&lt;p&gt;Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis&lt;/p&gt;

Wang, Mina; Liu, Lu; Zhang, Claire Shuiqing; Liao, Ziqi; Jing, Xiang-Hong; Fishers, Marc; Zhao, Luopeng; Xu, Xiaobai; Li, Bin

doi:10.2147/jpr.s247827

Cited by 62 publications

(66 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acupuncture has been used in diabetes for a long time in Asian countries and recent studies have also suggested that acupuncture may alleviate SO (197)(198)(199). A randomized controlled trial, using electrical acupuncture coupled with essential amino acid supplementation to treat SO in male older people, has indicated that both electrical acupuncture with oral essential amino acids group and oral essential amino acids alone group can decrease BF% and increase ASM/H2, with the combination group being more effective than another group.…”

Section: Acupuncturementioning

confidence: 99%

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

et al. 2020

Self Cite

View full text Add to dashboard Cite

Sarcopenic obesity and diabetes are two increasing health problems worldwide, which both share many common risk factors, such as aging, and general obesity. The pathogenesis of sarcopenic obesity includes aging, physical inactivity, malnutrition, low-grade inflammation, insulin resistance, and hormonal changes. Nevertheless, there are two major reasons to cause diabetes: impaired insulin secretion and impaired insulin action. Furthermore, the individual diagnosis of obesity and sarcopenia should be combined to adequately define sarcopenic obesity. Also, the diagnosis of diabetes includes fasting plasma glucose test (FPG), 2-h oral glucose tolerance test (OGTT), glycated hemoglobin (A1C), and random plasma glucose coupled with symptoms. Healthy diet and physical activity are beneficial to both sarcopenic obesity and diabetes, but there are only recommended drugs for diabetes. This review consolidates and discusses the latest research in pathogenesis, diagnosis, and treatments of diabetes and sarcopenic obesity.

show abstract

Section: Acupuncturementioning

confidence: 99%

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…IL-1β is one of the most important pro-inflammatory cytokines in various inflammatory diseases including OA, acting as a trigger of the cascades of inflammatory responses. Also, IL-1β has been demonstrated to have a strong effect on chondrocyte senescence (23). McP-1 also plays a pivotal role in the development of OA by recruiting immune cells and promoting inflammation (24).…”

Section: Discussionmentioning

confidence: 99%

Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1

Wang

Sun

et al. 2021

Int J Mol Med

View full text Add to dashboard Cite

“…Celecoxib has relatively small side effects and is widely used in the treatment of OA [32,33]. In recent years, more and more researches on herbal extracts and dietary supplements have opened up new horizons for the treatment of OA [34][35][36]. Curcumin down-regulates TNF-α by inhibiting the proliferation of macrophages and participates in the activation of brinolysis, so it provides a good complementary therapy for canine OA treatment [11].…”

Section: Paragraphmentioning

confidence: 99%

The Protective Effect of Dietary Administration of Puerarin on Canine Osteoarthritis Model With Anterior Cruciate Ligament Transected

Wen

Song

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundLameness caused by osteoarthritis (OA) is one of the main causes of disability in elderly dogs. Non-steroidal anti-inflammatory drugs (NSAIDs) are important tools in the treatment of canine OA. In recent years, due to the many side effects of NSAIDs, patients cannot tolerate or do not want to take the risk of NSAIDs. People are becoming more and more interested in new treatments for canine OA, and so-called nutritional supplements have emerged. Puerarin has a wide range of pharmacological activities and is often used as a clinical prescription drug and dietary supplement in China. However, the effect of puerarin on canine OA has not been evaluated. Therefore, the purpose of this study is to evaluate the anti-inflammatory and anti-cartilage degradation effects of puerarin in a canine OA model induced by anterior cruciate ligament transection (ACLT), and to detect the serum inflammatory factor interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels and cartilage degradation biomarker C-terminal telopeptides of collagen type II (CTX-II), cartilage oligomeric matrix protein (COMP) and chondroitin sulfate 846 epitope (CS 846) levels in serum and synovial fluid at different periods of puerarin administration. ResultsEight weeks after the administration, the veterinarian performed clinical and imaging evaluations to comprehensively evaluate the protective effect of puerarin on canine OA. Daily oral administration of 20 mg/kg puerarin can significantly inhibit the expression of IL-1β, IL-6 and TNF-α in serum within 8 weeks (P < 0.05), and its anti-inflammatory effect is similar to oral celecoxib (negative control group). Puerarin has a certain protective effect on articular cartilage and can reduce the level of biomarkers CTX-II, COMP and CS 846 in serum and synovial fluid in the early stage of OA (P < 0.05). In addition, the clinical scores and radiographs scores were significantly reduced after 8 weeks of puerarin treatment (P < 0.05). ConclusionsCanine OA cartilage may be mediated through anti-inflammatory, anti-metabolism and anabolic effects, and strongly down-regulate the inflammatory factors IL-1β, IL-6 and TNF-α and cartilage degradation biomarkers CTX-II, COMP and CS 846 are related, providing a good alternative therapy for OA.

show abstract

<p>Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis</p>

Cited by 62 publications

References 70 publications

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1

The Protective Effect of Dietary Administration of Puerarin on Canine Osteoarthritis Model With Anterior Cruciate Ligament Transected

Contact Info

Product

Resources

About