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Cited by 5 publications
(5 citation statements)
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References 7 publications
(11 reference statements)
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“…LO and LOXL-3b have been demonstrated crucial for cartilage maturation during zebrafish development, respectively (Reynaud et al, 2008;van Boxtel et al, 2011). Further, studies have indicated the upregulation of LOXL2 in OA cartilage in response to injury, which may be considered as a naturally protective response that promotes anabolism while inhibiting specific catabolic response during OA pathophysiology (Alshenibr et al, 2017;Bais and Goldring, 2017). Likewise, a recent study further confirmed that systemic adenovirus-delivered LOXL2 expression or LOXL2 genetic overexpression both exhibited chondroprotective effects through inhibition of catabolic factors and IL-1β-induced NF-κB signaling in mice (Tashkandi et al, 2019).…”
Section: Lysyl Oxidases In Cartilage Functioningmentioning
confidence: 99%
See 1 more Smart Citation
“…LO and LOXL-3b have been demonstrated crucial for cartilage maturation during zebrafish development, respectively (Reynaud et al, 2008;van Boxtel et al, 2011). Further, studies have indicated the upregulation of LOXL2 in OA cartilage in response to injury, which may be considered as a naturally protective response that promotes anabolism while inhibiting specific catabolic response during OA pathophysiology (Alshenibr et al, 2017;Bais and Goldring, 2017). Likewise, a recent study further confirmed that systemic adenovirus-delivered LOXL2 expression or LOXL2 genetic overexpression both exhibited chondroprotective effects through inhibition of catabolic factors and IL-1β-induced NF-κB signaling in mice (Tashkandi et al, 2019).…”
Section: Lysyl Oxidases In Cartilage Functioningmentioning
confidence: 99%
“…The decreased expression of LOXs may attribute to reduction of HIF-1 activity in aging organisms (Rivard et al, 2000;Ceradini et al, 2004). Meanwhile, LOXL2 has recently been demonstrated as a potential chondroprotective factor in aging related joint osteoarthritis, mainly through inducing anabolic gene expression and attenuating catabolic genes (Bais and Goldring, 2017;Tashkandi et al, 2019). Thus, restoration of collagen and elastic fiber synthesis in juvenile ECM components though regulation of signaling pathways governing LOX expression may become a promising therapeutic approach for amelioration of aging-associated cartilage degeneration and enhanced cartilage regeneration.…”
Section: Potential Links Between Lox and Aging-associated Cartilage Dmentioning
confidence: 99%
“…The in vivo expression of LOXL2 is significantly increased during the cartilage formation stage of healing fractures [ 23 , 73 ]. LOXL2 relieves osteoarthritis by promoting a chondroprotective response that includes, induction of anabolic gene expression, remodeling of the extracellular matrix and attenuation of the expression of catabolic genes [ 74 ]. LOXL2 expression is induced in the mouse model of choroidal neovascularization and its inhibition significantly reduces angiogenesis and inflammation [ 75 ].…”
Section: Discussionmentioning
confidence: 99%
“…LOXL2 is a member of the LOX gene family, which encodes a copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagens and elastin (49,50). It is involved in the progression of tumor progression and metastasis (31,49,(51)(52)(53).…”
Section: Discussionmentioning
confidence: 99%