<p>Star Circular RNAs In Human Cancer: Progress And Perspectives</p>

Abstract

Circular RNAs (circRNAs) are a recently discovered subclass of non-coding RNAs (ncRNAs) characterized by a covalently closed loop structure created by reverse splicing. Because they do not have a 5ʹ cap structure and a 3ʹ poly A tail, circRNAs have higher stability, abundance and evolutionary conservation than linear RNA between species. These features produce various potential biological functions of circRNAs, such as miRNA sponges, RNA-binding proteins that form RNA protein complexes. In recent years, more and more studies have shown that circRNAs play a vital role in the occurrence and development of human diseases. At the same time, their enormous potential as a biomarker and therapeutic target is also evolving. The purpose of this review is to summarize existing cancer-associated circRNAs and to try to find circRNAs that are abnormally expressed in many cancers. Therefore, we reviewed previous circRNAs studies related to cancer and selected them by statistics. The eight circRNAs that have the highest frequency in different cancers or involve key pathways are called star circRNAs. Here, we review the classification, features, and functions of emerging star circRNAs, with particular attention to the role of circRNAs in various cancers.

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer

“…Circular RNAs (circRNAs), characterized by high stability and conservation, have been increasingly demonstrated to function as the novel promising therapeutic RNA molecules for diverse human diseases, including cancers 27 . Previous studies had shown that several circRNAs correlated with pathogenesis, clinical pathological and prognostic for HCC diagnosis 28, 29 .…”

Hsa_Circ_0054284 Functions as a Tumor Suppressor via The Mir-18a-3p/TIMP2 Pathway in Non–Small-Cell Lung Cancer

“…Some circRNAs can be detected in peripheral blood and can be used as early diagnostic markers for many cancers, including lung cancer [10]. Then, exploring the potential role of circRNAs in cancer may help to verify therapeutic targets and develop new targeted therapeutic drugs [11,12]. However, there are few reports on their role in NSCLC.…”

CircFAM114A2 Inhibits Bladder Cancer Proliferation and Promotes Cisplatin Sensitivity via the miR-222-3p/P27 and miR-146a-5p/P21 Cascades

“…Largely, circRNAs can be organized into ve classes: circRNAs from introns, intergenic circRNAs, exonic circRNAs, exon-intron circRNAs, and antisense circRNAs (7), which are generated from diverse mechanisms including exon skipping, intron pairing and RNA-binding proteins (8). Recently, studies have discovered that circRNAs are intimately related to the incidence and establishment of tumors (7,(9)(10)(11). CircRNAs can perform as competitive endogenous RNAs (ceRNAs) and protect the target mRNA from degradation by sponging microRNA (miRNA) (12).…”