Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device–Controlled Multicenter Trial

Kim, Hyojin; Choi, Jee Woong; Kim, Jun Young; Shin, Jung Won; Lee, Seok-jong; Huh, Chul

doi:10.1111/dsu.12200

Cited by 126 publications

(100 citation statements)

References 17 publications

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“…[67] Moreover, combining LLLT with topical minoxidil solution and oral finasteride may act synergistic to enhance hair growth. Due to the known beneficial effect on wound healing, it is conceivable that LLLT as an adjunctive therapy in hair transplant surgery may also reduce postoperative shedding, reduce healing time, and increase graft patency.…”

Section: Resultsmentioning

confidence: 99%

“…These effects in turn lead to increased cellular proliferation, modulation in levels of cytokines, growth factors and inflammatory mediators, and increased tissue oxygenation. While the effects of these biochemical and cellular changes have broadly been studied in both animal models and clinical studies with patients, and have shown benefits in diverse conditions, such as increased healing in chronic wounds, improvements in sports injuries and carpal tunnel syndrome, pain reduction in arthritis and neuropathies, and amelioration of damage after heart attacks, stroke, nerve injury and retinal toxicity,[79] the effects on hair growth stimulation have only recently gained the attention of the scientific community.…”

Section: Discussionmentioning

confidence: 99%

“…reported an increase of hair density with the use of LLLT, when compared to the sham device in a 24-week, randomized, double-blind, sham-device-controlled trial. [7]…”

Section: Introductionmentioning

confidence: 99%

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Use of low-level laser therapy as monotherapy or concomitant therapy for male and female Androgenetic alopecia

Munck¹,

Gavazzoni²,

Trüeb³

2014

Int J Trichol

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Background:Androgenetic alopecia (AGA) is the most common form of hair loss in men and in women. Currently, minoxidil and finasteride are the treatments with the highest levels of medical evidence, but patients who exhibit intolerance or poor response to these treatments are in need of additional treatment modalities.Objective:The aim was to evaluate the efficacy and safety of low-level laser therapy (LLLT) for AGA, either as monotherapy or as concomitant therapy with minoxidil or finasteride, in an office-based setting.Materials and Methods:Retrospective observational study of male and female patients with AGA, treated with the 655 nm-HairMax Laser Comb®, in an office-based setting. Efficacy was assessed with global photographic imaging.Results:Of 32 patients (21 female, 11 male), 8 showed significant, 20 moderate, and 4 no improvement. Improvement was seen both with monotherapy and with concomitant therapy. Improvement was observed as early as 3 months and was sustained up to a maximum observation time of 24 months. No adverse reactions were reported.Conclusions:LLLT represents a potentially effective treatment for both male and female AGA, either as monotherapy or concomitant therapy. Combination treatments with minoxidil, finasteride, and LLLT may act synergistic to enhance hair growth.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Use of low-level laser therapy as monotherapy or concomitant therapy for male and female Androgenetic alopecia

Munck¹,

Gavazzoni²,

Trüeb³

2014

Int J Trichol

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“…Finasteride with or without minoxidil is equally well-tolerated and increased hair density in a small cohort of adolescent boys (100). Recent studies have also demonstrated efficacy of low-level laser therapy for adult patients of both genders with AGA (104–106). …”

Section: Other Patterned Alopeciamentioning

confidence: 99%

A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents

Liu

Senna

2017

Front. Med.

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Hair loss or alopecia is a common and distressing clinical complaint in the primary care setting and can arise from heterogeneous etiologies. In the pediatric population, hair loss often presents with patterns that are different from that of their adult counterparts. Given the psychosocial complications that may arise from pediatric alopecia, prompt diagnosis and management is particularly important. Common causes of alopecia in children and adolescents include alopecia areata, tinea capitis, androgenetic alopecia, traction alopecia, trichotillomania, hair cycle disturbances, and congenital alopecia conditions. Diagnostic tools for hair loss in children include a detailed history, physical examination with a focused evaluation of the child's hair and scalp, fungal screens, hair pull and tug test, and if possible, light microscopy and/or trichoscopy. Management of alopecia requires a holistic approach including psychosocial support because treatments are only available for some hair loss conditions, and even the available treatments are not always effective. This review outlines the clinical presentations, presents a diagnostic algorithm, and discusses management of these various hair loss disorders.

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“…More studies, including RCT are needed to support its efficacy. In addition, the optimum dose, wavelength, coherence and dosimetric parameters remain to be determined [113,116,117,110].…”

Section: Low-level Laser Therapymentioning

confidence: 99%

Androgenetic Alopecia: a Review and Emerging Treatments

Alves¹

2017

CRDOA

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Androgenetic Alopecia (AGA) is the most common noncicatricial alopecia that leads to the progressive miniaturization of the hair follicle. Scalp terminal hairs are converted into vellus hairs, primarily due to two factors: genetic predisposition and hormonal stimulation.The incidence and prevalence of AGA increases with age. The onset of AGA is gradual, and when this pathology progresses, the anagen phase shortens and the telogen phase remains constant. The shedding area varies from patient to patient and is usually most marked at the vertex in men, while women with AGA generally lose hair diffusely over the crown.Topical minoxidil and oral finasteride (5-alpha-reductase type II inhibitor) are the gold-standard therapies for AGA and are currently the only Food and Drug Administration (FDA)-approved drugs for the treatment of AGA.The currently available treatments for AGA are sometimes perceived as having limited effectiveness; therefore, the identification of new therapies for this pathology is of utmost importance.This article aims to review the pathogenesis, diagnosis of AGA and all the new emerging treatments for this entity in order to prevent its progression and improve the results of this pathology.

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Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device–Controlled Multicenter Trial

Abstract: LLLT could be an effective treatment for AGA.

Cited by 126 publications

References 17 publications

Use of low-level laser therapy as monotherapy or concomitant therapy for male and female Androgenetic alopecia

Use of low-level laser therapy as monotherapy or concomitant therapy for male and female Androgenetic alopecia

A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents

Androgenetic Alopecia: a Review and Emerging Treatments

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