&lt;p&gt;Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes&lt;/p&gt;

Al‐Aama, Jumana Y.; Mahdi, Hadiah Bassam Al; Salama, Mohammed A.; Bakur, Khadija; Alhozali, Amani; Mosli, Hala H.; Bahijri, Suhad; Bahieldin, Ahmed; Willmitzer, Lothar; Edris, Sherif

doi:10.2147/dmso.s215528

Cited by 14 publications

(9 citation statements)

References 53 publications

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“…Conversely, mannan degradation was markedly decreased. Of interest, serum fucose levels are higher in the T2DM patients compared to healthy cohorts [ 35 ]. Mannan-oligosaccharide in the diet improves the metabolic syndrome in mice, alternatively insulin resistance and dyslipidemia [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

The role of the gut microbiota on the metabolic status of obese children

et al. 2021

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Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator. Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5–15 years) were divided into three groups: metabolically healthy obese (MHO, n = 42), metabolic unhealthy obese (MUO, n = 23), and healthy normal weight controls (Con, n = 21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO group, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, LBP was positively correlated with genus Roseburia and Faecalibacterium, and negatively correlated with genus Lactobacillus, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p < 0.05). Conclusion Although there are distinct differences in the characteristic gut microbiota of the MUO population versus MHO, dysbiosis of gut microsystem is already extant in the MHO cohort. The abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds, suggesting that dysbiosis of gut microbiota, present in the MHO children, conceivably serves as a compensatory or remedial response to a surfeit of nutrients.

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Section: Discussionmentioning

confidence: 99%

The role of the gut microbiota on the metabolic status of obese children

et al. 2021

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“…Thus, elucidating the potential mechanism and identifying potential biomarkers for risk stratification of dysglycemia in CAD is of great clinical importance for disease early diagnosis and prevention. Several studies have revealed the decreased betaine in patients with diabetes than those without [ 32 , 33 ]. So far, no study has discussed the association of circulating betaine with the presence of dysglycemia in CAD.…”

Section: Discussionmentioning

confidence: 99%

Association between plasma betaine levels and dysglycemia in patients with coronary artery disease

et al. 2020

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Background: Dietary betaine intake was reported to associate with favorable profile of metabolic disorders. However, the role of circulating betaine in coronary artery disease (CAD) patients with dysglycemia is still unknown. This study aimed to investigate the potential associations between plasma betaine levels and dysglycemia in CAD patients. Methods: Total 307 subjects were enrolled in this study with 165 CAD patients (57 with dysglycemia and 108 with normal glycemia) and 142 age and sex matched controls (CON). Fasting plasma betaine were detected using liquid chromatography tandem mass spectrometry. Results: Plasma betaine were lower in normal glycemia CAD patients (28.29(22.38-35.73) μM) compared with healthy controls (29.75(25.32-39.15) μM), and were further decreased in CAD patients with dysglycemia (24.14(20.84-30.76) μM, p < 0.01). Betaine levels were inversely correlated with fasting glucose, glycated hemoglobin%, diastolic blood pressure, triglyceride and alanine aminotransferase levels (all, p ≤ 0.05). Subjects in the highest betaine tertile group had lowest frequency of CAD and dysglycemia (all, p < 0.01). Increased betaine levels were independently associated with low risk of dysglycemia in CAD after adjustment for multiple traditional risk factors (OR = 0.04, 95%CI: 0-0.37, p = 0.01). Furthermore, betaine had good performance at distinguishing CAD with dysglycemia from normal glycemia CAD (AUC = 0.62, p < 0.01). Conclusion: Plasma betaine levels are independently and inversely associated with dysglycemia in CAD after adjustment for multiple factors, and may be useful for risk stratification of dysglycemia in CAD.

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“…Thus, elucidating the differences of onset mechanism between T2D and CAD, and identifying sensitive biomarkers for risk predicting of T2D in CAD is of great clinical importance for disease early diagnosis and prevention. Several studies have revealed the decreased betaine in patients with diabetes than those without [32,33]. So far, no study has discussed the association of circulating betaine with risk of T2D in CAD.…”

Section: Discussionmentioning

confidence: 99%

Low serum betaine levels as a potential biomarker for type 2 diabetes mellitus in patients with coronary artery disease

Guo

Qiu

Zhu

et al. 2020

Preprint

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Background Dietary betaine intake was reported to associate with improved metabolic profile in type 2 diabetes (T2D). However, the role of circulating betaine in coronary artery disease (CAD) patients with T2D is still unknown. This study aimed to investigate the potential role of serum betaine as a potential biomarker for T2D risk in CAD patients. Methods Total 307 subjects were enrolled with 165 CAD patients (57 with T2D and 108 without) and 142 age and sex matched controls (CON). Fasting serum betaine were detected using liquid chromatography tandem mass spectrometry. Results Serum betaine were lower in simple CAD patients compared with healthy controls, and were further decreased in CAD patients with T2D. Betaine was inversely associated with fasting glucose. Subjects in the highest betaine tertile group had lower triglycerides, total cholesterol and low-density lipoprotein as well was lower percentage of CAD and T2D. Increased betaine in CAD was independently associated with low risk of T2D. Furthermore, betaine was a potential diagnostic marker in distinguishing simple CAD from CAD with T2D. Conclusion Low levels of betaine are associated with increased risk of CAD and T2D in CAD, and could be a biomarker for predicting T2D in CAD.

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<p>Detection of Secondary Metabolites as Biomarkers for the Early Diagnosis and Prevention of Type 2 Diabetes</p>

Cited by 14 publications

References 53 publications

The role of the gut microbiota on the metabolic status of obese children

The role of the gut microbiota on the metabolic status of obese children

Association between plasma betaine levels and dysglycemia in patients with coronary artery disease

Low serum betaine levels as a potential biomarker for type 2 diabetes mellitus in patients with coronary artery disease

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