Low human papillomavirus prevalence in head and neck cancer: results from two large case–control studies in high-incidence regions

Ribeiro, Karina de Cássia Braga; Levi, José Eduardo; Pawlita, Michael; Koifman, Sérgio; Matos, Elena; Eluf-Neto, José; Wünsch-Filho, Victor; Curado, María Paula; Shangina, Oxana; Заридзе, Давид; Szeszenia-Da̧browska, Neonila; Lissowska, Jolanta; Daudt, Alexander W.; Menezes, Ana; Bencko, Vladimír; Mateș, Dana; Fernández, Leticia; Fabiánovà, Eleonóra; Gheit, Tarik; Tommasino, Massimo; Boffetta, Paolo; Brennan, Paul; Waterboer, Tim

doi:10.1093/ije/dyq249

Cited by 163 publications

(176 citation statements)

References 55 publications

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“…5 Graphic representation for microvessel density/mm2 for tumor stroma (MD/TS) and microvessel density/mm2 for tumor (MD/T) in esophageal adenocarcinoma we studied Chung (2007) supports the same opinion, reporting that p53 can be considered a marker of transformation from Barrett's esophagus into esophageal adenocarcinoma [1]. P53 mutations were associated with low histological tumor differentiation and low survival rate with esophageal adenocarcinoma [7,9,10], these results coming to support the results of our study-intensity marking (+++) of p53 in poorly differentiated esophageal adenocarcinoma.…”

Section: Discussionsupporting

confidence: 61%

Neoangiogenesis. Assessment in Esophageal Adenocarcinomas

2014

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Esophageal cancer has always been subject of research for various studies. According to some authors, esophageal cancer represents the 10th leading cause of cancer in the world with a 5-year survival of 10 %. In terms of anatomopathological form of the esophageal neoplasia, the literature mainly describes two major pathological types: adenocarcinoma and esophageal squamous cell carcinoma. Lately there has been an increased incidence of esophageal adenocarcinoma. The aim of the present work was to study neoangiogenesis in esophageal adenocarcinomas. The study was conducted on 40 cases diagnosed and surgically treated. Subsequently, fragment processing was performed using various immunohistochemical staining and marking with CD34 and p53 antigen. Later, quantitative measurements were performed, and images were taken using a microscope imaging system. In the end of the procedures, the professional program PRODIT 5.2. was applied. The study of the vascular system in the esophageal epithelial tumors revealed an axis consisting of three elements which have a mutual induction process: inflammatory infiltrate-neoangiogenesis-fibrosis, with significant differences between the three degrees of differentiation. A significant increase in tumor micro vascular density was present together with the increasing of the histological grading, with an inverse correlation with the degree of differentiation and directly proportional to the risk of malignancy.

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Section: Discussionsupporting

confidence: 61%

Neoangiogenesis. Assessment in Esophageal Adenocarcinomas

2014

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“…In North America, the proportion of HPV-positive OPSCC ranges between 60 and 70%, 6 in Australia it is reported to be 46%, in Asia 25-50%, and in South America 4.4%. [7][8][9] In Western European countries including United Kingdom, France, and Germany, reported proportions vary between 40 and 60%, and The Netherlands appeared to have the lowest proportion of about 20% in 2000-2006, but apparently increasing to 30% in 2010. 8,10,11 Studies in Northern Europe have reported higher proportions, up to 93% in tonsillar carcinomas in Sweden.…”

mentioning

confidence: 99%

Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990–2009)

Rodrigo

Heideman

Fresno

et al. 2013

Intl Journal of Cancer

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Recent studies support an important role for human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (OPSCC), although the incidence varies widely depending on the geographic location and time period studied. The aim of this study was to determine the proportion of HPV in a large cohort of OPSCC in northern Spain in the years 1990-2009. Clinical records and paraffin embedded tumor specimens of 248 consecutive patients surgically treated for OPSCC (140 tonsillar and 108 base of tongue) between 1990 and 2009 were retrieved. OPSCC cases were histomorphologically evaluated, and protein expression of p16 and p53 was analyzed by immunohistochemistry. Detection of high-risk HPV DNA was performed by GP51=61-PCR and in situ hybridization (ISH). Thirty cases (12%) were positive for p16 immunostaining, of which eight (3.2% of the total series) were found positive for HPV type 16 by genotyping of GP5161-PCR products. All HPV GP51=61-PCRpositive tumors were p53-immunonegative, seven had a basaloid morphology and seven were also positive by HPV ISH. Presence of HPV correlated inversely with tobacco and alcohol consumption (p < 0.001), but not with age of onset of OPSCC. Overall survival was better in the HPV-positive group, although not statistically significant (p 5 0.175). OPSCC patients in northern Spain demonstrated a low involvement of HPV, increasing (although not significantly, p 5 0.

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“…Despite using the most sensitive method (PCR), we still observed a large variation in HPV detection rates, which can be explained by the relationship between results and sample sizes. In fact, the Kleist et al study observed an 80% positivity among 5 samples, while Ribeiro et al only detected HPV in 3.8% of cases among 78 tumors (Kleist et al, 2000;Ribeiro et al, 2011).…”

Section: Human Papillomavirus and Related Diseases -From Bench To Bedmentioning

confidence: 93%

“…Thus, to obtain the most accurate results for the relationship between HPV and OSCC, future studies should only select biopsied tissues for HPV testing. In addition to the previously mentioned reviews, studies examining HPV infection in OSCC reported a wide range of detection rates from 0 to 61% (Herrero et al, 2003;Koskinen et al, 2003;Mishra et al, 2006;Ribeiro et al, 2011;Smith et al, 2004a). Varying sampling techniques together with widely divergent PCR methods across the studies explain most of this variability.…”

Section: Incidence In Oral Tumorsmentioning

confidence: 98%

“…Based on the literature, we observed a prevalence ranging from 0% to 82% (Ernoux et al, 2011;Hafkamp et al, 2003;Ringström et al, 2002). In fact, some authors failed to show prevalence higher than 10% (Gillison et al, 2000;Hafkamp et al, 2003;Ribeiro et al, 2011;Ringström et al, 2002;Stremlau et al, 1987), whereas others found prevalence greater than 50% (Arndt et al, 1992;Ernoux et al, 2011;Kleist et al, 2000;Koskinen et al, 2003;Tyan et al, 1993). Recently, we examined the presence of HPV DNA in a series of 75 patients with stage IV hypopharyngeal SCC (Ernoux et al, 2011).…”

Section: Incidence In Hypopharyngeal Tumorsmentioning

confidence: 99%

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