Low level maize starch and sodium lauryl sulphate as release modifiers in carbopol 941 capsule matrix

Emeje, Martins; Ofoefule, S. I.

doi:10.4103/0973-8258.56272

Int J Green Pharm

2009

DOI: 10.4103/0973-8258.56272

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Low level maize starch and sodium lauryl sulphate as release modifiers in carbopol 941 capsule matrix

Martins Emeje¹,

S. I. Ofoefule²

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Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Asmanyl ® tablets showed faster absorption (t max 4.0 h) compared to the TPH formulation showing a t max value of 8.0 h. The C max and AUC values of TPH formulation were significantly (p < 0.05) higher than those for Asmanyl ® , revealing relative bioavailability of aboutWhen polymers of varying physicochemical properties are blended, they do not interact in the same way with water and drug molecules, resulting in different mobility of water and drug within the polymeric networks (1)(2)(3)(4). Polymer blends sensitive to the surrounding environment may be of particular interest for many applications (5)(6)(7).…”

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“…These additives are capable of interacting with the polymer to attenuate release of the incorporated active drug (7,8). Theophylline, an alkaloid found in the leaves of Camellia sinensis is used clinically as a bronchodilator in the management of chronic obstructive pulmonary disease (9).…”

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“…The use of Carbopols in drug delivery, especially in sustained release formulations, may sometimes require other additives because of the high drug release retardant effect encountered with the polymer (7,8). These additives are capable of interacting with the polymer to attenuate release of the incorporated active drug (7,8).…”

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Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

Emeje¹,

John-Africa²,

Isimi³

et al. 2012

Acta Pharmaceutica

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Sustained release (SR) dosage forms enable prolonged and continuous deposition of the drug in the gastrointestinal (GI) tract and improve the bioavailability of medications characterized by a narrow absorption window. In this study, a new strategy is proposed for the development of SR dosage forms for theophylline (TPH). Design of the delivery system was based on a sustained release formulation, with a modified coating technique and swelling features aimed to extend the release time of the drug. Different polymers, such as Carbopol 71G (CP), sodium carboxymethylcellulose (SCMC), ethylcellulose (EC) and their combinations were tried. Prepared matrix tablets were coated with a 5 % (m/m) dispersion of Eudragit (EUD) in order to get the desired sustained release profile over a period of 24 h. Various formulations were evaluated for micromeritic properties, drug concentration and in vitro drug release. It was found that the in vitro drug release rate decreased with increasing the amount of polymer. Coating with EUD resulted in a significant lag phase in the first two hours of dissolution in the acidic pH of simulated gastric fluid (SGF) due to decreased water uptake, and hence decreased driving force for drug release. Release became faster in the alkaline pH of simulated intestinal fluid (SIF) owing to increased solubility of both the coating and matrixing agents. The optimized formulation was subjected to in vivo studies in rabbits and the pharmacokinetic parameters of developed formulations were compared with the commercial (Asmanyl ® ) formulation. Asmanyl ® tablets showed faster absorption (t max 4.0 h) compared to the TPH formulation showing a t max value of 8.0 h. The C max and AUC values of TPH formulation were significantly (p < 0.05) higher than those for Asmanyl ® , revealing relative bioavailability of about 136.93 %. Our study demonstrated the potential usefulness of eudraginated polymers for the oral delivery of the sparingly soluble drug theophylline.

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Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

Emeje¹,

John-Africa²,

Isimi³

et al. 2012

Acta Pharmaceutica

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Natural Antidiabetic Compound for the Therapeutic Management of Diabetes Mellitus and Its Drug Delivery System

Emeje

Boyi

Obidike

et al. 2011

Journal of Dietary Supplements

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A single tablet dosage form containing the freeze-dried aqueous leaf extract of Vernonia amygdalina (AD1), suitable for use in the therapeutic management of diabetes mellitus, has been developed. The compaction characteristics of the extract were studied using the Heckel equation. The mechanical properties as well as disintegration and dissolution profile of the compacts were also assessed. The results showed that AD1 exhibited very low densification due to dye filling and addition of filler-binders contributed significantly to their subsequent densification. The tablets produced had good mechanical properties. Of the three filler-binders tested, tablets containing Avicel had the shortest disintegration time of about 5 min, while tablets without any filler-binder had the longest disintegration time of 50 min. Dissolution results (T(90%)) showed that tablets containing Avicel released 100% of the extract in less than 15 min proving to be the most suitable in acute diabetes. The order of dissolution is Avicel > maize starch > lactose > extract. It is concluded that incorporation of Avicel as a filler-binder in AD1 preparation produced tablets of suitable compaction properties and ensured adequate drug release for the therapeutic management of diabetes mellitus.

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Low level maize starch and sodium lauryl sulphate as release modifiers in carbopol 941 capsule matrix

Cited by 2 publications

References 9 publications

Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

Eudraginated polymer blends: A potential oral controlled drug delivery system for theophylline

Natural Antidiabetic Compound for the Therapeutic Management of Diabetes Mellitus and Its Drug Delivery System

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