Low Serum Mannose-Binding Lectin as a Risk Factor for New Onset Diabetes Mellitus After Renal Transplantation

Abstract

Low pretransplant MBL is associated with chronic inflammation, NODAT, and infection.

Hyperviscosity in Renal Transplant Recipients

“…The association between inflammation and CVD is especially evident in patients with renal disease. Despite the fact that classic markers of chronic inflammation decrease after transplantation [32], systemic inflammation remains increased in stable grafts months after transplantation [33], and pretransplantation inflammation has been associated with longterm graft outcomes in renal transplants [34]. Consistent with these data, we found higher LDL and CRP values in renal transplant patients with high viscosity.…”

Low serum mannose-binding lectin levels are associated with inflammation and apoptosis in early surveillance allograft biopsies

“…A cohort of consecutive renal transplants performed at Hospital Universitari de Bellvitge between 2005 and 2006 were recruited to evaluate the relationship among serum MBL levels, infections, NODAT and chronic inflammation as previously described [11]. For the present study, we considered those patients in whom a surveillance 3-6 months allograft biopsy was performed.…”

“…The first tertile was considered as the low MBL group and the two higher tertiles were considered as the high MBL group as previously described [11].…”

Functional Mannose-Binding Lectin Levels in Patients with End-Stage Renal Disease on Maintenance Hemodialysis

“…more severe renal disease in cases of IgA nephropathy (Roos et al [19]) and in patients with antinuclear antibody-negative Pauci-immune crescentic glomerulonephritis (Xing et al [20]). In dialysis patients (Ibernon et al [21]), low pretransplant levels of MBL were associated with chronic inflammation, new-onset diabetes mellitus after transplantation, and infection. Nevertheless, there are only a few reports on the role of MBL in CRF patients.…”