&lt;p&gt;Combination of the preoperative albumin to globulin ratio and neutrophil to lymphocyte ratio as a novel prognostic factor in patients with triple negative breast cancer&lt;/p&gt;

Xuan, Qijia; Yang, Yan; Ji, Hongfei; Tang, Shuli; Zhao, Juan; Shao, Jiayue; Wang, Jingxuan

doi:10.2147/cmar.s195324

Cited by 28 publications

(26 citation statements)

References 34 publications

(30 reference statements)

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“…Liu et al reported that inflammatory and nutritional markers were independent predictive indexes for the survival of gastric cancer patients (14). Combined indexes of inflammation and nutrition, such as PNI (18,32), SIS (22,33), and AGR (16,34) have been proved to be related to survival in cancers. Consistently, our study suggested that low level of PNI and AGR and high level of SIS had poor OS and DFS in NPC patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

et al. 2020

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Inflammation and nutritional status have significant effects on the prognosis of cancer patients. This study investigated the predictive value of clinical biochemistry-based indexes in nasopharyngeal carcinoma (NPC). This retrospective study included 559 NPC patients and 500 patients with chronic rhinitis. Continuous variables were measured by t-test. The area under curves (AUC) was used to determine the diagnostic and prognostic value for NPC. Kaplan-Meier methods and the log-rank test were used to analyze overall survival (OS) and disease-free survival (DFS) of the patients. Cox and logistic regression analysis were used to analyze the independent prognostic risk factors for survival and influencing factors of side effects after treatment, respectively. The study results revealed that most indexes of NPC and rhinitis were significantly different between the two groups. In the survival analysis, the systemic inflammation score (SIS), prognostic nutritional index (PNI), albumin/globulin ratio (AGR), albumin (ALB), urea nitrogen (BUN) and creatinine (CREA) had significant influence on the OS and DFS. AGR was the optimal prognostic indicator for NPC. Among these indexes, SIS, AGR, BUN and CERA were independent prognostic factors of OS, AGR and PNI were independent prognostic factors of DFS. Most indexes were risk factors of side effects occurred in radiotherapy. In conclusion, the clinical biochemistry-based indexes, are reliable and of low-cost, therefore, they can be used in predicting diagnosis, prognosis and treatment plans of NPC.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

et al. 2020

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“…Neutrophils could inhibit cytotoxic lymphocytes through the release of arginase, reactive oxygen species and nitric oxide. Lymphocyte counts indicate anti-tumor immunity [13]. A previous study con rmed that ganoderma spore powder inhibits the production of TNF-α and IL-6 preventing sustained immune response [32].…”

Section: Discussionmentioning

confidence: 98%

“…These analyses demonstrated that activated molecules are differentially associated with cytokine production following drug stimuli suggesting a high possibility for effective evaluation of overall immune status. [13,22], Kaplan-Meier univariate survival analysis of AGR and NLR detection in each group showed that AGR, as well as PFS were positively correlated amongst breast cancer and lung cancer patients (HR = 1.572, P = 0.038). NLR was shown to be negatively correlated with PFS (HR = 2.064, P = 0.042), as shown in Fig.…”

Section: Exploratory Analysis Of T Cell Subset Associations With Cytomentioning

confidence: 97%

“…Recently, in ammation-associated biomarkers have attracted major attention as predictive tools in cancers including parameters such as neutrophil-lymphocyte ratio (NLR) and albumin-to-globulin ratio (AGR) [13][14]. In this study, we aimed to determine the impact of G. lucidum spore treatment on key immunological biomarkers including T cell subpopulations, cytokine levels, AGR and NLR in lung and breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Biomarkers Indicate Immunological Benefits Provided by Ganoderma Spore Powder in Post-Operative Breast and Lung Cancer Patients: A Prospective Clinical Trial

