Low sensitivity to thrombomodulin in patients with cirrhosis; Impact of factor VIII increase and protein C deficiency

Reversal of hypercoagulability in patients with HCV‐related cirrhosis after treatment with direct‐acting antivirals

“…In subsequent studies, however, multiple groups demonstrated increased thrombin generation in patients compared with controls using TM‐modified TGA . The hypercoagulable state of patients with cirrhosis relates, at least in part, to elevated plasma levels of factor VIII and decreased protein C which leads to an intrinsic resistance to the anticoagulant effect of TM in cirrhotic patients …”