“…Notably, these systems will display enhanced sensitivity to weak perturbations, maximal information flow and long spatiotemporal scales [Ruffini & Deco, 2021], and the dynamics of the system collapse to a lower dimensional (center) manifold [Jirsa & Sheheitli, 2022]. Experimental data suggests that our brains operate close to such critical boundaries [Bak et al, 1988;Chialvo, 2004;Cocchi et al, & Friston, 2019;Ruffini et al, 2022a]. During wakeful rest, the healthy brain generates data with power-law features [He, 2014], high Shannon complexity (entropy) [Abásolo et al, 2015;Hudetz et al, 2016;Moser et al, 2019], while displaying high sensitivity to external perturbations as compared to other states such as NREM sleep [Massimini et al, 2005], under propofol anesthesia or in unresponsive awareness state [Casali et al, 2013;Casarotto et al, 2016].…”