Lumbar Puncture Frequency and Cerebrospinal Fluid Analysis in the Neonate

Accuracy of Clinical and Cerebrospinal Fluid Indicators in the Diagnosis of Bacterial Meningitis in Infants <90 Days of Age in Luanda, Angola

“…4 Diagnostic utility of LP for BM in neonates was 5-fold after the first week than during the first week in a study from United States. 19 In our study, weight <2500 g increased the risk of BM—low birth weight is a known risk factor for BM. 20,21 Many other studies have also documented the importance of seizures as a strong sign of BM.…”

Term Newborns Who Are at Risk for Sepsis: Are Lumbar Punctures Necessary?

“…They concluded, as did Eldadah et al 6 in 1987, that LP should be reserved for infants with positive blood cultures, central nervous system symptoms, or positive urine GBS antigen test results. Schwersenski et al 10 showed similar findings, but also noted that the yield of LP increased fivefold when performed in symptomatic infants after the first week of life. Even in the one study 7 that separately analyzed newborns weighing less than 1500 g, only one case of meningitis was found in 773 infants on day 1 of life.…”

Clinical indicators of bacterial meningitis among neonates and young infants in rural Kenya

“…Secondly, our study lacked data on maternal and obstetric factors that might predict meningitis. However, the yield from performing LPs in infants in the first week of life with only maternal risk factors has previously been found to be low [25]. Thirdly, our findings are only from one site.…”