Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death

Toole, James F.; Malinow, M.R.; Chambless, Lloyd E.; Spence, J. David; Pettigrew, L. Creed; Howard, Virginia J.; Wang, Chinhua; Stampfer, Meir J.

doi:10.1001/jama.291.5.565

JAMA

2004

DOI: 10.1001/jama.291.5.565

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Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death

James F. Toole

¹

,

M.R. Malinow²,

Lloyd E. Chambless³

et al.

Help me understand this report

Cited by 1,287 publications

(362 citation statements)

References 42 publications

Supporting

6

Mentioning

345

Contrasting

6

Unclassified

5

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“…The beneficial results observed in our study are not consistent with the results of the 2004 VISP study, HOPE 2, and NORVIT studies published in 2006 [8,22,23]. These large-scale and long-follow-up studies investigated the effect of preventive FA use on cardiovascular incidents.…”

Section: Discussioncontrasting

confidence: 99%

Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors

Kozłowska−Wojciechowska

¹

2013

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The beneficial results observed in our study are not consistent with the results of the 2004 VISP study, HOPE 2, and NORVIT studies published in 2006 [8,22,23]. These large-scale and long-follow-up studies investigated the effect of preventive FA use on cardiovascular incidents.…”

Section: Discussioncontrasting

confidence: 99%

Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors

Kozłowska−Wojciechowska

¹

2013

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our data indicate that folic acid supplementation does not affect serum lipid concentrations, which is in agreement with other studies [38–41]. …”

Section: Discussionsupporting

confidence: 94%

Effect of Homocysteine-Lowering Nutrients on Blood Lipids: Results from Four Randomised, Placebo-Controlled Studies in Healthy Humans

Olthof

¹

,

Vliet

²

,

Verhoef

³

et al. 2005

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our observation that OCM was suppressed by both atheroprotective and atherogenic shear stress patterns in EC complements prior reports demonstrating regulation of other endothelial metabolic pathways by FSS (40,41) and implies MTX is unlikely to exert a direct effect. Moreover, these findings are consistent with reports that folate supplementation does not reduce cardiovascular events in patients without systemic inflammatory disease (42)(43)(44).…”

Section: Discussionsupporting

confidence: 92%

The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism

Lang

¹

,

Leung

²

,

Greene

³

et al. 2023

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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