Low serum ferritin slowed 54Mn gastrointestinal transit time in women fed low manganese diet

Momčilović, Berislav; Lykken, Glenn I.; Ivičić, Nikola; Prejac, Juraj

doi:10.5414/tep26131

Cited by 5 publications

(4 citation statements)

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“…The higher Mn concentrations in sportsmen would be linked to an increased organic utilization of this mineral in the mitochondrial Mn-SOD production processes, among others [ 34 ]. Higher basal blood Mn concentrations in aerobic athletes in comparison with other metabolic sportsmen could be linked to a probably lower iron (Fe) levels, fact that is common in long distance sportsmen, as a consequence of the impact of Fe body levels in Mn metabolism [ 35 , 36 ]. In this sense, it has been observed increased blood Mn levels in Fe deficitary cases [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Seric concentrations of copper, chromium, manganesum, nickel and selenium in aerobic, anaerobic and mixed professional sportsmen

Maynar

Llerena

Bartolomé

et al. 2018

Journal of the International Society of Sports Nutrition

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BackgroundThe aim of the present study was to determine changes in serum concentrations of trace elements Cooper (Cu), Chromiun (Cr), Manganesum (Mn), Nickel (Ni) and Selenium (Se) in high-level sportsmen.MethodsEighty professional athletes of different metabolic modalities, were recruited before the start of their training period. Thirty one sedentary participants of the same geographic area constituted the control group. Cu, Cr, Mn, Ni and Se analysis was performed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS).ResultsHigher concentrations of Cr (p < 0.001), Mn (p < 0.085), and Ni (p < 0.001) were found in sportsmen in comparison to controls, inversely, Se values were lower (p < 0.001) among sportsmen. When sportsmen were classified by metabolic modalities, it was found that aerobic-anaerobic group had higher (p < 0.01) Cu concentrations than controls and the other sportsmen. The highest Cr values were found in aerobic participants. For Mn, the major levels were found in aerobic and aerobic-anaerobic groups as well (p < 0.001). The lowest Se levels were found among anaerobic sportsmen (p < 0.001).ConclusionThis research showed that daily, continuum physical training induced alterations in serum essential minerals concentrations, as well as that these changes can be dependent of the exercise modality practiced.

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Section: Discussionmentioning

confidence: 99%

Seric concentrations of copper, chromium, manganesum, nickel and selenium in aerobic, anaerobic and mixed professional sportsmen

Maynar

Llerena

Bartolomé

et al. 2018

Journal of the International Society of Sports Nutrition

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“…For example, if the body is subjected to Fe deficiency, the absorption of metabolically alike Mn is increased. 148 On a molecular level, various mechanisms might be responsible for the relationship and equilibrium of certain metals. For example, Zn deficiency has been reported to up-regulate the intestinal Zn-transporter (ZIP4).…”

Section: Part III -Modelling Biometal Profiles In Neurological Diseasesmentioning

confidence: 99%

Characterization of biometal profiles in neurological disorders

Pfaender

Grabrucker

2014

Metallomics

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Many neurodegenerative and neuropsychiatric disorders have been reported to coincide with the dysregulation of metal ions in the body and central nervous system. However, in most cases, it is not the imbalance of a single divalent metal ion but a plethora of metal ions reported to be altered. Given that different divalent metal ions are often able to bind to a protein in a competitive manner, although with different affinities, and that they might use similar transporters for uptake and regulation, it is likely that the imbalance of one metal ion will downstream affect the homeostasis of other metal ions. Thus, based on this assumption, we hypothesize that the dysregulation of a specific metal ion will lead to a characteristic biometal profile. Similar profiles might therefore be detected in various neurological disorders. Moreover, if such shared biometal profiles exist across different neurological disorders, it is possible that shared behavioural impairments in these disorders result from the imbalance in metal ion homeostasis. Thus, here, we evaluate the reported excess or deficiency of metal ions in various neurological disorders and aim to integrate reported alterations in metal ions to generate a characteristic biometal profile for the disorder. Based on this, we try to predict which alterations in biometals will be caused by the overload or deficiency of one particular metal ion. Moreover, investigating the behavioural phenotypes of rodent models suffering from alterations in biometals, we assess whether a shared behavioural phenotype exists for disorders with similar biometal profiles. Our results show that observed behavioural aspects of some neurological disorders are reflected in their specific biometal profile and mirrored by mouse models suffering from similar biometal deregulations.

