Low molecular weight gelator–dextran composites

Chen, Lin; Revel, Steven; Morris, Kyle L.; Spiller, David G.; Serpell, Louise C.; Adams, Dave J.

doi:10.1039/c0cc01842b

Cited by 68 publications

(62 citation statements)

References 26 publications

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“…Increasing to 5 mg/mL fucoidan an increase in intensity at low Q was visible and a clear deviation from I α Q −1 scattering to a Q −1 15 . power law which we interpret to be due to dilute large aggregates in the hydrogel.…”

Section: Resultsmentioning

confidence: 94%

Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

Boyd‐Moss

Long

et al. 2017

Sci Rep

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Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.

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Section: Resultsmentioning

confidence: 94%

Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

Boyd‐Moss

Long

et al. 2017

Sci Rep

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“…Smith et al prepared robust hybrid hydrogels via the assembly of a hydrogelator within polysaccharide hydrogel networks 21. Yang et al and Adams et al also showed that mixing supramolecular hydrogels with agarose and dextran leads to novel hybrid hydrogels with tunable mechanical strength 22,23. Recently, our group developed polymer enhanced hybrid self-recovering hydrogels via glucose oxidase mediated polymerization 24.…”

Section: Introductionmentioning

confidence: 99%

Printable hybrid hydrogel by dual enzymatic polymerization with superactivity

et al. 2016

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“…The mechanism of amplification by electrostatic coassembly is likely not exclusive to saccharides. Indeed, significant cooperative effects have been observed in co-assembly of Fmoc-peptides with (charged) proteins 23 and it will be interesting to investigate the possibility of adaptive reconfiguration in response to protein templating. More…”

Section: Discussionmentioning

confidence: 99%

“…20,21 The properties of peptide nanostructures can be altered dramatically by co-assembly 22,23 with macromolecules where specific interactions (e.g. electrostatic, aromatic stacking) and templating 24 might be utilized to direct the assembly process.…”

Section: Introductionmentioning

confidence: 99%

Sequence Adaptive Peptide–Polysaccharide Nanostructures by Biocatalytic Self-Assembly

Abul‐Haija

Ulijn

2015

Biomacromolecules

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Co-assembly of peptides and polysaccharides can give rise to formation of nanostructures with tunable morphologies. We show that in situ enzymatic exchange of a dipeptide sequences in aromatic peptide amphiphiles/polysaccharide co-assemblies enables dynamic formation and degradation of different nanostructures depending on the nature of the polysaccharide present. This is achieved in a one-pot system composed of Fmoc-cystic acid (CA), Fmoc-lysine (K) plus phenylalanine amide (F) in the presence of thermolysin which, through dynamic hydrolysis and amide formation gives rise to dynamic peptide library composed of the corresponding Fmocdipeptides (CAF and KF). When the cationic polysaccharide chitosan is added to this mixture, selective amplification of the CAF peptide is observed giving rise to formation of nanosheets through co-assembly. By contrast, upon addition of anionic heparin, KF is formed which gives rise to a nanotube morphology. The dynamic adaptive potential was demonstrated by sequential morphology changes depending on the sequence of polysaccharide addition. This first demonstration of the ability to access different peptide sequences and nanostructures depending on presence of biopolymers may pave the way to biomaterials that can adapt their structure and function and may be of relevance in design of materials able to undergo dynamic morphogenesis.

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Low molecular weight gelator–dextran composites

Abstract: Incorporation of dextran into a hydrogel formed using a low molecular weight dipeptide-conjugate gelator results in controlled modification of the material properties.

Cited by 68 publications

References 26 publications

Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

Printable hybrid hydrogel by dual enzymatic polymerization with superactivity

Sequence Adaptive Peptide–Polysaccharide Nanostructures by Biocatalytic Self-Assembly

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