Lower anti-Müllerian hormone levels are associated with HIV in reproductive age women and shorter leukocyte telomere length among late reproductive age women

Ommen, Clara E. Van; Hsieh, Anthony Y Y; Albert, Arianne; Kimmel, Elana R; Côté, Hélène; Maan, Evelyn J.; Prior, Jerilynn C.; Pick, Neora; Murray, Melanie

doi:10.1097/qad.0000000000003481

Cited by 5 publications

(1 citation statement)

References 45 publications

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“…However, three studies did assess whether women living with HIV were more likely to have very low AMH (i.e., below a certain cut-point) compared with HIV-negative women. Consensus on the exact cut-point that constitutes low AMH is lacking; indeed, different cut-points ranging from less than 7.1 to 14.3 pmol/L have been used to define low AMH [28,29]. Merlini et al [15] found that women living with HIV had greater odds of low AMH (<7.1 pmol/L) than did HIV-negative women after adjusting for age and smoking status (adjusted odds ratio 3.9 [95% CI 1.73-8.90]; p = 0.01).…”

Section: Author Yearmentioning

confidence: 99%

Markers of ovarian reserve in women living with HIV: A systematic review

2022

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Background Anti‐Mullerian hormone (AMH) levels indicate ovarian reserve and are predictive of reproductive aging. Studies evaluating AMH levels in women with HIV have produced conflicting results, and reasons for inter‐study differences have not been assessed. To understand reproductive aging in HIV, we conducted a systematic review of ovarian reserve among women with HIV. Methods We searched Ovid MEDLINE, Ovid EMBASE, and CAB Direct for studies including AMH in reproductive‐aged women with HIV. Two reviewers used the Newcastle–Ottawa scale to assess the quality of extracted data. Results Of the 315 reports screened, ten met the inclusion criteria. Studies were conducted across seven countries and included 3673 women with HIV and 2342 HIV‐negative women in the comparison group. Ethnic distribution, combination antiretroviral therapy coverage, and viral load suppression varied considerably across studies. Nine of the ten reviewed studies reported lower unadjusted AMH levels in women with HIV than in those without HIV; however, in studies that adjusted for confounders (n = 4), only two showed an association between HIV and AMH. Low CD4 count and high viral load correlated with low AMH in the two largest studies. Other studies found that opioid use and elevated inflammatory markers were associated with low AMH. Study quality varied considerably, and many were of low quality (n = 6). Conclusion Current evidence is inconclusive about the relationship between HIV and AMH, although studies suggest a trend toward lower AMH among women with HIV. Future studies that adjust for HIV‐related factors, inflammatory markers, and substance use are needed in the era of contemporary HIV care to confirm the association between HIV and reduced ovarian reserve and establish its underlying cause.

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Section: Author Yearmentioning

confidence: 99%

Markers of ovarian reserve in women living with HIV: A systematic review

2022

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Associations of Early Prolonged Secondary Amenorrhea in Women With and Without HIV

Swann,

King,

Pang

et al. 2024

Open Forum Infectious Diseases

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Background The menstrual cycle is a critical indicator of women’s health. Early prolonged secondary amenorrhea increases risks for morbidity and mortality. Menstrual cycle research in women with HIV is inconsistent and often lacks an adequate comparison sample. We aimed to determine whether women with HIV have a higher lifetime prevalence of amenorrhea and whether this is independently associated with HIV and/or other bio-psycho-social variables. Methods Using data from two established HIV cohorts, participants assigned female at birth were eligible if aged ≥16 years, not pregnant/lactating, and without anorexia/bulimia nervosa history. Amenorrhea was defined by self-reported history of 1) no menstrual flow for ≥12 months post-menarche, not due to pregnancy/lactation, medications, or surgery, or 2) early menopause or premature ovarian insufficiency. Multivariable logistic regression models explored bio-psycho-social covariates of amenorrhea. Results Overall, 317 women with HIV (median [IQR] age: 47.5 [39.2 to 56.4] years) and 420 women without HIV (age: 46.2 [32.6 to 57.2]) were included. Lifetime amenorrhea was significantly more prevalent among women with HIV than women without HIV (24.0 versus 13.3%). In the multivariable analysis, independent covariates of amenorrhea included living with HIV (adjusted odds ratio=1.70 [1.10-2.64]), older age (1.01 [1.00-1.04]), white ethnicity (1.92 [1.24-3.03]), substance use history (6.41 [3.75-11.1]), and current food insecurity (2.03 [1.13-3.61]). Conclusions Nearly one-quarter of women with HIV have experienced amenorrhea and this is associated with modifiable risk factors including substance use and food insecurity. Care providers should regularly assess women’s menstrual health and advocate for actionable socio-structural change to mitigate risks.

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The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review

Macamo,

Mkhize-Kwitshana,

Mthombeni

et al. 2024

CIMB

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HIV and parasite infections accelerate biological aging, resulting in immune senescence, apoptosis and cellular damage. Telomere length is considered to be one of the most effective biomarkers of biological aging. HIV and parasite infection have been reported to shorten telomere length in the host. This systematic review aimed to highlight work that explored the influence of HIV and parasite single infections and coinfection on telomere length. Using specific keywords related to the topic of interest, an electronic search of several online databases (Google Scholar, Web of Science, Scopus, Science Direct and PubMed) was conducted to extract eligible articles. The association between HIV infection or parasite infection and telomere length and the association between HIV and parasite coinfection and telomere length were assessed independently. The studies reported were mostly conducted in the European countries. Of the 42 eligible research articles reviewed, HIV and parasite single infections were independently associated with telomere length shortening. Some studies found no association between antiretroviral therapy (ART) and telomere length shortening, while others found an association between ART and telomere length shortening. No studies reported on the association between HIV and parasite coinfection and telomere length. HIV and parasite infections independently accelerate telomere length shortening and biological aging. It is possible that coinfection with HIV and parasites may further accelerate telomere length shortening; however, this is a neglected field of research with no reported studies to date.

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Lower anti-Müllerian hormone levels are associated with HIV in reproductive age women and shorter leukocyte telomere length among late reproductive age women

Cited by 5 publications

References 45 publications

Markers of ovarian reserve in women living with HIV: A systematic review

Markers of ovarian reserve in women living with HIV: A systematic review

Associations of Early Prolonged Secondary Amenorrhea in Women With and Without HIV

The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review

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