Lowering Uric Acid in Normouricaemic Hypertensive Patients Has an Adverse Effect on Left Ventricular Hypertrophy Regression

Gingles, Christopher; Symon, Ruth; Gandy, Stephen J.; Struthers, AD; Houston, G.; MacDonald, Thomas M.; Lang, Chim C.; Donnan, Peter T.; George, Jacob

doi:10.1097/01.hjh.0000570936.23505.b7

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in another trial, allopurinol caused reduction in urate levels in normo-uricemic patients with wellcontrolled hypertension. These patients exhibited reduced left ventricular hypertrophy regression and increased oxidative stress compared to the placebo group [18]. Similar to our results, febuxostat administrated to rats with HFD-induced MS reduced fasting plasma hyperuricemia, triglycerides, insulin, blood pressure, glomerular hypertension, and afferent arteriolopathy [10].…”

Section: Discussionsupporting

confidence: 88%

Comparing the Effects of Febuxostat and Allopurinol in an Animal Model of Metabolic Syndrome

Nadwa¹,

Morcos²,

Salama³

et al. 2021

Pharmacology

View full text Add to dashboard Cite

Introduction: Recent studies highlighted the association of hyperuricemia and metabolic syndrome (MS). The aim of this study was to compare the beneficial effects of febuxostat versus allopurinol on the biochemical changes that occur in MS. Methods: Forty adult male Sprague Dawley albino rats were used in the study. Insulin resistance and MS were induced by administration of a high-fructose diet for 8 weeks. Follow-up of changes in weight, blood pressure, serum biochemical parameters, serum antioxidant catalase, and glutathione peroxidase activities was done. At the end of the study, animals were sacrificed, and the thoracic aorta was isolated for in vitro study of the endothelial integrity. Results: Allopurinol and febuxostat treatment induced significant reduction in body weight, systolic blood pressure, blood glucose, insulin, lipids, and improved kidney functions and endothelial integrity compared to nontreated rats. Febuxostat was more effective than allopurinol in normalizing serum fasting glucose, uric acid, catalase, and glutathione peroxidase activities. Conclusion: Xanthine oxidase inhibitors ameliorated the effects of MS. Febuxostat was mildly superior to allopurinol in lowering serum fasting glucose, lipids, uric acid, and antioxidant enzyme activities.

show abstract

Section: Discussionsupporting

confidence: 88%