<p>Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation</p>

Abstract

Aim Renal injury induced by diabetes is reported to be associated with inflammation. Isomangiferin (ISO), a xanthone C-glucoside from the Cyclopia subfamily, exhibits many pharmacological properties. This study aimed to evaluate the protection of ISO against renal damage in diabetic mice. Methods Serum glucose, insulin, uric acid, creatinine, total cholesterol (TC), triglyceride (TG), and inflammatory cytokines in serum and the kidney of db/db diabetes model mice were detected. The components of high mobility group protein B1 (HMGB1)/NACHT leucine-rich repeat- and PYD-containing 3 (NLRP3)/nuclear factor kappa-B (NF-κB) pathway in the kidney were detected by Western blot and immunohistochemical analysis. Results ISO improved lipid profile and glucose tolerance, and inhibited the production of inflammatory cytokines in a db/db model mice. Moreover, ISO decreased biochemical indexes in the serum and inhibited the activation of HMGB1/NLRP3/NF-κB signaling in the kidney of db/db model mice. Conclusion ISO provides protection against renal injury via inhibiting HMGB1/NLRP3/NF-κB signaling in a diabetic mouse model.

Targeting HMGB1: A Potential Therapeutic Strategy for Chronic Kidney Disease

“…Gly can also prevent tacrolimus-induced renal injury by improving lysosomal function and regulating autophagy 148 . Many other natural products, such as Korea red ginseng 121 , Bupleurum polysaccharides 149 , Dioscin 150 , 151 , Plantago asiatica L 152 , Isomangiferin 153 , Troxerutin 154 , and Ellagic acid 155 , have been found to have similar therapeutic effects on CKD.…”

“…Bupleurum polysaccharides [149], Dioscin [150,151], Plantago asiatica L [152], Isomangiferin [153], Troxerutin [154], and Ellagic acid [155], have been found to have similar therapeutic effects on CKD.…”

Exploring the Use of Iris Species: Antioxidant Properties, Phytochemistry, Medicinal and Industrial Applications

“…Flavonoids are the most abundant group of phenolic compounds in the genus Iris. They are mainly represented by flavones and flavone glycosides (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28), isoflavones , flavanols , flavan-3-ols (104, 105), dihydroflavonol (107), flavanonol (110)(111)(112)(113), xanthones (114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129)(130) and anthocyanins (131)(132)(133)(134)(135)(136)(137)(138)(139)(140) [79,…”

“…Similarly, xanthones (114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129)(130) are flavonoid compounds that exist in a substantial amount in the rhizomes, roots, leaves and flowers of several Iris spp., including I. pallida Lam., I. hungarica Waldst. & Kit, I. sibirica L., I. variegata L. and I. humilis Georgi [75,[100][101][102][103].…”