Low serum 25-hydroxyvitamin D level: An independent risk factor for tuberculosis?

Kim, Ji Hae; Cho, Young Jae; Yoon, Ho Il; Song, Jung Han; Lee, Choon Tack; Lee, Jae Ho

doi:10.1016/j.clnu.2013.11.014

Cited by 37 publications

(38 citation statements)

References 28 publications

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“…Vitamin D deficiency is common in patients with active MTb (Kim et al 2013). In the pre-antibiotic era, cod liver oil, which is high in vitamin D, was used to treat MTb and other pulmonary infections (Watkins et al 2011).…”

Section: Respiratory Infectionsmentioning

confidence: 99%

An update on the association of vitamin D deficiency with common infectious diseases

Watkins

Lemonovich

Salata

2015

Can. J. Physiol. Pharmacol.

102

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Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.

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Section: Respiratory Infectionsmentioning

confidence: 99%

An update on the association of vitamin D deficiency with common infectious diseases

Watkins

Lemonovich

Salata

2015

Can. J. Physiol. Pharmacol.

102

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“…Although the function of vitamin D in immune responses in TB infection and treatment has been evaluated, no clear or consistent benefit of nutritional support in clinical improvement has been shown [56]. Only the vitamin D status and its supplementation in Korean TB patients using a variety of diagnostic methods have been assessed, but the results are inconsistent [57585960]. However, in cases of vitamin D supplementation, previous trials assessing sputum conversion could be misdirected if the major action of vitamin D in active TB disease is the mitigation of the inflammatory and immune responses [56].…”

Section: Assessment Of Nutritional Status Of Tb Patientsmentioning

confidence: 99%

Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations

et al. 2017

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Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the use of multiple drugs over long periods of time can cause frequent adverse drug reactions. In addition, some patients with drug-susceptible tuberculosis do not respond adequately to treatment and develop treatment failure and drug resistance. Response to tuberculosis treatment could be affected by multiple factors associated with the host-pathogen interaction including genetic factors and the nutritional status of the host. These factors should be considered for effective tuberculosis control. Therefore, therapeutic drug monitoring (TDM), which is individualized drug dosing guided by serum drug concentrations during treatment, and pharmacogenetics-based personalized dosing guidelines of anti-tuberculosis drugs could reduce the incidence of adverse drug reactions and increase the likelihood of successful treatment outcomes. Moreover, assessment and management of comorbid conditions including nutritional status could improve anti-tuberculosis treatment response.

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“…Vitamin D deficiency is common in active tuberculosis (11)(12)(13)(14). Vitamin D deficiency has also been associated with a susceptibility to tuberculosis infection, the conversion from latent to active tuberculosis, and the severity and relapse rate of tuberculosis disease (11)(12)(13)(14)(15)(16). Studies have shown that the 1,25-dihydroxyvitamin D 3 induction of antimycobacterial activity in monocytes is mediated in part by the upregulation of the antimicrobial peptide LL-37 (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 98%

High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

Tukvadze

Sanikidze

Kipiani

et al. 2015

The American Journal of Clinical Nutrition

110

104

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Low serum 25-hydroxyvitamin D level: An independent risk factor for tuberculosis?

Cited by 37 publications

References 28 publications

An update on the association of vitamin D deficiency with common infectious diseases

An update on the association of vitamin D deficiency with common infectious diseases

Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations

High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

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