Low-Intensity Pulsed Ultrasound Attenuates LPS-Induced Neuroinflammation and Memory Impairment by Modulation of TLR4/NF-κB Signaling and CREB/BDNF Expression

Chen, Tao Tao; Lan, Tsuo Hung; Yang, Feng

doi:10.1093/cercor/bhy039

Cited by 59 publications

(51 citation statements)

References 33 publications

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“…In this context, it is interesting to note that the beneficial effect of non-steroidal anti-inflammatory drugs (NSAID) on AD incidence has been noted early in in t’ Veld et al (2001) and Zandi et al (2002). Apart from human studies in animal models, it has been documented that neurotrophin treatment caused a decrease in pro-inflammatory cytokines IL-1β IL-6 (TNF-α), elevation of brain-derived neurotrophic factor (BDNF), and less cognitive impairment, Aβ deposition, and microglial activation (Fang et al, 2019). Interferon-β1a (IFNβ1a) is largely used to attenuate the progression of multiple sclerosis and its anti-inflammatory effect could be beneficial also for AD patients.…”

Section: Inflammation In Admentioning

confidence: 99%

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Španić

Horvat

Hof

et al. 2019

Front. Aging Neurosci.

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Uncontrolled immune response in the brain contributes to the progression of all neurodegenerative disease, including Alzheimer’s disease (AD). Recent investigations have documented the prion-like features of tau protein and the involvement of microglial changes with tau pathology. While it is still unclear what sequence of events is causal, it is likely that tau seeding potential and microglial contribution to tau propagation act together, and are essential for the development and progression of degenerative changes. Based on available evidence, targeting tau seeds and controlling some signaling pathways in a complex inflammation process could represent a possible new therapeutic approach for treating neurodegenerative diseases. Recent findings propose novel diagnostic assays and markers that may be used together with standard methods to complete and improve the diagnosis and classification of these diseases. In conclusion, a novel perspective on microglia-tau relations reveals new issues to investigate and imposes different approaches for developing therapeutic strategies for AD.

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Section: Inflammation In Admentioning

confidence: 99%

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Španić

Horvat

Hof

et al. 2019

Front. Aging Neurosci.

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“…Furthermore, previous results suggest that LCN2 may be an important pathogenic biomolecule involved in PD [21]. LIPUS has been shown to inhibit the lipopolysaccharide (LPS)-induced activation of TLR4/NF-B inflammatory signaling and affected the proinflammatory responses of microglia [28,41]. In addition to demonstrating LCN2 upregulation in the 6-OHDA-treated rats of PD, we investigated whether LIPUS stimulation in the 6-OHDA-treated rats of PD prevented the ensuing production of neurotoxic cytokine such as IL-1 ( Figure 5).…”

Section: Discussionmentioning

confidence: 98%

“…Herein, we chose a 1-MHz ultrasound transducer with a set of parameters based on our previous studies [26,28]. A wide range of bio-effects can be produced by LIPUS stimulation, depending on multiple parameters, including frequency, intensity, burst duration, pulse repetition frequency, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Compared with rTMS or tDCS, transcranial ultrasound stimulation (TUS) has a deeper penetration ability in the brain with a higher spatial resolution [25]. Studies have suggested that low-intensity pulsed ultrasound (LIPUS) may hold a great promise for the modulation of brain function and reversal of neurological dysfunction [26][27][28]. To clarify the neuroprotective and anti-inflammatory effect of LIPUS on SNpc DA neurons after LIPUS treatment, this study investigated motor functions and tyrosine hydroxylase (TH)-immunoreactive DA neurons in SNpc and striatum.…”

Section: Introductionmentioning

confidence: 99%

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WITHDRAWN: Low-intensity pulsed ultrasound improves behavioral functions and alleviates neuroinflammation in a rat model of Parkinson’s disease

