Alam (2018), Keshta et al (2020) Rouby et al (2021 and Allam et al (2021).…”