<p>A review of the application of cellulose hemostatic agent on trauma injuries</p>

Abstract

Introduction: Planning for management of bleeding in trauma injuries is very important. The initial purpose in emergency situations should be immediate establishment of an efficient hemostasis, principally in its topical application. In this study, we aimed to review the major relevant articles in the case of application of cellulose hemostatic agent on trauma injuries. Methods: We searched the online databases such as PubMed, MEDLINE, Wiley, EMBASE, ISI Web of Knowledge, and Scopus. Two reviewers independently searched and assessed the titles and abstracts of all articles. Results: Upon screening the titles and abstracts, 24 studies were identified for full-text review. The oxidized cellulose had the best clotting times, while it demonstrated low absorption ability. Surgical and thermosensitive chitosan hemostatic could be valuable for managing hemorrhage from liver injuries in trauma patients. Conclusion: Recently, the application of cellulose hemostatic agents has been one of the main improvements obtained for controlling bleeding in trauma injuries. However, generally according to the literature review, the decision about using each agent should be made on a case-by-case basis. However, it can be mentioned that the perfect hemostatic agent has not been still identified.

A resorbable hyaluronic acid hydrogel to prevent adhesion in porcine model under laparotomy pelvic surgery

“…10 Finally, because oxidized regenerated cellulose is used in close proximity to blood vessels, it can lead to scar contractions that affect blood flow. 11 HA is synthesized endogenously in vertebrates without immunogenic, toxic, and proinflammatory properties. Furthermore, it can be degraded to fragments by endogenous hyaluronidase and then absorbed by cells.…”

“…10 Oxidized regenerated cellulose is used in close proximity to the blood vessels and might lead to scar contractions, affecting blood flow. 11…”

“…10 Oxidized regenerated cellulose is used in close proximity to the blood vessels and might lead to scar contractions, affecting blood flow. 11 HA is present in all vertebrates and ubiquitous uronic acid composed of repeating units of disaccharides of D-glucuronic acid and N-acetylglucosamine connected via β-1,3 and β-1,4 glycosidic bonds. 12 HA forms a distinct tertiary structure in aqueous solution and demonstrates moisturizing capability.…”

Liver trauma in the intensive care unit

“…Operative management of liver injury often includes an exploratory laparotomy to identify and control the source of hemorrhage. Minor bleeding, usually associated with a grade I or II liver injury, can be controlled with manual compression or packing, cautery, argon, or topical hemostatic agents such as Surgicel [3,12]. It is notable that Surgicel and similar agents can have abscess-like appearance on CT, and can be misleading: communication with the surgeon on methods used for hemostatic control is paramount [13].…”

Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material

“…At the same time, it can also activate the coagulation pathway in the blood to accelerate wound hemostasis [ 16 , 17 ]. Currently, the most commonly used commercially available cellulose hemostat is in the form of “oxidized regenerated cellulose (ORC),” which, according to a few studies, demonstrates the best clotting time [ 18 , 19 ].…”