Deng

Tang

et al. 2020

Preprint

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Background: T lymphocyte subsets with correlative cytokines, albumin to globulin ratio (AGR) and neutrophil to lymphocyte ratio (NLR), have been linked to inflammatory indicators of immune response and prognosis in various cancer types. The aim of this study was to determine the utility of these biomarkers in predicting the immunological benefits of Ganoderma spore powder in post-operative patients with breast and lung cancer. Methods: We prospectively evaluated 120 consecutive breast and lung cancer patients with or without Ganoderma spore powder. T lymphocyte subsets, as well as relative cytokines were detected and assessed by Pearson correlation analysis. The relationships between AGR and NLR with ganoderma spore powder treatment and prognosis were analyzed using Kaplan–Meier and Cox regression methods.Results: The prevalence of CD3+, CD4+ and CD4+/CD8+, CD3+HLADR-, CD4+HLADR- and CD8+HLADR- cell types was higher in the ganderma spore treated group compared to untreated controls. In addition, the percentage of CD4+CD25+Treg, CD3+HLADR+, CD4+HLADR+ and CD8+HLADR+ cell types was lower in the treated group. IL-2 and IL-12 frequencies were significantly higher during the treatment period which negatively impacted levels of IL-10. Other immunosuppressive factors such as COX2, TGF- 1 and HIF-1A had higher prevalence in non-treated patients. Correlation analysis showed several correlations between the biomarkers, specifically between IL-6 and TGF- 1, CD28 and IL-12R, TGF- 1 and Foxp3, IL-10 and IL-12R with COX2, Foxp3 and CD8, IL-10 and CD28 with IL-12R, COX2 and CD8, IL-12R with COX2, CD3 with CD4 and CD8. A positive relationship was also observed between IL-2 and TGF- 1. Conversely, IL-2 was negatively related to CD3, and HIF-1 negatively related with CD4, CD28 and CD3. Kaplan–Meier analysis suggested that low AGR/high NLR was related to poor progression free survival (PFS, HR=1.572, P=0.038/HR=2.064, P=0.042). A combination of high AGR and low NLR that predicted treatment benefits was also associated with PFS (HR=0.661, P=0.033/HR=1.044, P=0.048).Conclusions: Our findings show that T lymphocyte subsets predominately combined with relevant cytokines and AGR/NLR inflammatory predictors may help to identify patients most likely to benefit from the immunological enhancements from Ganoderma spore powder treatment.

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“…Widmann et al first reported the correlation between the NLR and BC prognosis in 316 patients, and it was found that a higher NLR (≥3.3) before treatment was an adverse factor for both short-and long-term mortality (15). The majority of retrospective studies thereafter have drawn similar conclusions (16)(17)(18)(19), and the NLR was found to be consistent among different BC subtypes at baseline (20,21). However, a prospective substudy of GEICAM/9906, which comprised 1,246 patients, did not find any prognostic value of the NLR after adjustment for clinicopathological factors; in addition, a high NLR was independently associated with worse DFS in only highrisk patients (the hormone receptor-negative/HER2+ population and in patients with ≥3 lymph node metastases) (22).…”

Section: Prognostic Value Of the Neutrophil-to-lymphocyte Ratio (Nlr)mentioning

confidence: 96%

A Rosetta Stone for Breast Cancer: Prognostic Value and Dynamic Regulation of Neutrophil in Tumor Microenvironment

et al. 2020

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Increasing evidence has revealed that the initiation and progression of breast cancer are greatly affected by the immune environment. Neutrophils are the most abundant leucocytes in circulation and act as the spearhead in inflammation, including in breast cancer. Circulating neutrophils are closely related to the prognosis of breast cancer patients, and tumor-infiltrating neutrophils have varied functions at different stages of breast cancer, such as antitumor or tumor-promoting neutrophils, which are termed N1 and N2 neutrophils, respectively. In this review, we will discuss the utility of circulating neutrophils for predicting prognosis and therapeutic efficacy and the underlying mechanisms of their chemotaxis, the dynamic regulation of their antitumor or protumor functions and their different spatial distributions in tumor microenvironment. Finally, we also discuss the possibility of targeting neutrophils as a therapeutic strategy in breast cancer.

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<p>Combination of the preoperative albumin to globulin ratio and neutrophil to lymphocyte ratio as a novel prognostic factor in patients with triple negative breast cancer</p>

Cited by 28 publications

References 34 publications

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma

Dynamic Biomarkers Indicate Immunological Benefits Provided by Ganoderma Spore Powder in Post-Operative Breast and Lung Cancer Patients: A Prospective Clinical Trial

A Rosetta Stone for Breast Cancer: Prognostic Value and Dynamic Regulation of Neutrophil in Tumor Microenvironment

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