1957
DOI: 10.3181/00379727-94-22968 View full text |Buy / Rent full text
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Abstract: Previous findings have led us to postulate that the sedative and parasympathomimetic effects af reserpine are mediated through serotonin, and that serotonin may be a chemical transmitter in the parasympathetic division of the central autonomic nervous system( 1,2). These concepts are based in part on the findings that both serotonin and reserpine induce sedative effects in mice and potentiate by a central mechamism the action of certain hypnotics, the potentiation by either substance being antagonized by pretr… Show more

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“…(3) Shaking an aqueous solution of radioactive material with chloroform : octanol2 (9:1) did not remove any detectable protein or radioactivity. (4) Upon electrophoresis in 0.02 M citrate buffer, pH 4.5 for 4 hours at 500 volts, single metachromatic and radioactive spots, which exactly corresponded, were observed. (5) After digestion with microbial hepariuasc2 no radioactivity was recoverable upon the addition of carrier heparin.…”
Section: Sirmentioning
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“…(3) Shaking an aqueous solution of radioactive material with chloroform : octanol2 (9:1) did not remove any detectable protein or radioactivity. (4) Upon electrophoresis in 0.02 M citrate buffer, pH 4.5 for 4 hours at 500 volts, single metachromatic and radioactive spots, which exactly corresponded, were observed. (5) After digestion with microbial hepariuasc2 no radioactivity was recoverable upon the addition of carrier heparin.…”
Section: Sirmentioning
“…The pertinent studies showed a relationship between the characteristically delayed action of some MAO inhibitors to the gradual increase in norepinephrine levels (42). The resulting excitatory action of MAO inhibitors, such as iproniazid, was compared in Brodie's laboratory with the association of reserpine and a new category of drugs, tricyclic antidepressants, which included imipramine (43). Brodie recommended that 5HT rather than norepi nephrine may be involved in the antidepressant action of imipramine (44,45).…”
Section: Drugs Neurotransmitters and Functionmentioning
“…In recent years a number of workers have postulated that monoamine oxidase (MAO) inhibitors produce their effects by inhibiting the enzyme [7,8,9]. Some reports [8, 101 have presented evidence that M A 0 inhibitors produce their central effects by raising the brain concentration of norepinephrine while others [I 1, 121 believe that their actions are due to an increase in 5-hydroxytryptamine.…”
Section: Siddiqui [I] Isolated a New Alkaloidmentioning