&lt;p&gt;Evaluation of Wound Healing Activity of &lt;em&gt;Salvia haenkei&lt;/em&gt; Hydroalcoholic Aerial Part Extract on in vitro and in vivo Experimental Models&lt;/p&gt;

Scrima, Mario; Melito, Carmela; Merola, Filomena; Iorio, Antonio; Vito, Nicoletta; Giori, Andrea Maria; Ferravante, Angela

doi:10.2147/ccid.s224418

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…Considering that several plants from the genus Salvia have been reported as wound healing agents [ 27 , 35 , 36 ], we hypothesise that S. cacaliifolia could promote wound healing. For that we resorted to the scratch assay and wound closure was assessed in the presence and absence of the essential oil in fibroblasts.…”

Section: Resultsmentioning

confidence: 99%

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Alves-Silva

Cocco

Piras

et al. 2023

Plants

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Salvia is widely recognized for its therapeutic potential. However, the biological relevance of some species remains unknown, namely Salvia cacaliifolia Benth. Therefore, the aim of this study is to unveil the chemical composition and relevant properties to its essential oil (EO). The EO was characterized by GC and GC-MS and its antifungal effect was evaluated according to the CLSI guidelines on dermatophytes and yeasts. The anti-inflammatory potential was assessed on lipopolysaccharide-stimulated macrophages, by assessing the production of nitric oxide (NO) and the effect on the protein levels of two key pro-inflammatory enzymes, iNOS and COX-2 by western blot analysis. Wound healing capacity was determined using the scratch wound healing assay, and the anti-aging potential was assessed by evaluating the senescence marker β-galactosidase. The EO was mainly characterized by γ-curcumene, β-bisabolene, bicyclogermacrene and curzerenone. It is effective in inhibiting the growth of dermatophytes and C. neoformans. The EO significantly decreased iNOS and COX-2 protein levels and concomitantly reduced NO release. Additionally, it demonstrated anti-senescence potential and promoted wound healing. Overall, this study highlights relevant pharmacological properties of the EO of Salvia cacaliifolia, which should be further explored envisaging the development of sustainable, innovative, and environmentally friendly skin products.

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Section: Resultsmentioning

confidence: 99%

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Alves-Silva

Cocco

Piras

et al. 2023

Plants

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“…Numerous investigations have established the influence of S. officinalis on wound healing [ 220 , 221 , 222 , 223 , 224 ]. Farahpour et al [ 222 ] demonstrated that 2% and 4% ( w / w ) topical ointments of sage oil on mouse full-thickness cutaneous wounds dramatically decreased pro-inflammatory cytokines and the overall bacteria count when compared to a control group [ 222 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

et al. 2022

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Wound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal products. The aim of the present study is to summarize the most recent in vitro, in vivo, and clinical studies on major herbal preparations, their phytochemical constituents, and new formulations for wound management. Research reveals that several herbal medicaments have marked activity in the management of wounds and that this activity is ascribed to flavonoids, alkaloids, saponins, and phenolic compounds. These phytochemicals can act at different stages of the process by means of various mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulating, cell proliferation, and angiogenic effects. The application of natural compounds using nanotechnology systems may provide significant improvement in the efficacy of wound treatments. Increasing the clinical use of these therapies would require safety assessment in clinical trials.

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Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review

Mssillou

Bakour

Slighoua

et al. 2022

Journal of Ethnopharmacology

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<p>Evaluation of Wound Healing Activity of <em>Salvia haenkei</em> Hydroalcoholic Aerial Part Extract on in vitro and in vivo Experimental Models</p>

Cited by 7 publications

References 29 publications

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review

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