&lt;p&gt;Factors Influencing Participation Of Healthy Volunteers In Clinical Trials: Findings From A Cross-Sectional Study In Delhi, North India&lt;/p&gt;

Ranjan, Rajesh; Agarwal, Nidhi; Kapur, Prem; Marwah, Amit; Parveen, Rizwana

doi:10.2147/ppa.s206728

Cited by 13 publications

(8 citation statements)

References 30 publications

(41 reference statements)

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“…Several participants in this study mentioned access to free full medical check-ups as one of the advantages of participating in the clinical trial. The results of this study are consistent with other studies exploring the motivation factors for healthy participants to take part in clinical trials [ 51 , 54 ]. Many of these participants considered the medical check-up performed as a requirement for the Phase I screening process for the early phase clinical trials a benefit because it confirms their health status.…”

Section: Discussionsupporting

confidence: 91%

Motivations and barriers for healthy participants to participate in herbal remedy clinical trial in Tanzania: A qualitative study based on the theory of planned behaviour

et al. 2022

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Background The success of any randomized clinical trial relies on the willingness of people to be recruited in the trial. However, 90% of all clinical trials worldwide have been reported to have failed to recruit the required number of trial participants within the scheduled time. This study aimed to qualitatively explore the motivations and barriers for healthy participants to participate in herbal remedy clinical trials in Tanzania. Materials and methods This study used a qualitative descriptive research design based on the theory of planned behaviour. A total of five Focus Group Discussions (FGD) were conducted at Bagamoyo Clinical Trial Facility from 29 to 30 May 2021. Each group consisted of 5 to 10 participants. The participants of the study were 30 healthy males aged 18 to 45 male who participated in the clinical trial that evaluated the safety, tolerability, and efficacy of Maytenus Senegalensis. The focus group discussions were recorded audio-recorded. Verbatim transcription and thematic analysis were performed on the data. Results The prominent motivations mentioned were the opportunity for self-development, altruism, flexible study visit schedule, and financial compensation. Furthermore, the Participants’ mothers and friends were reported as those most likely to approve of participation in an herbal remedy. The most mentioned barriers were inconvenience related to time commitment requirements, possible side effects, inflexible study visit schedule, and having other commitments. Moreover, the participants’ father was reported to be more likely to disapprove of participation in a clinical trial of herbal remedy clinical trial. Conclusions The results of this study showed that the motivations and barriers of healthy participants to participate in clinical trials of herbal remedies are varied and that participants are motivated by more than financial gains. The identified motivations and barriers can be used as a guideline to improve the design of recruitment and retention strategies for herbal remedy clinical trials.

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Section: Discussionsupporting

confidence: 91%

Motivations and barriers for healthy participants to participate in herbal remedy clinical trial in Tanzania: A qualitative study based on the theory of planned behaviour

et al. 2022

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“…Similarly, financial compensation was reported an encouraging factor for those that previously participated in a CT, while it does not affect the attitudes of participation-naïve individuals. 26,27 In the present study, the results demonstrated confidence of respondents in the Jordanian healthcare system and being comfortable from their physician's positive belief in a CT. A moderate positive correlation was found in the current study between knowledge and perception in regards to CTs. Jordan has a well-developed and reputable healthcare system, attributed mainly to the relative high physician to population ratio and the well-equipped hospitals.…”

Section: Discussionsupporting

confidence: 60%

“…Detailed analysis demonstrated respondents that previously took part in a CT were more affected by financial compensation compared with those that never participated (data not shown). Similarly, financial compensation was reported an encouraging factor for those that previously participated in a CT, while it does not affect the attitudes of participation‐naïve individuals 26,27 …”

