Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis

Shin, Dong Yeob; Kim, Kwang Joon; Kim, Daham; Hwang, Seong‐Ju; Lee, Mi Kyung

doi:10.3349/ymj.2014.55.2.476

Cited by 98 publications

(97 citation statements)

References 28 publications

(33 reference statements)

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“…Distinct from these studies we excluded the subclinical hypothyroidism patients whose ages were not higher than 70 years. In another study, Shin et al (2014) demonstrated a negative association between 25-OH D and anti-TPO levels, and also indicated that the low 25-OH D level was a possible risk factor of anti-TPO positivity.…”

Section: Discussionmentioning

confidence: 88%

Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Uçar¹,

Akyol²,

Öztürk³

et al. 2014

jecm

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Article HistoryReceived 12 / 05 / 2014 Accepted 07 / 06 / 2014Increasing numbers of researches have indicated the relationship between serum vitamin D level and several autoimmune diseases, because it has important roles in immune regulation. However, the role of vitamin D in the etiopathogenesis of these diseases is not well understood. Similarly, the detailed mechanism of vitamin D action on thyroid hormone metabolism and autoimmune thyroid diseases is still poorly understood. It was recently reported that patients with autoimmune thyroid disease showed lower vitamin D levels. However, there are few studies dealing with vitamin D status in elderly patients with subclinical hypothyroidism. We therefore aimed to investigate vitamin D levels in elderly patients with subclinical hypothyroidism. In the present study, a total of 37 patients (>70 years old) with subclinical hypothyroidism and 40 healthy controls (>70 years old) were retrospectively analyzed. Serum levels of free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) were analyzed by chemiluminescence immunoassay (Centaur XP, Siemens Healthcare Diagnostics Inc., Tarrytown, USA). Serum levels of 25-Hydroxy vitamin D (25-OH D) were measured by chemiluminescence immunoassay (DiaSorin, Liaison, Italy). Serum anti thyroid peroxidase (anti-TPO) and anti thyroglobulin (anti-TG) were measured using a solid-phase, enzyme-labeled, chemiluminenescent sequential immunometric assay (Immulite 2000 XPi, Siemens Healthcare Diagnostics Inc., Tarrytown, USA). There was no significant difference between groups in terms of age and gender distribution. Serum TSH, anti-TPO and anti-TG levels in elderly patients with subclinical hypothyroidism showed higher values than healthy controls as expected. Serum 25-OH D levels in elderly patients with subclinical hypothyroidism were lower than healthy controls (p<0.001). These data may suggest association between serum 25-OH D levels and subclinical hypothyroidism in elderly patients. Further studies are needed to determine whether vitamin D insufficiency is a casual factor in the etiopathogenesis of subclinical hypothyroidism in elderly patients or rather a consequence of the disease.

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Section: Discussionmentioning

confidence: 88%

Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Uçar¹,

Akyol²,

Öztürk³

et al. 2014

jecm

View full text Add to dashboard Cite

show abstract

“…9 In human studies on the association of vitamin D levels with antithyroid antibodies, lower 25(OH)D levels were found in subjects with higher levels of antithyroid antibodies compared with those who were negative for thyroid autoimmunity. 10 Vitamin D deficiency has been diagnosed more frequently in AITD subjects, especially in those affected by Hashimoto's thyroiditis, than in healthy subjects. 11 In female patients with newly onset GD, a significant relationship of low levels of 25(OH)D with increased thyroid volume was observed, suggesting that vitamin D status may be involved in the pathogenesis of the disease.…”

Section: Vitamin D and Thyroid Autoimmune Diseasementioning

confidence: 99%

The Concept of Vitamin D Sufficiency and Insufficiency in Graves Disease

Latif

2017

Birdem Med J

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“…The role of vitamin D as an immune modulator has been recently emphasized [20]. A recent study conducted in Korea found that patients with elevated antithyroid antibodies had lower levels of serum 25(OH)D3 than those without such elevations [21]. A study conducted in 2011 showed that the prevalence of vitamin D deficiency was significantly higher in patients with autoimmune thyroid diseases than in healthy individuals (72% vs.…”

Section: Associated Disease Frequency Percentagementioning

confidence: 99%

Clinical Presentation of Acquired Hypothyroidism and Associated Disorders in Children and Adolescents at King Abdul-Aziz University Hospital in a Western Region of Saudi Arabia

Ae¹,

Rm²,

Wa³

et al. 2017

J Pat Care

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Objective: We aimed to investigate the clinical manifestations and associations of acquired hypothyroidism in children at King Abdul-Aziz University Hospital (KAUH) in the western region of Saudi Arabia.Methods: A retrospective descriptive study was conducted in Jeddah, Saudi Arabia from January 2010 to January 2015. The study included 265 children aged between one and 18 years old with a confirmed diagnosis of acquired hypothyroidism who attended the pediatric endocrine clinic at KAUH. Data were obtained by reviewing the medical records and laboratory investigations of the patients by using KAUH's "phoenix" system. Results:Of the 265 children diagnosed with acquired hypothyroidism, the commonest clinical presentations were short stature (32.5%), loss of appetite (16.2%), weight gain (13.6%), fatigability (12.1%), constipation (9.8%), cold intolerance (5.3%), and goiter (2.6%). Vitamin D deficiency was the commonest associated disorder (present in 37% of patients) followed by type 1 diabetes mellitus (in 22.3%) and Down syndrome (in 8.3%). Conclusion:Isolated short stature was the most common presentation of acquired hypothyroidism. Pediatricians should be aware of the need to screen children who present with short stature for hypothyroidism. Vitamin D deficiency was the commonest disorder associated with acquired hypothyroidism. In our setting, vitamin D supplementation would be beneficial as a preventive measure. thyroid hormone will help to restore normal sexual development and high velocity. The aim of present study was to investigate the clinical manifestations and associations of acquired hypothyroidism in children and adolescents at King Abdul-Aziz University Hospital (KAUH) in the western region of Saudi Arabia. Methods Study setting and participantsA retrospective descriptive study was conducted to review the clinical presentation and associated disorders of acquired hypothyroidism. Data collection took place at King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia. The population was 265 children and adolescents aged one to 18 years at the time of diagnosis.The data was obtained by reviewing the medical records of children and adolescents with acquired hypothyroidism that was being followed up at the pediatric endocrinology clinic at KAUH from January 2010 to Citation: Al-Agha AE, Alshugair RM, Aljunedi WA, Badakhan BA (2016) Clinical Presentation of Acquired Hypothyroidism and Journal of Patient Care

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Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis

Cited by 98 publications

References 28 publications

Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

The Concept of Vitamin D Sufficiency and Insufficiency in Graves Disease

Clinical Presentation of Acquired Hypothyroidism and Associated Disorders in Children and Adolescents at King Abdul-Aziz University Hospital in a Western Region of Saudi Arabia

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Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis

Cited by 98 publications

References 28 publications

Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

The Concept of Vitamin D Sufficiency and Insufficiency in Graves Disease

Clinical Presentation of Acquired Hypothyroidism and Associated Disorders in Children and Adolescents at King Abdul-Aziz University Hospital in a Western Region of Saudi Arabia

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The Concept of Vitamin D Sufficiency and Insufficiency in Graves Disease