<p><em>CYP2B6</em> genetic polymorphisms influence chronic obstructive pulmonary disease susceptibility in the Hainan population</p>

Abstract

IntroductionChronic obstructive pulmonary disease (COPD) is a lung disease closely related to exposure to exogenous substances. CYP2B6 can activate many exogenous substances, which in turn affect lung cells. The aim of this study was to assess the association of single-nucleotide polymorphisms (SNPs) in CYP2B6 with COPD risk in a Chinese Han population.Materials and methodsGenotypes of the five candidate SNPs in CYP2B6 were identified among 318 cases and 508 healthy controls with an Agena MassARRAY method. The association between CYP2B6 polymorphisms and COPD risk was evaluated using genetic models and haplotype analyses.ResultsIn allele model, we observed that rs4803420 G and rs1038376 A were related to COPD risk. And rs4803420 G/T and G/T-T/T were related to a decreased COPD risk compared to GG genotype in the co-dominant and dominant models, respectively. When comparing with the AA genotype, rs1038376 A/T and A/T-T/T were associated with an increased COPD risk in the co-dominant and dominant models, respectively. Further gender stratification co-dominant and dominant models analysis showed that genotype G/T and G/T-T/T of rs4803420, and genotype A/T and A/T-T/T of rs1038376 were significantly associated with COPD risk compared to the wide type in males and females, while allele C of rs12979270 was only associated with COPD risk in females. Smoking status stratification analysis showed that rs12979270 C was significantly associated with an increased COPD risk under the allele model compared with allele A in the smoking subgroup. Haplotype analysis showed that haplotype GTA and TAA were related to COPD risk.ConclusionOur data is the first to demonstrate that CYP2B6 polymorphisms may exert effects on COPD susceptibility in the Chinese Han population.

SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

“…CYP2B6 rs4803420 G/T was associated with a decreased COPD risk compared to GG genotype, and rs1038376 A/T was related to an increased COPD risk compared with the AA genotype in the co-dominant and dominant models. 29 In the study by Korytina et al demonstrated that rs2787094 and rs2280091 GG haplotypes of ADAM33 gene significantly increased the incidence of COPD. 30 The study of Ding et al found that the genotype TT of IREB2 rs13180 significantly decreased the COPD risk, but failed to find the association between the SNPs with COPD risk in a Han population in the further stratification analysis.…”

Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population

“…The presence of high levels of NNAL in urine was related to the exacerbation of COPD symptoms such as dyspnea, poor functional status, and more restricted activity [ 28 ]. Previously, in the Hainan population of China, polymorphisms in CYP2B6 were related to susceptibility to COPD [ 29 ]. However, in our population, polymorphisms in CYP2B6 and CYP2A6 were associated with a lower risk of suffering from COPD; this indicates that in Latin America, Mexico had a minor prevalence of disease (7.8%) but had an annual cigarette consumption of 500–1499 per person [ 30 ], equal to Brazil, Uruguay, Chile, and Venezuela, which have a major prevalence at 10% [ 31 ].…”

The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people

“…Du et al also showed the genetic variants of GSTP1 , HO-1 , and SOD-3 were correlated with COPD susceptibility [ 7 ]. Besides, other studies have been reported that PDE4D , FAM13A , CYP2B6 gene polymorphisms may exert effects on COPD susceptibility [ 8 – 10 ]. These findings highlighted the important role of genetic polymorphisms in the occurrence of COPD.…”