2020
DOI: 10.2147/ijn.s251269
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Abstract: Background: Large-scale production and application of amorphous silica nanoparticles (SiNPs) have enhanced the risk of human exposure to SiNPs. However, the toxic effects and the underlying biological mechanisms of SiNPs on Caenorhabditis elegans remain largely unclear. Purpose: This study was to investigate the genome-wide transcriptional alteration of SiNPs on C. elegans. Methods and Results: In this study, a total number of 3105 differentially expressed genes were identified in C. elegans. Among them, 1398 … Show more

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Cited by 8 publications
(3 citation statements)
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“…The control group was cultured with an equivalent volume of PBS, adding inactivated resting cells. The OD 660 of the experimental groups were subtracted from those of the control groups to remove the effect of abiotic factors [ 40 ]. The SMX detection method was based on Yu et al [ 25 ].…”
Section: Methodsmentioning
confidence: 99%
“…The control group was cultured with an equivalent volume of PBS, adding inactivated resting cells. The OD 660 of the experimental groups were subtracted from those of the control groups to remove the effect of abiotic factors [ 40 ]. The SMX detection method was based on Yu et al [ 25 ].…”
Section: Methodsmentioning
confidence: 99%
“…Total 23 differentially expressed microRNA, including cel-miR-85-3p, cel-miR-793, cel-miR-241-5p and cel-miR-5549-5p, can regulate longevity-related pathways and inflammatory signaling pathways. In addition, SiNPs can disrupt motor behavior and reduce lifespan by activating ins-7, daf-16, ftt-2, fat-5 and rho (Liang 2020). SiNPs can impair the intestinal absorption of oligopeptides in the intestine.…”
Section: Accepted Articlementioning
confidence: 99%
“…These include cel‐mir‐85‐3p, cel‐mir‐793, cel‐mir‐241‐5p, and cel‐mir‐5549‐5p. In addition, SiNPs can disrupt motor behavior and reduce life span by activating insulin‐related 7 (ins‐7), daf‐16, fourteen‐three‐three 2 (ftt‐2), fatty acid desaturase 5 (fat‐5), and rho (Liang et al 2020). The SiNPs can impair the intestinal absorption of oligopeptides in the intestine.…”
Section: Nonmetallic Nmsmentioning
confidence: 99%