Low-grade clear cell eccrine carcinoma

Solid carcinoma is a variant of microcystic adnexal carcinoma: A 14‐case series

“…Regarding clear cells, these are present focally in 42% of our cases. Cooper et al have elegantly described them . In previous articles, neoplasms named “clear cell syringoid eccrine carcinoma” or “clear cell syringoid carcinoma,” fit within the diagnosis of solid variant of MAC .…”

Clear‐cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm

“…D, Higher magnification demonstrating that the content of the clear cells was digested by diastase. porocarcinoma, 8,9 clear cell syringoid carcinoma, 10,11 microcystic adnexal carcinoma 12,13 and clear cell BCC. [14][15][16] Clear cell syringoma 3 stroma is more abundant and appears, at least focally, composed of thick bundles of sclerotic collagen.…”

“…The histopathological differential diagnosis of clear‐cell dermal duct tumour includes clear cell syringoma, 3 tricholemmoma, 6 clear cell hidradenoma, 7 clear cell porocarcinoma, 8,9 clear cell syringoid carcinoma, 10,11 microcystic adnexal carcinoma 12,13 and clear cell BCC 14–16 . Clear cell syringoma 3 is a rare histopathological variant of syringoma, mostly seen in diabetics, characterized histopathologically by ducts and solid aggregations of clear or pale cells.…”

“…In contrast with clear cell porocarcinoma, the architectural and cytological features of clear cell dermal duct tumour, as well as patient follow‐up, indicate that clear cell dermal duct tumour shows benign biological behaviour. Clear cell syringoid carcinoma 10,11 is a low‐grade adenocarcinoma characterized histopathologically by small solid aggregations and small ductal structures embedded in a desmoplastic stroma that involves the full thickness of the dermis and extends to the subcutaneous tissue. Although neoplastic aggregations of clear cell syringoid carcinoma show no cytological atypia, the lesion shows architectural features of a malignant neoplasm, because it may ulcerate the epidermis, obliterate the pre‐existing structure of the dermis and frequently shows perineural and endoneural involvement in deeper areas.…”

Clear Cell Proliferations of the Skin: A Histopathologic Review

“…19) and, as malignant counterpart of clear cell syringoma, does not seem to be related to diabetes mellitus. [93][94][95] Immunohistochemical study reveals positivity for CKs 7, 8, 18, and 19 as well as CK5 and CK14. EMA and CEA are positive in the luminal border, and p63 is expressed in the periphery of some ductal structures.…”