1995
DOI: 10.1021/bi00039a033 View full text |Buy / Rent full text
|
|

Abstract: Hormones, growth factors, and other stimuli can generate Ca2+ spikes and waves by activation of the phosphoinositide (PI) pathway. The sources of these Ca2+ signals are inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ stores. Here we use a rapid perfusion apparatus to measure the release of 45Ca2+ from permeabilized rat basophilic leukemia (RBL) cells to investigate the regulation of IP3-mediated Ca2+ release by cytosolic and luminal Ca2+. At 200 nM IP3, Ca2+ release was potentiated by an increase in the cyto… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
2
1
1
1
4
34
0

Year Published

1997
1997
2010
2010

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

4
34
0
Order By: Relevance
“…Evidence that purified IP 3 R1 could be stimulated, but not inhibited, by cytosolic Ca 2þ (Thrower et al 1998;Michikawa et al 1999) raised the possibility that Ca 2þ inhibition might be mediated by an accessory protein, although it has yet to be identified. The same explanation perhaps accounts for some reports, often derived from bilayer recordings, in which Ca 2þ was suggested not to inhibit IP 3 R2 or IP 3 R3 (Horne and Meyer 1995;Hagar et al 1998;Miyakawa et al 1999;Ramos-Franco et al 2000). The balance of opinion, supported by numerous studies of all three IP 3 R subtypes and using both single-channel and Ca 2þ -efflux studies, is that all three IP 3 R subtypes are biphasically regulated by cytosolic Ca 2þ (Marshall and Taylor 1993;Oancea and Meyer 1996;Dufour et al 1997;Missiaen et al 1998;Miyakawa et al 1999;Swatton et al 1999;Boehning and Joseph 2000b;Mak et al 2000;Mak et al 2001;Tu et al 2005a).…”
Section: Regulation Of Ip 3 Receptors By Ca 2þ and Ipmentioning
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Evidence that purified IP 3 R1 could be stimulated, but not inhibited, by cytosolic Ca 2þ (Thrower et al 1998;Michikawa et al 1999) raised the possibility that Ca 2þ inhibition might be mediated by an accessory protein, although it has yet to be identified. The same explanation perhaps accounts for some reports, often derived from bilayer recordings, in which Ca 2þ was suggested not to inhibit IP 3 R2 or IP 3 R3 (Horne and Meyer 1995;Hagar et al 1998;Miyakawa et al 1999;Ramos-Franco et al 2000). The balance of opinion, supported by numerous studies of all three IP 3 R subtypes and using both single-channel and Ca 2þ -efflux studies, is that all three IP 3 R subtypes are biphasically regulated by cytosolic Ca 2þ (Marshall and Taylor 1993;Oancea and Meyer 1996;Dufour et al 1997;Missiaen et al 1998;Miyakawa et al 1999;Swatton et al 1999;Boehning and Joseph 2000b;Mak et al 2000;Mak et al 2001;Tu et al 2005a).…”
Section: Regulation Of Ip 3 Receptors By Ca 2þ and Ipmentioning
“…Stores loaded with Ca 2þ have been shown to become more sensitive to IP 3 in some studies (Missiaen et al 1992;Nunn and Taylor 1992;Oldershaw and Taylor 1993;Parys et al 1993;Missiaen et al 1994;Horne and Meyer 1995;Combettes et al 1996;Tanimura and Turner 1996), but not in others (Combettes et al 1992;Shuttleworth 1992;Combettes et al 1993;van de Put et al 1994). However, even the supportive results do not eliminate the possibility that the increased sensitivity to IP 3 arises from having Ca 2þ pass through active IP 3 R and increase their sensitivity from the cytosolic surface.…”
Section: Regulation Of Ip 3 Receptors By Ca 2þ and Ipmentioning
“…Both the stimulatory and inhibitory effects of Ca 2ϩ were more pronounced at the higher concentration of BAPTA. It is possible that this difference is caused by the postulated local [Ca 2ϩ ] rise in the vicinity of the IP 3 Rs as a result of the passive Ca 2ϩ leak from the stores (17,18). This [Ca 2ϩ ] rise will be less pronounced in the presence of 6 mM BAPTA, thereby reducing the IP 3 -induced Ca 2ϩ release at the lowest Ca 2ϩ concentration from 46.9 Ϯ 2.1 to 30.3 Ϯ 2.3%/2 min (n ϭ 5).…”
Section: Resultsmentioning
“…Some groups (11,17,19,62) believe that luminal Ca 2ϩ binds to a luminal site. Other groups propose a model where luminal Ca 2ϩ leaks out and acts through cytosolic binding sites on the same channel or on closely associated channels (9,20,42). We investigated whether the effect of luminal Ca 2ϩ on the EC 50 and cooperativity of the release (Fig.…”
Section: ] Was Gradually Increased (Closed Circles) or Decreased (Opementioning