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“…Conversely, a higher iron status (i.e. higher ferritin concentrations) has been shown to be associated with significantly lower manganese absorption (Finley, 1999) and retention (Momcilovic et al, 2009). In addition, absorption of manganese has been observed to be lower in men than in women (18-40 years), which may be related to the fact that men usually have higher iron stores than women (Finley et al, 1994).…”

Section: Interaction With Ironmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for manganese

Products¹

2013

EFS2

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for manganese. Manganese is an essential dietary mineral which is a component of a number of metalloenzymes involved in amino acid, lipid and carbohydrate metabolism. A specific manganese deficiency syndrome has not been described in humans. The body is able to adapt to a wide range of manganese intakes by regulating both efficiency of absorption in the intestine and the quantity excreted via bile. There are no reliable and validated biomarkers of manganese intake or status and data on manganese intakes versus health outcomes are not available for DRVs for manganese. As there is insufficient evidence available to derive an average requirement or a population reference intake, an Adequate Intake (AI) is proposed. Mean intakes of manganese in adults in the EU are around 3 mg/day. In addition, null or positive balances have consistently been observed with intakes of manganese above 2.5 mg/day. An AI of 3 mg/day is proposed for adults, including pregnant and lactating women. For infants aged from 7 to 11 months, an AI of 0.02-0.5 mg/day is proposed, which reflects the wide range of manganese intakes that appear to be adequate for this age group. The AI for children and adolescents is based on extrapolation from the adult AI using isometric scaling and reference body weights of the respective age groups. Manganese is an essential dietary element for mammals. It is a component of metalloenzymes such as superoxide dismutase, arginase and pyruvate carboxylase, and is involved in amino acid, lipid and carbohydrate metabolism. A specific manganese deficiency syndrome has not been described in humans.Absorption of manganese in the intestine is low (< 10 %). Regulation at the level of absorption appears to be one of the adaptive responses to dietary manganese intake and such regulation allows manganese homeostasis to be maintained over a wide range of intakes. A reduction in the biological half-life of manganese has been observed with increased dietary manganese intakes indicating the role of whole-body turnover rate in manganese homeostasis. Elimination of manganese is primarily via the faeces.The assessment of manganese intake or status using biological markers is difficult owing to the rapid excretion of manganese into bile, to homeostatic mechanisms and to the lack of sensitivity of biomarkers over the normal range of intakes. Therefore, there are no reliable and validated biomarkers of manganese intake or status.Nuts, chocolate, cereal-based products, crustaceans and molluscs, pulses, and fruits and fruit products are rich sources of manganese. The main contributors to the manganese intake of adults are cerealbased products, vegetables, fruits and fruit products and beverages. In the EU, estimated mean manganese intakes of adults range from 2 to 6 mg/day, with a majority of values around 3 mg/day. Estimated mean manganese intakes range from 1.5 to 3.5 mg/day in ...

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Low serum ferritin slowed 54Mn gastrointestinal transit time in women fed low manganese diet

Cited by 5 publications

References 0 publications

Seric concentrations of copper, chromium, manganesum, nickel and selenium in aerobic, anaerobic and mixed professional sportsmen

Seric concentrations of copper, chromium, manganesum, nickel and selenium in aerobic, anaerobic and mixed professional sportsmen

Characterization of biometal profiles in neurological disorders

Scientific Opinion on Dietary Reference Values for manganese

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