<b> COLONIZATION PREVALENCE AND SUSCEPTIBILITY OF Streptococcus agalactiae IN PREGNANT WOMEN AT HUSM </b>

Abstract

The Streptococcus agalactiae colonization prevalence and its susceptibility to antimicrobials in pregnant women at University Hospital of Santa Maria (HUSM) were evaluated from June to December 2009. The vaginal-rectal material was inoculated into tubes containing Todd-Hewitt broth with subsequent subculture on blood agar. The GBS identification was made through presumptive tests, confirmed by serological test and its susceptibility was evaluated. The occurrence ofGBS maternal-fetal transmission in the colonized pregnant women was researched. The GBS colonization was 11.11%. All strains were susceptible to penicillin, ampicillin, and vancomycin. Two strains (50%) were intermediate to clindamycin and one (25%) intermediate to erythromycin. A newborn whose mother was colonized had early-onset neonatal infection by GBS. By this, it is very important the research about the colonization by GBS in all pregnant women from 35 to 37 weeks of gestation and the use of intrapartum antibiotic prophylaxis for colonized pregnant women.Descriptors: Streptococcus agalactiae; Prevalence; Pregnant women; Newborns; Microbial Sensitivity Tests. RESUMOAvaliou-se a prevalência de colonização pelo Streptococcus agalactiae e o seu perfil de sensibilidade frente aos antimicrobianos em gestantes no Hospital Universitário de Santa Maria (HUSM), de junho a dezembro de 2009. O material vaginal-retal foi inoculado em tubos contendo caldo Todd-Hewitt com posterior subcultura em ágar sangue. A identificação do EGB foi realizada através de testes presuntivos, confirmadas por teste sorológico e avaliado seu perfil de sensibilidade. Pesquisou-se ocorrência de transmissão materno-fetal do EGB nas gestantes colonizadas. A prevalência de colonização foi de 11,11%. Todas as cepas foram sensíveis à penicilina, ampicilina e vancomicina. Duas cepas (50%) foram intermediárias à clindamicina e uma (25%) intermediária à eritromicina. Um recém-nascido de mãe colonizada teve infecção neonatal de início precoce por EGB. Confirma-se a importância da pesquisa de colonização por EGB em todas as gestantes entre 35ª e 37ª semana de gestação e uso de quimioprofilaxia intraparto nas gestantes colonizadas.

PREVALÊNCIA DA COLONIZAÇÃO POR Streptococcus agalactiae EM GESTANTES ATENDIDAS NA REDE PÚBLICA DE SAÚDE DE SANTO ÂNGELO – RS

“…9,10 Em outros países esse percentual se mantém, como por exemplo, em uma pesquisa realizada na Etiópia, em 2010, a taxa de colonização foi de 20,9%. 11 Já no Irã e na Suíça, a prevalência foi de 22,8% e 21%, respectivamente.…”

Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

“…There was an increase in GBS prevalence in the state of Rio Grande do Sul, considering the results over the last 10 years [39][40][41]. A study with 36 specimens from pregnant women during the year 2006 using culture and latex agglutination for GBS identification found a prevalence of 11.11%.…”

“…A study with 36 specimens from pregnant women during the year 2006 using culture and latex agglutination for GBS identification found a prevalence of 11.11%. In addition, there was one case of meningitis caused by GBS in a newborn whose mother was colonized by GBS [41]. In 2011 and 2012, 1041 non-pregnant and 105 pregnant women were enrolled in a study where the prevalence was 15.2% among pregnant women and 6.4% in non-pregnant women [39].…”

“…Despite the lack of references to newborn infection in other studies over the last 10 years, the increase in colonization seen in these three studies and the risk for newborn infection reinforce the need for GBS screening and prophylaxis [39][40][41].…”

Infección por Streptococcus agalactiae en mujeres embarazadas entre las semanas 35 y 37 de gestación. Una revisión

“…La administración de antibióticos durante la gestación resulta ineficaz para erradicar la colonización vaginal ya que, al suprimir el tratamiento, la vagina vuelve a colonizarse a partir del recto. Se recomienda administrar al comienzo del trabajo de parto ampicilina o penicilina G iv, hasta el final del parto [21].…”