Section: Discussionmentioning

confidence: 99%

Clinical trials: Predictors of knowledge and attitudes towards participation

2020

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Aims Clinical trials (CTs) are critical to advancing of patient care. Understanding the public's knowledge and the attitudes towards participating in CTs is important for their successful implication. In Jordan this data are currently not available. The present study aimed to explore the knowledge, attitude and perception of Jordanians towards CTs participation. Methods A cross‐sectional study was conducted on 1216 Jordanians recruited from public hospitals and pharmaceutical research centres. Results About 20.5% of the respondents have previously participated in a CT. About 68.3% and 50.1% had good knowledge and positive attitude towards CTs, respectively. Good knowledge was associated with male gender (OR = 1.696, 95% CI = 1.284‐0.240, P < .001), higher education (OR = 1.433, 95% CI = 1.107‐1.856, P = .006) and healthy condition (OR = 1.822, 95% CI = 1.234‐2.690, P = .003); while older age was associated with a poor knowledge (OR = 0.985, 95% CI = 0.972‐0.998, P = .026). Female gender (OR = 1.817, 95% CI = 1.406‐2.349, P < .001), higher education (OR = 1.294, 95% CI = 1.017‐1.646, P = .036) and previous participation (OR = 1.919, 95% CI = 1.388‐2.653, P < .001) were factors predicting the positive attitudes. A very weak positive correlation was found between knowledge and attitude (Spearman's r = 0.074, P = .01). Regarding perceptions, most of the respondents (85.3%) perceive that CTs are conducted in an ethical manner in Jordan, only 52.9% however feel comfortable towards participation. A moderate positive correlation was found between knowledge and perception (Spearman's r = 0.275, P < .001). Taking part in a CT significantly affect knowledge, attitudes and perceptions. Conclusions This study revealed important insights regarding knowledge, attitudes and perception of Jordanians towards CTs. Educational interventions can improve awareness of the ethical standards under which CTs are conducted affecting the perception to participate. Promotion of CTs among patients and healthy individuals is needed to increase participation.

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“…Finally, factors such as age (Sheikh & Mattingly, 1981;Teschke et al, 2010;Van Wieren-de Wijer et al, 2009), race/ethnicity (Braunstein et al, 2008;Liu et al, 2019;Milani et al, 2020;Shavers et al, 2002;Webb et al, 2019;Wendler et al, 2006), time constraints (Markanday et al, 2013;Stuart et al, 2019), and financial compensation (Bentley & Thacker, 2004;Ding et al, 2007;Grady, 2005;Ranjan et al, 2019) sometimes correlate with or impact willingness to participate in research. Future research can examine if these factors also influence participation in specific ESS procedures and if they interact with sex to impact participation.…”

Section: Future Researchmentioning

confidence: 99%

Volunteer Bias and Female Participation in Exercise and Sports Science Research

Nuzzo

2021

Quest

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In 1973, Harriet Williams published in Quest on volunteer bias (selfselection bias) in kinesiology research. Williams' evidence-based commentary included a discussion on sex differences in volunteerism. More recently, some exercise and sports scientists (ESS) have suggested investigator bias explains the lower proportion of female than male participants in ESS research. Here, I explain volunteer bias warrants consideration in contemporary discussions on female participation in ESS research. I discuss sex differences in willingness to participate in certain research and how this corresponds to sex differences in personality traits and interests. I explain that sex differences in disease prevalence and physical activity participation also likely contribute to sex differences in ESS research participation. I conclude that, moving forward, evidence-based historical interpretations of female participation in ESS research are required, and future research should seek to establish a causal model of ESS research participation that considers both investigator and volunteer bias.

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<p>Factors Influencing Participation Of Healthy Volunteers In Clinical Trials: Findings From A Cross-Sectional Study In Delhi, North India</p>

Cited by 13 publications

References 30 publications

Motivations and barriers for healthy participants to participate in herbal remedy clinical trial in Tanzania: A qualitative study based on the theory of planned behaviour

Motivations and barriers for healthy participants to participate in herbal remedy clinical trial in Tanzania: A qualitative study based on the theory of planned behaviour

Clinical trials: Predictors of knowledge and attitudes towards participation

Volunteer Bias and Female Participation in Exercise and Sports Science Research

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