Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission

Visser, Marjolein; Deeg, D.J.H.; Puts, Martine; Seidell, J.C.; Lips, Paul

doi:10.1093/ajcn/84.3.616

Cited by 198 publications

(95 citation statements)

References 54 publications

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“…Higher levels than this do not appear to offer any additional beneficial effect regarding the risk of falling. 81 Thus, most of the current literature data concur that vitamin D deficiency leads to myopathy, reduced muscle mass and strength, low exercise performance and an increased risk of falling, 83 while higher vitamin D levels have been associated with improved balance, reduced frailty and disability, 84,85 maintenance of functional independence 86 and better mobility. 53,87,88 other major trials have also confirmed that vitamin D supplementation lowers the risk of falling and fractures in the elderly.…”

Section: Association Between Low Vitamin D Levels and The Risk Of Falmentioning

confidence: 98%

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Koundourakis¹,

Avgoustinaki²,

Malliaraki³

et al. 2017

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Section: Association Between Low Vitamin D Levels and The Risk Of Falmentioning

confidence: 98%

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Koundourakis¹,

Avgoustinaki²,

Malliaraki³

et al. 2017

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“…This analysis has stimulated other researchers of cohort studies to include allcause mortality as an outcome, along with CVD (Table 3). Surprisingly, the first cohort study to report on the association between baseline 25(OH)D levels and subsequent risk of death, which was from the Netherlands, was missed in the subsequent rush of papers on this topic, perhaps because its focus was on predicting admission to nursing homes rather than death (126) . However, since then, eleven other cohort studies have reported on this association (Table 3) (97,(99)(100)(101)(102)(103)105,106,(127)(128)(129) .…”

Section: All-cause Mortalitymentioning

confidence: 99%

Vitamin D and public health: an overview of recent research on common diseases and mortality in adulthood

Scragg

2011

Public Health Nutr.

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Objective: There is increasing interest in vitamin D and its possible health effects. The aims of the present overview are to summarise the research on common diseases for which there is substantial evidence on vitamin D, identify diseases where vitamin D may be beneficial and discuss the public health implications of these findings. Conclusions: Cohort studies show that baseline 25(OH)D levels predict increased risk of fractures, colorectal cancer, CVD and all-cause mortality. These associations are weak and could be explained by confounding variables such as obesity and physical activity. Because of their potential public health significance, RCT using vitamin D doses $50 mg/d are required to determine whether vitamin D protects against these diseases.

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“…Several population-based studies have reported vitamin D status in age groups from children to centenarians, as well as in isolated groups of individuals with discrete diseases (11)(12)(13)(14)(15). Individuals who would otherwise be considered healthy typically have serum 25(OH)D levels averaging in the range of 50 to 65 nmol/L, and from 65 to 100% of such populations have levels Ͻ80 nmol/L.…”

Section: Prevailing Vitamin D Statusmentioning

confidence: 99%

Vitamin D in Health and Disease

Heaney

2008

Clinical Journal of the American Society of Nephrology

389

348

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Vitamin D functions in the body through both an endocrine mechanism (regulation of calcium absorption) and an autocrine mechanism (facilitation of gene expression). The former acts through circulating calcitriol, whereas the latter, which accounts for more than 80% of the metabolic utilization of the vitamin each day, produces, uses, and degrades calcitriol exclusively intracellularly. In patients with end-stage kidney disease, the endocrine mechanism is effectively disabled; however, the autocrine mechanism is able to function normally so long as the patient has adequate serum levels of 25(OH)D, on which its function is absolutely dependent. Calcitriol functioned as a hormone, circulating in the blood to stimulate the induction of various components of the calcium transport system in the intestinal mucosa. The net result was that active calcium absorption was increased and the efficiency of calcium absorption, normally low, was augmented so as to enable controlled adaptation to varying calcium intakes.This scheme remains correct, so far as it goes, but it is now understood that many tissues, particularly components of the immune apparatus and various epithelia, are able to express 1-␣-hydroxylase and to synthesize calcitriol locally, as depicted in Figure 1B. The upper right-hand branch represents the endocrine pathway, and the lower branch represents the autocrine pathway. There are three key features of the revised scheme: (1) The bulk of the daily metabolic utilization of vitamin D is by way of the peripheral, autocrine pathway; (2) among other effects, the autocrine action always results in expression of the 24-hydroxylase; as a result, locally synthesized calcitriol is degraded immediately after it acts, and, thus, no calcitriol enters the circulation; and (3) local concentrations of calcitriol required to support various tissue responses are higher than typical serum concentrations of calcitriol.In the cells and tissues that are the locus of the autocrine pathway, the synthesized calcitriol serves as a key link in the signaling apparatus that connects extracellular stimuli to genomic response. It has become clear in recent years that many tissues possess the proteins, enzymes, and signaling molecules that they need only in virtual form (i.e., encoded in the DNA blueprints in the nucleus). When the cells of such tissues are exposed to an extracellular stimulus or signal that calls for them to mount a response that requires some of these proteins or catalysts, they do so by opening up their library of DNA blueprints, finding the ones that are appropriate for the situation, and then synthesizing those proteins by transcribing the information that is encoded in the DNA. Figure 2 illustrates this process, showing specifically the key role played by intracellularly synthesized calcitriol.When bound to the vitamin D receptor and a variety of other helper proteins, calcitriol seems to be just the right key to open up the locked stores of DNA information, allowing the cell to transcribe the plans and produce the p...

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Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission

Abstract: Lower serum 25(OH)D concentrations in older persons are associated with a greater risk of future nursing home admission and may be associated with mortality.

Cited by 198 publications

References 54 publications

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Vitamin D and public health: an overview of recent research on common diseases and mortality in adulthood

Vitamin D in Health and Disease

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