Lumbar spinal stenosis in a young individual as a result of ligamantum flavum ossification: A case report

Yılmaz, Murat; Kalemcı, Orhan; Yılmaz, Hakan; Palaz, Necdet M.

doi:10.1016/j.ijscr.2013.02.022

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…The MRI provides benefits in detecting the degree of spinal cord compression or accompanying cord edema compared to CT scan 20 . To decipher the exact cause of the neurological deficits of patients and to plan the neurosurgical procedure, obtaining both CT scan and MRI is recommended 2 . Unfortunately, we could not perform MRI due to the metal entrapment within the spinal canal.…”

Section: Discussionmentioning

confidence: 99%

“…LSS makes up for a considerable portion of disability in the senescent population, and it is the most important cause of spinal surgery in patients over 65 years of age 1 . In the youth, LSS is often a result of a hereditary condition that influences the musculoskeletal maturation process, such as scoliosis 2,3 . The condition denotes a restriction in the vertebra, in the regions of the lateral recess, central canal, and the neural foramen.…”

Section: Introductionmentioning

confidence: 99%

“…the musculoskeletal maturation process, such as scoliosis. 2,3 The condition denotes a restriction in the vertebra, in the regions of the lateral recess, central canal, and the neural foramen. Moreover, the stenosis of the lateral recess and neural foramen could prompt the clinical presentation of lumbar radiculopathy in the lumbar area.…”

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confidence: 99%

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Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Zali,

Herfedoust Biazar,

Saleki

et al. 2023

Clinical Case Reports

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Key Clinical MessageLumbar spinal stenosis (LSS) is a prevalent cause of leg and back pain. In the youth, LSS is not common and mainly results from hereditary musculoskeletal disorders. Moreover, spinal fusion is a surgical approach to the treatment of LSS. Entrapment of surgical tools due to breakage is a rare yet important phenomenon in such operations. Therefore, neurological sequelae of these events need to be explored. The case was a 24‐year‐old male complaining of local back pain. Initially, he was diagnosed with LSS at L4 and L5. After the fusion of the vertebrae by the posterior spinal fusion (PSF) method, the patient's pain was resolved. However, the subject complained of worsening local back pain limiting his ability to do routine tasks. A few years later, radiographical evaluations indicated the possible presence of a surgical tool that could not be removed via surgery. During a third operation, the object was removed, and the patient's symptoms recovered. Immediate removal of entrapped surgical objects is necessary due to risks associated with migration and central nervous system damage. Comparing our results to other similar reports, we conclude that in cases of foreign object entrapment, neurological sequelae may be nonexistent or progressively worsen. Also, sequelae emerge either soon after the operation or emerge later. This complicates the diagnosis of such events and the decision of whether to subject the patient to additional neurosurgical operations to remove the tool. These variations may be observed due to the moving of the entrapped tool. Follow‐up of neurological sequelae in spinal surgery patients is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Zali,

Herfedoust Biazar,

Saleki

et al. 2023

Clinical Case Reports

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“…Lumbar spinal stenosis (LSS) is marked by years of progressive pathological narrowing of the spinal canal that imposes increasing pressure on nerve transmission to the lower limbs, which culminates in leg or back pain leading to reduced patients' quality of life, and in severe cases, requires alleviation by surgical intervention 1 . Although LSS can affect the youth, 2 due to its degenerative nature, the incidence of this disease is significantly higher among the elderly population 3 . Lumbar spinal stenosis is considered a global health threat, afflicting approximately 200 thousand adults in the United States 4 ; its morbidity is also elevated in China owing to the increasing aging population 5…”

Section: Introductionmentioning

confidence: 99%

“…can affect the youth, 2 due to its degenerative nature, the incidence of this disease is significantly higher among the elderly population. 3 Lumbar spinal stenosis is considered a global health threat, afflicting approximately 200 thousand adults in the United States 4 ; its morbidity is also elevated in China owing to the increasing aging population.…”

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confidence: 99%

Circular RNA PDK1 targets miR‐4731‐5p to enhance TNXB expression in ligamentum flavum hypertrophy

et al. 2023

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Hypertrophic ligamentum flavum (LF) is a main factor responsible for lumbar spinal stenosis (LSS); however, the exact mechanisms of the pathogenesis of these processes remain unknown. This study aimed to elucidate whether circular RNAs and microRNAs regulate the pathogenesis of LF and LSS, especially focusing on circPDK1 (hsa_circ_0057105), a circRNA targeting pyruvate dehydrogenase kinase 1 and differentially expressed in LF tissues between lumbar disk herniation and LSS patients. The circPDK1/miR-4731 and miR-4731/TNXB (Tenascin XB) interactions were predicted and validated by luciferase reporter assay. Colony formation, woundhealing, and MTT assays were used for estimating cell proliferation and migration.Protein expression levels were evaluated using Western blotting. TNXB expression was verified using immunohistochemistry (IHC). Overexpressing circPDK1 promoted the proliferation, migration, and expression of fibrosis-related protein (alpha smooth muscle actin (α-SMA), lysyl oxidase like 2 (LOXL2), Collagen I, matrix metalloproteinase-2 (MMP-2) and TNXB) in LF whereas miR-4731-5p showed opposite effects. The expression of TNXB was promoted by circPDK1; contrary results were observed with miR-4731-5p. Co-overexpression of miR-4731-5p partially reversed the proliferative and fibrosis-prompting effects of circPDK1 or TNXB. The circPDK1-miR-4731-TNXB pathway may be proposed as a regulatory axis in LF hypertrophy, which might shed light on in-depth research of LSS, as well as providing a novel therapeutic target for LF hypertrophy-induced LSS.

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A clinically relevant MRI grading system for lumbar central canal stenosis

Yuan

Zou

et al. 2016

Clinical Imaging

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Lumbar spinal stenosis in a young individual as a result of ligamantum flavum ossification: A case report

Abstract: Complete relief can be achieved with early and adequate surgery.

Cited by 4 publications

References 22 publications

Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Circular RNA PDK1 targets miR‐4731‐5p to enhance TNXB expression in ligamentum flavum hypertrophy

A clinically relevant MRI grading system for lumbar central canal stenosis

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