Low-grade inflammation markers in children and adolescents: Influence of anthropometric characteristics and CRP and IL6 polymorphisms

Todendi, Pâmela Ferreira; Possuelo, Lia Gonçalves; Klinger, Elisa Inês; Reuter, Cézane Priscila; Burgos, Míria Suzana; Moura, Dinara Jaqueline; Fiegenbaum, Marilu; Valim, Andréia Rosane de Moura

doi:10.1016/j.cyto.2016.09.007

Cited by 34 publications

(24 citation statements)

References 40 publications

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“…Our results are in agreement with prior studies that have consistently demonstrated an association between anthropometric measures of excess total and regional adiposity and CRP among both males and females and Hispanic‐only as well as multiethnic cohorts of children and adolescents ,. Body fat (%), by more direct measures (DXA and air displacement plethysmography), has also been significantly and positively associated with CRP among children and adolescents across studies ,, though Hispanic representation has been limited. In a study that estimated adiposity by both anthropometry and air displacement plethysmography, results were aligned with ours, though direct comparisons between BMI and body fat were not made.…”

Section: Discussionsupporting

confidence: 92%

Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Bea

Funk

Hetherington‐Rauth

et al. 2018

Obesity

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Objective To compare total and regional estimates of body composition, by direct and indirect techniques, for the optimal prediction of CRP among young (9–12 year old), Hispanic girls ( N =232). Methods Standard anthropometric techniques were used to measure height, weight, and waist circumference. Dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) assessed body composition. Fasting serum CRP was measured by the Beckman Coulter AU5812 Clinical Chemistry Analyzer. Associations between each total and regional body composition parameter and CRP were tested using linear regression (log-transformed, continuous CRP) and ordinal logistic regression (CRP < 1.0, ≥1.0–2.9, and ≥ 3.0 mg/L), controlling for maturation, dietary energy, physical activity, and medications. Results All measures of total and regional body fat were positively associated with CRP (P<0.0001), except for intermuscular fat by pQCT. There were no clinically relevant differences in their association with CRP between anthropometric (BMI; waist circumference) and DXA-derived (total fat and regional fat: trunk, gynoid, android fat, leg) measures of fat. Conclusions Measurement of body habitus in Hispanic girls, by multiple commonly available means, predicts CRP equally well.

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Section: Discussionsupporting

confidence: 92%

Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Bea

Funk

Hetherington‐Rauth

et al. 2018

Obesity

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“…It is well known that such proteins are not only surrogate markers but are also directly involved in the pathophysiology of deleterious processes leading to end organ damage [18]. In children, other parameters are also found to linearly correlate with BMI and include blood polymorphonuclear count [19], IL-6, or CRP [20]. Hence, although the correlation coefficients between BMI and CP are not very strong, our data provide further support to our contention that BMI z-score in children may associate with later adverse events even among children whose body weight is within the normative range.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis

Grand

Rochette

Dutheil

et al. 2020

JCM

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Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated circulating levels of calprotectin. However, associations between body mass index (BMI) and calprotectin levels have not been explored in otherwise healthy children. Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed and Cochrane Library database up to July 2019. Healthy children’s blood calprotectin values were extracted, and potential correlations were explored. Results: A total of six studies that included data on 593 healthy children were identified. Median calprotectin value was 900.0 (482.0; 1700) ng·mL−1. Multivariable analysis showed no significant associations with age, sample type (serum vs. plasma), or sex. In contrast, a significant effect of BMI z-score (p < 0.001) emerged. Indeed, a positive correlation between BMI z-score and CP, was detected in girls (R: 0.48; p < 0.001) and boys (R: 0.39; p < 0.001). Conclusion: Calprotectin blood levels correlate with the degree of adiposity in healthy children, but are not affected by age, sex, or sample type (serum or plasma).

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“…However, not only elderly pathologies are associated with the presence of low systemic inflammation. As systemic inflammation has also been reported in children and teenagers with weight problems [ 4 ], it is now clear that the persistence of the underlying condition and molecular mechanisms that trigger it should be taken into consideration in tandem with low chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome

Mihai

Codrici

Popescu

et al. 2018

Journal of Immunology Research

421

361

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Persistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients. Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting 10–15% of the population, and its prevalence is constantly growing. Due to its insidious nature, CKD is rarely diagnosed in early stages, and once developed, its progression is unfortunately irreversible. There are many factors that contribute to the setting of the inflammatory status in CKD, including increased production of proinflammatory cytokines, oxidative stress and acidosis, chronic and recurrent infections, altered metabolism of adipose tissue, and last but not least, gut microbiota dysbiosis, an underestimated source of microinflammation. In this scenario, a huge step forward was made by the increasing progression of omics approaches, specially designed for identification of biomarkers useful for early diagnostic and follow-up. Recent omics advances could provide novel insights in deciphering the disease pathophysiology; thus, identification of circulating biomarker panels using state-of-the-art proteomic technologies could improve CKD early diagnosis, monitoring, and prognostics. This review aims to summarize the recent knowledge regarding the relationship between inflammation and CKD, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy, raised on the background of an inflammatory condition.

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Low-grade inflammation markers in children and adolescents: Influence of anthropometric characteristics and CRP and IL6 polymorphisms

Cited by 34 publications

References 40 publications

Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis

Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome

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