Abstract:Blood flow regulates vascular function by generating wall shear stress which impacts endothelial cell (EC) physiology. Whilst high laminar shear stress (HSS) maintains the functional integrity of the vasculature, low oscillatory shear stress (LOSS) evokes secretion of pro-thrombotic and pro-inflammatory components from ECs, thus promoting the development of cardiovascular disease (CVD). Pro-thrombotic and pro-inflammatory cargo are readily stored in endothelial-specific organelles termed Weibel-Palade bodies (… Show more
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