Low Vitamin D levels predict clinical features of schizophrenia

Cieslak, Kristina; Feingold, Jordyn; Antonius, Daniel; Walsh‐Messinger, Julie; Dracxler, Roberta; Rosedale, Mary; Aujero, Nicole; Keefe, David L.; Goetz, Deborah; Goetz, Raymond R.; Malaspina, Dolores

doi:10.1016/j.schres.2014.08.031

Cited by 56 publications

(55 citation statements)

References 25 publications

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“…Indeed, inadequate neurosteroid action of vitamin D on the brain, particularly during development, is related to the changes such as inflammatory and immunological disturbances, which are present in schizophrenia, too (49,50). Therefore, the cases of very low serum levels of 25(OH)D in our study probably point to patients with serious mental disorders that required the prescription of clozapine, the first line option for treatment-resistant psychotic features.…”

Section: Discussionmentioning

confidence: 72%

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Ristic

Živanović

Milovanovic

et al. 2017

J Nutr Sci Vitaminol

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SummaryThis research aimed to investigate factors associated with vitamin D deficiency and to provide data about its prevalence in patients suffering from different psychiatric illnesses. The study had a cross-sectional design and it included 220 patients of both genders, aged from 19-81 y, with a wide range of mental disorders (F00-F89), and treated in routine ambulatory and hospital practice. The researchers collected data from three sources: medical records, a study questionnaire and biochemical analysis of patients' serum samples (concentration of vitamin D measured as 25(OH)D, calcium, phosphorus, magnesium, sodium and potassium). Data were analyzed using descriptive statistics, methods for hypothesis testing and binary logistic regression, at the p#0.05 level. A total of 140 patients (64%) had a deficiency of vitamin D (,12 ng/mL), and 45 (20%) had inadequate vitamin D serum levels (12-20 ng/mL), while 35 (16%) had sufficient vitamin D serum concentrations (.20 ng/mL). Among variables related to demographics, life style habits, mental illness, comorbid disorders and drugs, two of them, female gender (odds ratio (OR)52.5, 95% confidence interval (CI)51.3-4.9, p50.006) and using clozapine (OR515.6, 95% CI 1.7-144.7, p50.02), were significantly associated with vitamin D deficiency. Physical activity (OR5 0.4, p50.02), exercising (OR50.2, 95% CI , p50.02) and offal in the diet (OR50.5, 95% CI 0.3-0.9, p50.03) significantly aggregated in the patients who had a 25(OH)D serum concentration above the deficiency cut-off level. Patients with mental disorders are at high risk for vitamin D deficiency, particularly females and clozapine users as well as those having no adequate physical activity or dietary habits.

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Section: Discussionmentioning

confidence: 72%

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Ristic

Živanović

Milovanovic

et al. 2017

J Nutr Sci Vitaminol

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“…Consistent with this finding, Groves et al (33) reported decreased levels of Glu and Gln in vitamin D‐deficient BALB/c mice. Dysfunction of the glutamate system in the prefrontal cortex is associated with schizophrenia, and that 1,25D apparently modulates Glu neurotransmission is suggestive of possible neuropsychiatric benefits of vitamin D centered on supporting GABA neurotransmission (34, 35).…”

