&lt;p&gt;MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1&lt;/p&gt;

Zhang, Guochao; Zhong, Lele; Luo, Hao; Wang, Shibing

doi:10.2147/ott.s206180

Cited by 32 publications

(39 citation statements)

References 27 publications

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“…miR-155 is previously identified as an oncogenic miRNA in various cancers, such as breast cancer, ovarian cancer and lung cancer. [32][33][34] In our work, we observed that miR-155 was upregulated in both M2 TAMs and exosomes secreted by M2 TAMs. Moreover, the function of exosomes secreted by M2 TAMs in NSCLC metastasis was mediated by miR-155, which modulated RASSF4 in NSCLC cells.…”

Section: Discussionsupporting

confidence: 53%

Tumor-associated macrophages secret exosomal miR-155 to promote metastasis of non-small-cell lung cancer

Chen

et al. 2020

Preprint

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Background: Understanding the molecular basis underlying metastasis of non-small-cell lung cancer (NSCLC) may provide new therapeutic modality for treatment of NSCLC. However, the mechanisms by which tumor-associated macrophages (TAMs) affect NSCLC metastasis still remain undefined. Method: Phenotype of TAMs was identified by flow cytometry. The migration of the tumor cells was detected by transwell assay. Transmission electron microscopy (TEM) and PKH-67 was used to identified and label the exosome. Expression of miR-155 was measured by qRT-PCR. Luciferase analysis, western blot, and rescue assay were used to investigate potential mechanisms of miR-155.Results: We discovered a novel regulatory pathway involved in NSCLC metastasis. We found that M2 TAMs were the main TAMs in metastatic tissues of NSCLC patients and exosomes derived from M2 TAMs were able to promote epithelial-mesenchymal transition (EMT) and migration of NSCLC cells. We demonstrated that miR-155 was abundant in M2 TAMs and exosomes secreted by M2 TAMs. Moreover, we also verified that miR-155 was the key functional biomolecule in exosomes secreted by M2 TAMs. Furthermore, we confirmed that deletion of miR-155 in M2 TAMs could significantly prevent NSCLC metastasis. Overall, Conclusions: we revealed a new regulatory pathway that is M2 TAMs secret exosomal miR-155 to promote NSCLC metastasis. Our findings may provide a practical target for treatment of NSCLC.

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Section: Discussionsupporting

confidence: 53%

Tumor-associated macrophages secret exosomal miR-155 to promote metastasis of non-small-cell lung cancer

Chen

et al. 2020

Preprint

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“…Most of the selected studies agree with the positive correlation between miR-155 overexpression and tumour grade [10,11], Tumour Node Metastasis stage (TNM) [10,12,19] and LN positivity [10,12,19]. Conversely, some discordances emerge about the miR-155 correlation with hormonal receptor status (ER, PR, and HER2).…”

Section: Tissue Mir-155 Versus Patient-and Tumour-related Prognostic mentioning

confidence: 55%

“…In the same study, the univariate analysis demonstrated that miR-155, tumour grade, TNM stage, LN metastases and c-erbB-2 expression were all significantly associated with poor OS, whereas the multivariate analysis identified miR-155 and LN metastases as independent factors for predicting prognosis in BC patients. Similarly, Zhang et al [19] reported a close association between tissue miR-155 overexpression and shorter OS. Differently, Gasparini et al asserted a protective role for miR-155 in TNBC [15,16].…”

Section: Tissue Mir-155 Versus Prognostic Models and Response To Therapymentioning

confidence: 81%

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Grimaldi

Nuzzo

Condorelli

et al. 2020

IJMS

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There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC. Therefore, many researchers have focused on its use as a prognostic biomarker and therapeutic target. However, its prognostic value for BC patients remains controversial. To address this issue, the present systematic review aims to summarize the available evidence and give a picture of a prognostic significance of miR-155 in BC pathology. All eligible studies were searched on PubMed and EMBASE databases through various search strategies. Starting from 289 potential eligible records, data were examined from 28 studies, comparing tissue and circulating miR-155 expression levels with clinicopathological features and survival rates in BC patients. We discuss the pitfalls and challenges that need to be assessed to understand the power of miR-155 to respond to real clinical needs, highlighting the consistency, robustness or lack of results obtained to sate in translating this molecule to clinical practice. Our paper suggests that the prognostic role of miR-155 in the management of BC needs to be further verified.

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“…MiR-155 is previously identi ed as an oncogenic miRNA in various cancers, such as breast cancer, ovarian cancer and lung cancer [35][36][37] . In our work, we observed that miR-155 was up-regulated in both M2 TAMs and exosomes secreted by M2 TAMs.…”

Section: Discussionmentioning

confidence: 99%

Tumor-Associated Macrophages Secret Exosomal miR-155 to Promote Metastasis of Non-Small-Cell Lung Cancer

Chen

et al. 2020

Preprint

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Background: Understanding the molecular basis underlying metastasis of non-small-cell lung cancer (NSCLC) may provide new therapeutic modality for the treatment of NSCLC. However, the mechanisms by which tumor-associated macrophages (TAMs) affect NSCLC metastasis still remain undefined.Methods: The role of macrophages in NSCLC was elucidated by gene set enrichment analysis via The Cancer Genome Atlas database (TCGA) database, and we further verified it through Quantitative real-time PCR and immunohistochemical staining. Exosomes from TAMs were extracted and co-cultured with A549 cells,the biological functions of miR-155 were evaluated through miRNAs sequencing, transwell assays,western blotting,fluorescence labeling,luciferase reporter assay, and animal experiments.Results: We found that M2 TAMs are abundant in metastatic tissues of NSCLC patients and exosomes secreted by M2 TAMs promote epithelial mesenchymal transition(EMT) and migration of A549 cells.Mechanistically,we demonstrated that miR-155 is the biomolecule in exosomes secreted by M2 TAMs and targets 3’-untranslated regions (UTRs) of RASSF4 to promote NSCLC metastasis.Conclusions: MiR-155 is the key functional molecule in M2 TAMs-released exosomes that promote EMT of NSCLC cells through targeting RASSF4. Our study suggests that miR-155 in TAMs and exosomes may serve as a novel therapeutic target in the treatment of lung cancer.

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<p>MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1</p>

Cited by 32 publications

References 27 publications

Tumor-associated macrophages secret exosomal miR-155 to promote metastasis of non-small-cell lung cancer

Tumor-associated macrophages secret exosomal miR-155 to promote metastasis of non-small-cell lung cancer

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Tumor-Associated Macrophages Secret Exosomal miR-155 to Promote Metastasis of Non-Small-Cell Lung Cancer

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