Low Oxygen Enhancement Ratios for Strand Breaks Induced by Decays of 125I in DNA of Human T1 Cells Stored at 0°C

Schneeweiss, F.; Myers, D. K.; Tisljar-Lentulis, G.; Feinendegen, L. E.

doi:10.1093/rpd/13.1-4.237

Cited by 5 publications

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“…In various reports a temporary increase of the numbers of breaks during incubation of exposed culture cells at 37°C was observed (Bryant et al . 1984, Radford 1983, Schneeweiss et al . 1985 .…”

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confidence: 99%

‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells

Schneeweiss

Tisljar-Lentulis

Haustein

et al. 1987

International Journal of Radiation Biology and Related Studies

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confidence: 99%

‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells

Schneeweiss

Tisljar-Lentulis

Haustein

et al. 1987

International Journal of Radiation Biology and Related Studies

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“…The biological damage at cellular level produced by 12S I incorporated into the DNA of proliferating cells continues to draw attention of researchers (see reviews [1][2][3][4] and more recent papers [5][6][7][8]). The severe effects observed can be entirely attributed to the Auger transitions which follow the decay of 125 1.…”

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confidence: 99%

Chemical Effects of the Decay of ¹²⁵l in [¹⁴C , ¹²⁵l] lodobenzene in Different Solvents

Reiche¹,

Halpern²,

Stöcklin³

1988

Radiochimica Acta

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Doubly-labeled [U-14 C, 1,5 I] iodobenzene was synthesized, and its dilute solutions in hexane, benzene or methanol were stored at room or at low temperature to accumulate 1 ,S I decays. The 14 C-labeled products remaining after 1 "I had decayed were separated by gas chromatography and their yield determined radioanalytically. The fate of the highly excited [U-14 C]C,H S formed after the 155 I decay depends strongly on the matrix. In hexane aromatic rings decompose efficiently into fragments. In benzene they largely escape fragmentation, because of the ability of the surrounding ττ-electron molecules to facilitate intermolecular energy transfer. The results suggest that the charge built-up after the Auger transition and the energy deposited during neutralization, leading to super-excitation, is the main damaging event.

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125Iodine decay in DNA: A discussion of its effectiveness for the breaking of DNA strands

Tisljar-Lentulis

Schneeweiss

Feinendegen

1987

Radiat Environ Biophys

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125I incorporated in DNA is known to be exceptionally toxic. Values of D0 range from about 40 to about 90 decays for survival of mammalian cells. The effectiveness of 125I in DNA with respect to the induction of breaks of the DNA strands, however, appears to be comparatively low. The numbers of strand breaks per energy deposited in subnuclear cellular structures such as DNA is smaller for a disintegration of 125I than for gamma-rays. The difference in effectiveness diminishes with increasing mass of the considered sensitive volume. The apparent inefficiency of 125I-decay may, on one hand, result from a waste of local energy deposition. On the other hand, it may be caused by a multitude of local strand breaks (clusters) induced by 125I-decay which are measured as one break only by the conventionally applied techniques of strand break measurement. The apparent inefficiency of 125I may be evidence furthermore for the importance of considering not only the DNA as the sensitive target but with equal pertinence the gross sensitive volume, i.e. the whole cell nucleus. Further, for drawing meaningful comparisons, it may be necessary to take into consideration the microdosimetric event size distributions for the critical targets.

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Low Oxygen Enhancement Ratios for Strand Breaks Induced by Decays of 125I in DNA of Human T1 Cells Stored at 0°C

Cited by 5 publications

References 0 publications

‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells

‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells

Chemical Effects of the Decay of ¹²⁵l in [¹⁴C , ¹²⁵l] lodobenzene in Different Solvents

125Iodine decay in DNA: A discussion of its effectiveness for the breaking of DNA strands

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Low Oxygen Enhancement Ratios for Strand Breaks Induced by Decays of 125I in DNA of Human T1 Cells Stored at 0°C

Cited by 5 publications

References 0 publications

‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells

‘Periodical’ Pattern of Kinetics of DNA Strand Break Repair Following γ-irradiation of Human T1-cells

Chemical Effects of the Decay of 125l in [14C , 125l] lodobenzene in Different Solvents

125Iodine decay in DNA: A discussion of its effectiveness for the breaking of DNA strands

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Chemical Effects of the Decay of ¹²⁵l in [¹⁴C , ¹²⁵l] lodobenzene in Different Solvents