Section: Discussionmentioning

confidence: 99%

1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D

Kaneko¹,

Sabir²,

Dussik³

et al. 2015

The FASEB Journal

149

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To investigate vitamin D-related control of brain-expressed genes, candidate vitamin D responsive elements (VDREs) at 27/210 kb in human tryptophan hydroxylase (TPH)2 were probed. Both VDREs bound the vitamin D receptor (VDR)-retinoid X receptor (RXR) complex and drove reporter gene transcription in response to 1,25-dihydroxyvitamin D 3 (1,25D). Brain TPH2 mRNA, encoding the rate-limiting enzyme in serotonin synthesis, was induced 2.2-fold by 10 nM 1,25D in human U87 glioblastoma cells and 47.8-fold in rat serotonergic RN46A-B14 cells. 1,25D regulation of leptin (Lep), encoding a serotoninlike satiety factor, was also examined. In mouse adipocytes, 1,25D repressed leptin mRNA levels by at least 84%, whereas 1,25D induced leptin mRNA 15.1-fold in human glioblastoma cells. Chromatin immunoprecipitation sequencing analysis of the mouse Lep gene in response to 1,25D revealed a cluster of regulatory sites (cis-regulatory module; CRM) at 228 kb that 1,25D-dependently docked VDR, RXR, C/EBPb, and RUNX2. This CRM harbored 3 VDREs and single C/EBPb and RUNX2 sites. Therefore, the expression of human TPH2 and mouse Lep are governed by 1,25D, potentially via respective VDREs located at 27/210 kb and 228 kb. These results imply that vitamin D affects brain serotonin concentrations, which may be relevant to psychiatric disorders, such as autism, and may control leptin levels and affect eating behavior.-Kaneko, I., Sabir, M. S., Dussik, C. M., Whitfield, G. K., Karrys, A., Hseih, J.-C., Haussler, M. R., Meyer, M. B., Pike, J. W., Jurutka, P. W. 1,25-dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB J. 29, 4023-4035 (2015 (1,25D), acts as a classic nuclear receptor ligand that binds specifically to the vitamin D receptor (VDR) to control the transcription of a multitude of genes, primarily those encoding proteins participating in bone mineral metabolism, regulating the immune system, and controlling cell growth and differentiation (1). Liganded VDR attracts one of the retinoid X receptors (RXRs) into a heterodimer that recognizes vitamin D responsive elements (VDREs) in the vicinity of target genes, regulating their expression via the recruitment of comodulator complexes that modify chromatin to effect either induction or repression of the cognate mRNA (2-4). A currently understudied area of vitamin D's function and significance is the CNS, even though the VDR protein is reportedly expressed broadly in the brain, including the neurons and glial cells (5). The most intense immunochemical signal is present in the hypothalamus (paraventricular and supraoptic nuclei and the lateral and ventromedial regions) and in the dopaminergic neurons of the substantia nigra (6). However, VDR protein is also detected in prefrontal cortex, cingulate gyrus, and CA2 region of the hippocampus. Thus, the VDR protein is clearly present in the CNS, but only limited information is available on the functions of VDR and its 1,25D ligand in the bra...

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“…17 Tengsl milli lágs styrks D-vítamíns í blóði og geðrofssjúkdóma hafa sést í rannsóknum og einhver teikn eru á lofti um að einkenni sjúkdómsins gaetu verið verri við lágan styrk. 18,19 Ein af þeim tilgát-um sem settar hafa verið fram til að útskýra þessar niðurstöður er að D-vítamín gegni mikilvaegu hlutverki við myndun á taugaboð-efninu serótónín, sem meðal annars tekur þátt í ferlum tengdum félagsfaerni og vitsmunagetu. 20 Einkenni geðrofssjúkdóma geta meðal annars falið í sér skerta vitsmunagetu og tilhneigingu til að draga sig í hlé félagslega.…”

Section: Umraeðaunclassified

Fæðuval ungra Íslendinga með geðrofssjúkdóma og þróun líkamsþyngdar þeirra á 8 til 12 mánaða tímabili

Fridthjofsdottir¹,

Geirsdóttir²,

Jónsdóttir³

et al. 2017

LBL

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Low Vitamin D levels predict clinical features of schizophrenia

Cited by 56 publications

References 25 publications

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

Vitamin D Deficiency and Associated Factors in Patients with Mental Disorders Treated in Routine Practice

1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D

Fæðuval ungra Íslendinga með geðrofssjúkdóma og þróun líkamsþyngdar þeirra á 8 til 12 mánaða tímabili

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