<p>The Anti-Inflammatory Effect of Pistacia Lentiscus in a Rat Model of Colitis</p>

Abstract

Introduction: The mastic tree (Pistacia lentiscus), belonging to the Anacardiaceae family, has anti-inflammatory and antioxidant properties. This study aims to assay the antiinflammatory effects of mastic in rats with colitis. Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups of control, colitis without treatment, colitis with mastic (400 mg/kg/daily) administered orally or intra-rectally, colitis with prednisolone (5 mg/kg of body weight), and colitis with sesame oil for seven successive days. Treatment effects were evaluated by determining cytokines (TNFα, IL6) and myeloperoxidase (MPO) activity, macroscopic scores, and histopathological parameters. The results of each group are compared with colitis without treatment group. Results: After administering sesame oil, the MPO level was reduced significantly compared to colitis without the treatment group (P=0.025). The mastic oil (400 mg/kg orally) administration was effective in reducing colitis severity through the reduction in the total colitis index (p=0.046) after 7 days. The Intra-rectal administration of mastic decreased TNF-α significantly, similar to prednisolone and control groups compared to the colitis without treatment group (p=0.024). The IL-6 did not change in the mastic and sesame oil groups. Conclusion: According to our results, mastic and sesame oil have anti-inflammatory properties, suggesting that they could be used as natural sources to lessen the ulcerative colitis inflammation.

The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines

“…40 g of mastic was dissolved in 200cc sesame oil (in boiling water). Then, the solution was mixed to become uniform [ 13 ]. The dose of mastic oil (400 mg/kg) was chosen based on traditional references [ 12 , 13 ].…”

Beneficial role of Pistacia lentiscus aqueous extract in experimental colitis: anti-inflammatory and potential therapeutic effects

“…Zahouani et al (2020) underlined the anti-in ammatory effect of PLAE oral pre-treatment in acetic acid-induced ulcerative colitis, by reducing IL-6 production. Ostovan et al (2020) showed that PL mastic oil administered intra-rectally signi cantly decreased TNF-α level after 7 days of treatment in acetic acid-induced colitis. Our present nding are also in line with our previous results onethanol-induced gastric ulcer model showing that pre-treatment or treatment with PL fatty oil signi cantly reduced iNOS expression in the gastric mucosa.…”

“…Furthermore, several other studies showed the bene t of Pistacia lentiscus (PL) extracts on ulcerative colitis. Recently, Ostovan et al (2020) demonstrated that Mastic Oil of PL signi cantly reduced the total colitis index, including in ammation severity, in ammation extent, and crypt damage scores. Razi et al (2000) suggested that supplementation with oleogum resin from PL delayed the onset and progression of the disease and helped prevent weight loss in the DSS model of colitis.…”

Effects of sub‐acute co‐exposure to WIFI (2.45 GHz) and Pistacia lentiscus oil treatment on wound healing by primary intention in male rabbits

“…Indeed, pistachio extracts and oil exhibit many beneficial health effects such as antimicrobial, anti-inflammatory, antidiabetic antitumour and antioxidant activities (Abidi et al, 2017;Catalani et al, 2017;Ostovan et al, 2020).…”