Yang

Sung

Chiang

et al. 2020

Preprint

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BackgroundParkinson’s disease (PD) is characterized by a reduction of dopamine level in the substantia nigra pars compacta (SNpc) and striatum of the brain. Low-intensity pulsed ultrasound (LIPUS) has been demonstrated recently as a non-invasive neuromodulation tool in a number of fields. LIPUS has also been reported to improve behavioral functions in PD animal models; however, the effect of LIPUS stimulation on the neurotrophic factors and neuroinflammation has not yet been addressed.MethodsPD rat model was built by injection of 6-hydroxydopamine (6-OHDA) in two sites in the right striatum. The levels of neurotrophic factors and lipocalin-2 (LCN2)-induced neuroinflammation were quantified using a western blot. Rotational test and cylinder test were conducted biweekly for eight weeks. The safety of LIPUS was assessed using Hematoxylin and Esosin (H&E) staining and Nissl staining.ResultsWhen the 6-OHDA+LIPUS and 6-OHDA groups were compared, the locomotor function of the 6-OHDA+LIPUS rats was significantly improved. After LIPUS stimulation, the number of neurons was remarkably increased in the striatum and SNpc of lesioned rats. Unilateral LIPUS stimulation did not increase brain-derived neurotrophic factor (BDNF) in the striatum and SNpc of lesioned rats. In contrast, unilateral LIPUS stimulation increased glial cell line-derived neurotrophic factor (GDNF) protein 1.98-fold unilaterally in the SNpc. Additionally, LCN2-induced neuroinflammation can be attenuated following LIPUS stimulation.ConclusionsOur data indicated that LIPUS stimulation increased GDNF and dopaminergic (DA) neuron density in the 6-OHDA-induced rat model of PD. Moreover, this technology attenuated proinflammatory mediators and reversed behavioral indicators of PD-associated motor dysfunction with no evidence of brain tissue injury. These results show that LIPUS stimulation may be a potential therapeutic tool against PD via enhancement of GDNF level and inhibition of inflammatory responses in the SNpc of the brain.

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“…Su et al demonstrated that post-LIPUS treatment reduced brain edema and ameliorated the behavioral and pathological outcomes in a traumatic brain injury mice model [15]. Other investigators further demonstrated the importance of brain-derived neurotrophic factor (BDNF) induction after LIPUS treatment in neuronal injury models [16,17,18,19,20,21]. Liu et al also found the positive effects of LIPUS treatment on ischemic stroke via BDNF induction in rat models [22].…”

Section: Introductionmentioning

confidence: 99%

Low Intensity Pulsed Ultrasound Prevents Recurrent Ischemic Stroke in a Cerebral Ischemia/Reperfusion Injury Mouse Model via Brain-derived Neurotrophic Factor Induction

Yang

Chen

et al. 2019

IJMS

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The incidence of stroke recurrence is still higher despite the advanced progression of therapeutic treatment and medical technology. Low intensity pulsed ultrasound (LIPUS) has been demonstrated to possess therapeutic effects on neuronal diseases and stroke via brain-derived neurotrophic factor (BDNF) induction. In this study, we hypothesized that LIPUS treatment possessed therapeutic benefits for the improvement of stroke recurrence. Adult male C57BL/6J mice were subjected to a middle cerebral artery occlusion (MCAO) surgery and then followed to secondary MCAO surgery as a stroke recurrence occurred after nine days from the first MCAO. LIPUS was administered continuously for nine days before secondary MCAO. LIPUS treatment not only decreased the mortality but also significantly moderated neuronal function injury including neurological score, motor activity, and brain pathological score in the recurrent stroke mice. Furthermore, the administration of LIPUS attenuated the apoptotic neuronal cells and increased Bax/Bcl-2 protein expression ratio and accelerated the expression of BDNF in the brain of the recurrent stroke mice. Taken together, these results demonstrate for the first time that LIPUS treatment arouses the expression of BDNF and possesses a therapeutic benefit for the improvement of stroke recurrence in a mouse model. The neuroprotective potential of LIPUS may provide a useful strategy for the prevention of a recurrent stroke.

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Low-Intensity Pulsed Ultrasound Attenuates LPS-Induced Neuroinflammation and Memory Impairment by Modulation of TLR4/NF-κB Signaling and CREB/BDNF Expression

Cited by 59 publications

References 33 publications

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation

WITHDRAWN: Low-intensity pulsed ultrasound improves behavioral functions and alleviates neuroinflammation in a rat model of Parkinson’s disease

Low Intensity Pulsed Ultrasound Prevents Recurrent Ischemic Stroke in a Cerebral Ischemia/Reperfusion Injury Mouse Model via Brain-derived Neurotrophic Factor Induction

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