<p>Prostate cancer “super-active surveillance” era opened by vascular targeted photodynamic therapy</p>

Abstract

The “super-active surveillance” concept denotes any active surveillance optimization that allows longer surveillance periods, with the main intention of avoiding overtreatment, by safely eliminating or postponing radical treatment. Super-active surveillance might add to the oncological control with minimal functional impact and similar quality of life compared to active surveillance, which has proved to be safe in well-selected patients. Vascular targeted photodynamic therapy has pioneering shown to significantly reduce the upgrade on subsequent biopsies, resulting in fewer cases converted to radical therapy, and any energy source can be applied to the super-active surveillance concept allowing more men to consider a tissue-preserving therapy for prostate cancer.

Photodynamic Therapy-Adjunctive Therapy in the Treatment of Prostate Cancer

“…Rose Bengal molecules persist inside cells, localizing in endosomes and then undergoing intracellular redistribution to the perinuclear region and finally to the Golgi apparatus and the endoplasmic reticulum (ER) [45]. Rose Bengal is also effective against various bacterial infections and neoplastic cells [46][47][48]. Rose Bengal is characterized by light absorption between 450 and 600 nm [49], and it has a high singlet oxygen quantum yield [50].…”