Abstract:Roux‐en‐Y gastric bypass surgery (RYGB) provides superior long‐term glycaemic control in severely obese and insulin resistant individuals. The improved peripheral insulin sensitivity at later stages after RYGB has been attributed in part to a reduction in intestinal permeability and associated endotoxemia, but the underlying mechanisms remain unclear. Here, we used diet‐induced obese rat and Caco2 cell monolayer models to show that RYGB region‐specifically strengthens intestinal epithelial barrier (IEB) integr… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.