LTCC microreactor for urea determination in biological fluids

Malecha, Karol; Pijanowska, Dorota G.; Gołonka, Leszek; Torbicz, W.

doi:10.1016/j.snb.2009.06.026

Cited by 45 publications

(19 citation statements)

References 23 publications

(25 reference statements)

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“…Low temperature co-fired ceramics Immobilized on commercial glass beads and introduced into the microreactor [108,160]. Poly(acrylonitrile)…”

Section: Magnetic Beadsmentioning

confidence: 99%

“…Bio-microreactors with enzymes immobilized on beads have been prepared by filling the reaction chamber with enzyme-immobilized particles. In this case, various materials were used, such as controlled pore glass [96,[107][108][109], microspheres [110], activated agarose [111,112], and different types of magnetic beads [113][114][115]. Both covalent immobilization and physical interactions have been used in these systems with good results.…”

Section: Magnetic Beadsmentioning

confidence: 99%

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Enzymatic microreactors in biocatalysis: history, features, and future perspectives

Laurenti¹,

Vianna²

2016

Biocatalysis

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Microfluidic reaction devices are a very promising technology for chemical and biochemical processes. In microreactors, the micro dimensions, coupled with a high surface area/volume ratio, permit rapid heat exchange and mass transfer, resulting in higher reaction yields and reaction rates than in conventional reactors. Moreover, the lower energy consumption and easier separation of products permit these systems to have a lower environmental impact compared to macroscale, conventional reactors. Due to these benefits, the use of microreactors is increasing in the biocatalysis field, both by using enzymes in solution and their immobilized counterparts. Following an introduction to the most common applications of microreactors in chemical processes, a broad overview will be given of the latest applications in biocatalytic processes performed in microreactors with free or immobilized enzymes. In particular, attention is given to the nature of the materials used as a support for the enzymes and the strategies employed for their immobilization. Mathematical and engineering aspects concerning fluid dynamics in microreactors were also taken into account as fundamental factors for the optimization of these systems.

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“…Low temperature co-fired ceramics Immobilized on commercial glass beads and introduced into the microreactor [108,160]. Poly(acrylonitrile)…”

Section: Magnetic Beadsmentioning

confidence: 99%

Section: Magnetic Beadsmentioning

confidence: 99%

Enzymatic microreactors in biocatalysis: history, features, and future perspectives

Laurenti¹,

Vianna²

2016

Biocatalysis

View full text Add to dashboard Cite

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“…Other analytes in the biomedical sector include lactate (Kurita et al, 2006;C.Y. Li et al, 2010a), cholesterol (Aravamudhan et al, 2007;Wisitsoraat et al, 2010) and renal markers such as urea Malecha et al, 2009), creatinine (Satoh et al, 2008;Suzuki and Matsugi, 2005), alanine aminotransferase (Song et al, 2009) or glutamic-oxaloacetic transaminase . In food and environmental monitoring, enzymatic biosensing systems have been developed for the detection of fructose (Atalay et al, 2012), lactose in milk (Fornera et al, 2012;Ito et al, 2011), pesticide residues in vegetable and soil samples (Duford et al, 2013) or hypoxanthine to determine the freshness of fish meat (Dolmaci et al, 2012;Lawal and Adeloju, 2010).…”

Section: Applicationsmentioning

confidence: 99%

Microfluidic enzymatic biosensing systems: A review

Mross

Pierrat

Zimmermann

et al. 2015

Biosensors and Bioelectronics

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“…Nowadays, in terms of the extent of technical maturity, industrialization and widespread application, LTCC technology is the mainstream technology in passive integration, 4 and has been more and more widely applied in sensors, actuators and micro systems. 5,6 With rapid development of microelectronics in information technology and the need for miniature, portable, multifunctional, digital, highly reliable and high performance electronics, the requirements for miniaturization, integration and modularization of components become more urgent. LTCC technology is an electronic packaging technology that is used to realize high integration and high performance; in LTCC, the electrode material, substrate and electronic devices are sintered together according to the preliminary design of the structure.…”

Section: Introductionmentioning

confidence: 99%

Measurement of relative permittivity of LTCC ceramic at different temperatures

Tan

Hao

et al. 2014

AIP Advances

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Devices based on LTCC (low-temperature co-fired ceramic) technology are more widely applied in high temperature environments, and the temperature-dependent properties of the LTCC material play an important role in measurements of the characteristics of these devices at high temperature. In this paper, the temperature-dependence of the relative permittivity of DuPont 951 LTCC ceramic is studied from room temperature to 500 °C. An expression for relative permittivity is obtained, which relates the relative permittivity to the resonant frequency, inductance, parasitic capacitance and electrode capacitance of the LTCC sample. Of these properties, the electrode capacitance is the most strongly temperature-dependent. The LTCC sample resonant frequency, inductance and parasitic capacitance were measured (from room temperature to 500 °C) with a high temperature measurement system comprising a muffle furnace and network analyzer. We found that the resonant frequency reduced and the inductance and parasitic capacitance increased slightly as the temperature increases. The relative permittivity can be calculated from experimental frequency, inductance and parasitic capacitance measurements. Calculating results show that the relative permittivity of DuPont 951 LTCC ceramic ceramic increases to 8.21 from room temperature to 500 °C.

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LTCC microreactor for urea determination in biological fluids

Cited by 45 publications

References 23 publications

Enzymatic microreactors in biocatalysis: history, features, and future perspectives

Enzymatic microreactors in biocatalysis: history, features, and future perspectives

Microfluidic enzymatic biosensing systems: A review

Measurement of relative permittivity of LTCC ceramic at different temperatures

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