&lt;em&gt;SIRT1&lt;/em&gt; gene polymorphisms and risk of lung cancer

Lv, Yanbo; Lin, Shuangyan; Peng, Fang

doi:10.2147/cmar.s142677

Cited by 16 publications

(10 citation statements)

References 43 publications

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“…SIRT1 rs3758391 was reported to be more common in Egyptian breast cancer patients than controls, as was rs12778366 46 . Rs12778366 was also one of the SIRT1 variants analyzed in a Chinese study on lung cancer risk, but this study showed no significant associations 47 . Lung cancer differs etiologically from CRC, making a comparison with these results more difficult, but (postmenopausal) breast cancer shares several risk factors with CRC, including body fatness 41 .…”

Section: Discussioncontrasting

confidence: 60%

Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study

Simons

Schouten

Godschalk

et al. 2018

Sci Rep

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Sirtuin 1 (SIRT1) is an energy-sensing protein, which may affect tumorigenesis. We used SIRT1 variants as time-independent indicators of SIRT1 involvement in carcinogenesis and we studied two tagging SIRT1 variants in relation to colorectal cancer (CRC) risk. We also evaluated known energy balance-related CRC risk factors within SIRT1 genotype strata. The Netherlands Cohort Study includes 120,852 individuals and has 20.3 years follow-up (case-cohort: nsubcohort = 5000; nCRC cases = 4667). At baseline, participants self-reported weight, weight at age 20, height, trouser/skirt size reflecting waist circumference, physical activity, and early life energy restriction. SIRT1 rs12778366 and rs10997870 were genotyped in toenail DNA available for ~75% of the cohort. Sex- and subsite-specific Cox hazard ratios (HRs) showed that the rs12778366 CC versus TT genotype decreased CRC and colon cancer risks in women (HRCRC = 0.53, 95% confidence interval: 0.30–0.94) but not men. Multiplicative interactions were observed between SIRT1 variants and energy balance-related factors in relation to CRC endpoints, but the direction of associations was not always conform expectation nor specific to one genotype stratum. In conclusion, these results support SIRT1 involvement in colon cancer development in women. No conclusions could be made regarding a modifying effect of SIRT1 variants on associations between energy balance-related factors and CRC risk.

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Section: Discussioncontrasting

confidence: 60%

Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study

Simons

Schouten

Godschalk

et al. 2018

Sci Rep

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“…These factors are essential for not only initiation and progression, but also metastasis of cancers ( 116 , 117 ). Mutations and extensive polymorphisms of SIRT1 were found in Chinese and Japanese ( 118 – 121 ) and 41 cancer lines ( 122 ). Although the data on mutations and polymorphisms of SIRT1 are very limited, we speculate that difference in SIRT1 mutations and polymorphisms may be one of accounts for difference in predicting OS and TNM stage and lymphatic metastasis of cancer by SIRT1 expression.…”

Section: Discussionmentioning

confidence: 99%

Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis

Sun

Zhang

et al. 2019

Front. Endocrinol.

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Background: Silent information regulator 2 homolog 1 (SIRT1) is an evolutionarily conserved enzymes with nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase activity. SIRT1 is involved in a large variety of cellular processes, such as genomic stability, energy metabolism, senescence, gene transcription, and oxidative stress. SIRT1 has long been recognized as both a tumor promoter and tumor suppressor. Its prognostic role in cancers remains controversial.Methods: A meta-analysis of 13,138 subjects in 63 articles from PubMed, EMBASE, and Cochrane Library was performed to evaluate survival and clinicopathological significance of SIRT1 expression in various cancers.Results: The pooled results of meta-analysis showed that elevated expression of SIRT1 implies a poor overall survival (OS) of cancer patients [Hazard Ratio (HR) = 1.566, 95% CI: 1.293–1.895, P < 0.0001], disease free survival (DFS) (HR = 1.631, 95% CI: 1.250–2.130, P = 0.0003), event free survival (EFS) (HR = 2.534, 95% CI: 1.602–4.009, P = 0.0001), and progress-free survival (PFS) (HR = 3.325 95% CI: 2.762–4.003, P < 0.0001). Elevated SIRT1 level was associated with tumor stage [Relative Risk (RR) = 1.299, 95% CI: 1.114–1.514, P = 0.0008], lymph node metastasis (RR = 1.172, 95% CI: 1.010–1.360, P = 0.0363), and distant metastasis (RR = 1.562, 95% CI: 1.022–2.387, P = 0.0392). Meta-regression and subgroup analysis revealed that ethnic background has influence on the role of SIRT1 expression in predicting survival and clinicopathological characteristics of cancers. Overexpression of SIRT1 predicted a worse OS and higher TNM stage and lymphatic metastasis in Asian population especially in China.Conclusion: Our data suggested that elevated expression of SIRT1 predicted a poor OS, DFS, EFS, PFS, but not for recurrence-free survival (RFS) and cancer-specific survival (CCS). SIRT1 overexpression was associated with higher tumor stage, lymph node metastasis, and distant metastasis. SIRT1-mediated molecular events and biological processes could be an underlying mechanism for metastasis and SIRT1 is a therapeutic target for inhibiting metastasis, leading to good prognosis.

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“…[ 40 ] Lv and colleagues suggested that rs3758391 had no significant association with susceptibility of different lung cancer subtype. [ 41 ] T allele of rs3758391 was positively correlated with nephritis in patients with systemic lupus erythematosus. [ 42 ]…”

Section: Discussionmentioning

confidence: 99%

Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity

Peng¹,

Zhang²,

Tang³

et al. 2018

Medicine

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The present study aimed to explore the influence of sirtuin 1 (SIRT1) polymorphisms (rs12778366 and rs3758391) on diabetic foot (DF) susceptibility and severity in patients with type 2 diabetes mellitus (T2DM).This case–control study recruited 142 patients with DF, 148 patients with T2DM, and 148 healthy controls. SIRT1 gene polymorphisms were sequenced by polymerase chain reaction (PCR) and direct sequencing method. The relative expression of SIRT1 mRNA was estimated using quantitative real-time PCR (qRT-PCR) assay. Odds ratio (OR) with 95% confidence interval (95% CI) were used to represent the association of SIRT1 polymorphisms with DF susceptibility and severity. The results were adjusted using logistic regression analysis.C allele of rs12778366 polymorphism was significantly correlated with reduced DF susceptibility which deriving from healthy controls (adjusted OR = 0.364, 95% CI = 0.158–0.835) so was patients with T2DM (P = .047, OR = 0.591, 95%CI = 0.349–0.998), but the results became nonsignificant adjusted by clinical features (adjusted OR = 0.654, 95% CI = 0.391–1.094). We failed to find any significant association between rs3758391 polymorphisms and T2DM, DF susceptibility. No significant association has been discovered between SIRT1 polymorphisms and DF severity or characteristics. In addition, compared to healthy control and T2DM cases, patients with DF exhibited significant downregulation of SIRT1. The 2 studied polymorphisms had no effects on its gene expression (P > .05 for all).SIRT1 rs12778366 polymorphism C allele might act as a protective factor for DF onset.

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<em>SIRT1</em> gene polymorphisms and risk of lung cancer

Cited by 16 publications

References 43 publications

Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study

Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study

Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis

Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity

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