Lower body function as a predictor of mortality over 13 years of follow up: Findings from <scp>H</scp>ispanic <scp>E</scp>stablished <scp>P</scp>opulation for the <scp>E</scp>pidemiological <scp>S</scp>tudy of the <scp>E</scp>lderly

Nam, Sanggon; snih, Soham Al Snih al; Markides, Kyriakos S.

doi:10.1111/ggi.12650

Cited by 15 publications

(6 citation statements)

References 18 publications

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“…A strong negative correlation was seen between the SPPB and IMAT in this population (Figure 4), and also with mortality. This is consistent with the current literature [51].…”

Section: Discussionsupporting

confidence: 94%

Intramuscular Adipose Tissue and the Functional Components of Sarcopenia in Hospitalized Geriatric Patients

Perkisas

Cock²,

Verhoeven

et al. 2017

Geriatrics

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Intramuscular adipose tissue (IMAT) could be an important missing value in the assessment of sarcopenia. This study tries to determine the relation between IMAT, muscle strength, functionality and mortality. In addition, the relation with nutritional status is screened. For six months, all patients admitted to the University Geriatric Center of Antwerp were evaluated for strength (hand grip), functionality (short physical performance battery-SPPB) and nutritional status. After one year, patients/relatives were contacted to obtain a current health status (mortality). A total of 303 patients were included at a mean age of 83.0 ± 6.4 years. The mean percentage of IMAT was 29.2% ± 13.0% (range 3.2%-86.2%). There was a negative correlation between IMAT and both grip strength and SPPB. SPPB was positively correlated with both grip strength and muscle mass. There was a positive correlation between IMAT and mortality. There was a negative correlation between grip strength, SPPB and mortality. IMAT did not have a clear relation with nutritional status. IMAT should be addressed in the work-up of sarcopenia, as it is correlated with muscle strength, functionality and mortality. In this cohort of hospitalized geriatric patients, there is a mean of about one-third of measured muscle volume that appears to be adipose tissue.

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“…A strong negative correlation was seen between the SPPB and IMAT in this population (Figure 4), and also with mortality. This is consistent with the current literature [51].…”

Section: Discussionsupporting

confidence: 94%

Intramuscular Adipose Tissue and the Functional Components of Sarcopenia in Hospitalized Geriatric Patients

Perkisas

Cock²,

Verhoeven

et al. 2017

Geriatrics

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“…As expected, Perkisas et al observed that intramuscular fat was negatively correlated with both muscle strength and function. Furthermore, a significant association between intramuscular fat and mortality was found in males aged 70-79 years, but not in the whole study sample; a clear association between muscle mass, strength and function and mortality was observed in all subjects confirming and expanding previous observations, such as that observed in a cohort of hospitalized geriatric patients [5][6][7][8].…”

supporting

confidence: 87%

Myosteatosis: a relevant, yet poorly explored element of sarcopenia

2018

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“…Neither of these muscle alterations have an identical association with increased morbidity and mortality. In hospitalized geriatric patients, myosteatosis is associated with high mortality only in male patients, while sarcopenia was a risk factor for overall death among the whole geriatric cohort [17][18][19][20].…”

Section: Introductionmentioning

confidence: 97%

Skeletal muscle atrophy and myosteatosis are not related to long-term aneurysmal subarachnoid hemorrhage outcome

et al. 2022

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The prognosis of aneurysmal subarachnoid hemorrhage (aSAH) is highly variable. This study aims to investigate whether skeletal muscle atrophy and myosteatosis are associated with poor outcome after aSAH. In this study, a cohort of 293 consecutive aSAH-patients admitted during a 4-year period was retrospectively analyzed. Cross-sectional muscle measurements were obtained at the level of the third cervical vertebra. Muscle atrophy was defined by a sex-specific cutoff value. Myosteatosis was defined by a BMI-specific cutoff value. Poor neurological outcome was defined as modified Rankin Scale 4–6 at 2 and 6-month follow-up. Patient survival state was checked until January 2021. Generalized estimating equation was performed to assess the effect of muscle atrophy / myosteatosis on poor neurological outcome after aSAH. Cox regression was performed to analyze the impact of muscle atrophy and myosteatosis on overall survival. The study found that myosteatosis was associated with poor neurological condition (WFNS 4–5) at admission after adjusting for covariates (odds ratio [OR] 2.01; 95%CI 1.05,3.83; P = .03). It was not associated with overall survival (P = .89) or with poor neurological outcomes (P = .18) when adjusted for other prognostic markers. Muscle atrophy was not associated with overall survival (P = .58) or neurological outcome (P = .32) after aSAH. In conclusion, myosteatosis was found to be associated with poor physical condition directly after onset of aSAH. Skeletal muscle atrophy and myosteatosis were however irrelevant to outcome in the Western-European aSAH patient. Future studies are needed to validate these finding.

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Lower body function as a predictor of mortality over 13 years of follow up: Findings from Hispanic Established Population for the Epidemiological Study of the Elderly

Cited by 15 publications

References 18 publications

Intramuscular Adipose Tissue and the Functional Components of Sarcopenia in Hospitalized Geriatric Patients

Intramuscular Adipose Tissue and the Functional Components of Sarcopenia in Hospitalized Geriatric Patients

Myosteatosis: a relevant, yet poorly explored element of sarcopenia

Skeletal muscle atrophy and myosteatosis are not related to long-term aneurysmal subarachnoid hemorrhage outcome

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