<title>Optoacoustic imaging of blood for visualization and diagnostics of breast cancer</title>

Abstract

Aggressive malignant tumors may be diagnosed based on relative concentration of oxyhemoglobin and deoxyhemoglobin in the tumor microvasculature. Optoacoustic images of breast cancer and prostate cancer may be acquired at two laser wavelengths matching maximum of oxyhemoglobin (1064-nm, Nd:YAG laser) and deoxyhemoglobin (760-nm, Alexandrite laser). Two optoacoustic systems operating in forward and backward mode respectively for breast cancer and prostate cancer detection, employing arrays of ultravide-band piezoelectric transducers and multichannel electronics was described. After systems testing and calibration in phantoms, initial experiments were performed on patients with suspicious tumors. Quantitative analysis of two-color optoacoustic images was correlated with biopsy and histology. Possibility for tumor differentiation was demonstrated.

Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent

“…5,6 Because of the overwhelming scattering effect of light in biological tissues, the intensity of light, and hence the photoacoustic signal-to-noise ratio (SNR), decreases with depth exponentially with a decay constant of a few millimeters. The attenuation in the intensity of light can be minimized by careful choice of the excitation laser wavelength such that the optical penetration in the tissues is maximized.…”

Whole-body three-dimensional optoacoustic tomography system for small animals

“…10 The high optical contrast between the hemoglobin of blood and the surrounding tissue makes optoacoustic imaging an optimally suited technology for visualization of blood vessels and blood distribution in organs. [11][12][13] Maslov et al 14 and Wang et al 15 have been instrumental in developing an optoacoustic microscope system to image blood vessels in the mouse. Zhang et al have developed a high-resolution 3-D scanning imaging system based on optical interferometry.…”

A Framework of Photo Acoustic Imaging for Ovarian Cancer Detection by Galvo-mirror System

“…Therefore, there is more heat and finally more expansion in tumor tissue in compare with healthy tissue around it [11]. Photoacoustic tomography and photo-acoustic microscopy are two type of Photo-acoustic image [8,12,13]. The steps toward photoacoustic imaging of the targeted area are illustrated in Figure 5.…”