&lt;p&gt;Hsa_circ_0000069 Knockdown Inhibits Tumorigenesis and Exosomes with Downregulated hsa_circ_0000069 Suppress Malignant Transformation via Inhibition of STIL in Pancreatic Cancer&lt;/p&gt;

Ye, Zhenyu; Zhu, Zhaobi; Xie, Jiaming; Feng, Zhenyu; Li, Yecheng; Xu, Xiangrong; Li, Wei; Chen, Wei

doi:10.2147/ijn.s279258

Cited by 49 publications

(41 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On a final note, researchers recently suggested that sEV-ncRNAs might contribute to the malignant transformation of benign pancreatic tissue. PDAC sEVs were shown to contain high levels of circRNA-0000069 that upon transfer to benign human pancreatic duct epithelial cells induced the expression of transcription factor STIL, entailing enhanced cell proliferation, migration, and cell cycle progression [59]. However, the relevance of this observation remains uncertain due to the experimental setting in which rapidly proliferating tumor cells served as sEV donors.…”

Section: Proliferation Invasion Emt and Metastasismentioning

confidence: 99%

Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

Reese

Dhayat

2021

J Hematol Oncol

View full text Add to dashboard Cite

Pancreatic cancer has the worst prognosis among common tumors which is attributed to its aggressive phenotype, diagnosis at advanced, inoperable stages, and resistance to systemic therapy. Non-coding RNAs (ncRNAs) such as microRNAs, long non-coding RNAs, and circular RNAs have been established as important regulators of gene expression and their deregulation has been implicated in multiple diseases and foremost cancer. In the tumor microenvironment, non-coding RNAs can be distributed among cancer cells, stromal cells, and immune cells via small extracellular vesicles (sEVs), thereby facilitating intercellular communication and influencing major cancer hallmarks such as angiogenesis, evasion of the immune system, and metastatic dissemination. Furthermore, sEV-ncRNAs have shown promising potential as liquid biopsies with diagnostic and prognostic significance. In this review, we summarize the role of sEVs as carriers of ncRNAs and underlying molecular mechanisms in pancreatic cancer. Moreover, we review the potential of sEV-ncRNAs as biomarkers and highlight the suitability of sEVs as delivery vehicles for ncRNA-based cancer therapy.

show abstract

Section: Proliferation Invasion Emt and Metastasismentioning

confidence: 99%

Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

Reese

Dhayat

2021

J Hematol Oncol

View full text Add to dashboard Cite

show abstract

“…Moreover, YBX1 is upregulated in various malignant tumors, including pancreatic cancer, and is involved in tumor cell invasion and chemoresistance. [74][75][76] Furthermore, Ye et al 77 found that downregulation of hsa_-circ_0000069 markedly suppressed the expression of its parental gene, SCL/TAL1 interrupting locus (STIL) and inhibited the proliferation, migration, and invasion of pancreatic cancer cells. These studies suggest that circRNA can be more powerful than just a miRNA sponge in pancreatic cancer.…”

Section: Other Effects Of Circrna and Pancreatic Cancermentioning

confidence: 99%

Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

Sun¹,

Chen²,

Ge³

et al. 2021

CMAR

View full text Add to dashboard Cite

There are few biomarkers available for the early diagnosis and prognostic evaluation of pancreatic cancer. In addition, the development of targeted therapy for pancreatic cancer is an unmet need due to the lack of molecular targets. With the continuous progress in circular RNA (circRNA)-related research, its role in the occurrence and development of pancreatic cancer has been discovered and gradually recognized. Therefore, circRNA may represent a novel marker for early diagnosis of this disease and a focus of targeted clinical therapy. CircRNA is a type of non-coding RNA with a closed circular structure formed by covalent bonds. Some circRNAs can act as “sponges” to adsorb microRNAs (miRNAs) and play the role of competitive endogenous RNA (ceRNA) to remove their inhibitory effects on the target genes of miRNA. Thus, they can indirectly restore the expression of target genes. The circRNA–miRNA–mRNA network plays a regulatory role in the proliferation, invasion, metastasis, and other biological behaviors of pancreatic cancer. Given the recent advances in circRNA, this review seeks to provide an overview of the biological function of circRNA and highlights the recent research progress regarding the molecular mechanism of circRNA for the clinical diagnosis and treatment of pancreatic cancer.

show abstract

“…They were also correlated with PDA cell repopulation and recurrence following irradiation of PDA patients with a specific correlation of hsa_circ_0002130-hsa_miR_4482-3p-NBN interaction network, modulating metabolic process and lysine degradation [ 37 ]. A recent study from Ye et al further revealed that PDA tumor cells-derived EVs transferred specific circRNAs such as Hsa_circ_0000069, favoring malignant transformation as well as proliferation and migration processes through upregulation of STIL [ 38 ]. In the highly invasive subset of liver metastases PDA-EVs, circRNA PDE8A was found in superior quantities, and its expression in PDA patient plasma-derived EVs was associated with greater lymphatic invasion and a higher TNM stage.…”

Section: Tumor Cells Evs-mediated Crosstalkmentioning

confidence: 99%

The Cellular and Biological Impact of Extracellular Vesicles in Pancreatic Cancer

Hussain

Nigri

Tomasini

2021

Cancers

View full text Add to dashboard Cite

Deciphering the interactions between tumor and stromal cells is a growing field of research to improve pancreatic cancer-associated therapies and patients’ care. Indeed, while accounting for 50 to 90% of the tumor mass, many pieces of evidence reported that beyond their structural role, the non-tumoral cells composing the intra-tumoral microenvironment influence tumor cells’ proliferation, metabolism, cell death and resistance to therapies, among others. Simultaneously, tumor cells can influence non-tumoral neighboring or distant cells in order to shape a tumor-supportive and immunosuppressive environment as well as influencing the formation of metastatic niches. Among intercellular modes of communication, extracellular vesicles can simultaneously transfer the largest variety of signals and were recently reported as key effectors of cell–cell communication in pancreatic cancer, from its development to its evolution as well as its ability to resist available treatments. This review focuses on extracellular vesicles-mediated communication between different cellular components of pancreatic tumors, from the modulation of cellular activities and abilities to their biological and physiological relevance. Taking into consideration the intra-tumoral microenvironment and its extracellular-mediated crosstalk as main drivers of pancreatic cancer development should open up new therapeutic windows.

show abstract

<p>Hsa_circ_0000069 Knockdown Inhibits Tumorigenesis and Exosomes with Downregulated hsa_circ_0000069 Suppress Malignant Transformation via Inhibition of STIL in Pancreatic Cancer</p>

Cited by 49 publications

References 45 publications

Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

The Cellular and Biological Impact of Extracellular Vesicles in Pancreatic Cancer

Contact Info

Product

Resources

About