Low glycaemic index diets for coronary heart disease

The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein

“…Our results do not agree with meta-analyses showing that low-GI diets reduce HbA 1c or fructosamine in subjects with or without diabetes (18,42,43). The meta-analyses were based largely on studies lasting 3 mo, and it is possible that the effects of a low-GI diet on HbA 1c in T2DM patients are not sustained for 1 y.…”

The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein

“…Our results do not agree with meta-analyses showing that low-GI diets reduce HbA 1c or fructosamine in subjects with or without diabetes (18,42,43). The meta-analyses were based largely on studies lasting 3 mo, and it is possible that the effects of a low-GI diet on HbA 1c in T2DM patients are not sustained for 1 y.…”

Should glycemic index and glycemic load be considered in dietary recommendations?

“…The positive effects of low GI or GL diets on TC 10,11,13 and LDL‐C 11,13 reported in meta‐analyses of intervention studies were not generally substantiated by the observational studies we identified (Tables 3 and 4). A possible explanation for the difference is related to the study populations, because the meta‐analyses included studies performed on subjects with disturbed metabolism; some even had this as an inclusion criterion 9,10,13 . In observational studies it is most often assumed that participants are healthy at baseline.…”

Dietary carbohydrate, glycemic index, and glycemic load and the risk of colorectal cancer in the BCDDP cohort

“…Glycemic index has shown association with non-insulin dependent diabetes mellitus (NIDDM) [19][20][21] and, in some studies, associations with cardiovascular disease (CVD)-related outcomes [22,23], consistent with the theory that these measures of carbohydrate quantity and quality are related to insulin resistance. However, there is limited evidence linking glycemic index, glycemic load, or carbohydrate with cancer per se.…”

The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein

“…Our results do not agree with meta-analyses showing that low-GI diets reduce HbA 1c or fructosamine in subjects with or without diabetes (18,42,43). The meta-analyses were based largely on studies lasting 3 mo, and it is possible that the effects of a low-GI diet on HbA 1c in T2DM patients are not sustained for 1 y.…”

Should glycemic index and glycemic load be considered in dietary recommendations?

“…The positive effects of low GI or GL diets on TC 10,11,13 and LDL‐C 11,13 reported in meta‐analyses of intervention studies were not generally substantiated by the observational studies we identified (Tables 3 and 4). A possible explanation for the difference is related to the study populations, because the meta‐analyses included studies performed on subjects with disturbed metabolism; some even had this as an inclusion criterion 9,10,13 . In observational studies it is most often assumed that participants are healthy at baseline.…”

Dietary carbohydrate, glycemic index, and glycemic load and the risk of colorectal cancer in the BCDDP cohort

“…Glycemic index has shown association with non-insulin dependent diabetes mellitus (NIDDM) [19][20][21] and, in some studies, associations with cardiovascular disease (CVD)-related outcomes [22,23], consistent with the theory that these measures of carbohydrate quantity and quality are related to insulin resistance. However, there is limited evidence linking glycemic index, glycemic load, or carbohydrate with cancer per se.…”

The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein

“…Our results do not agree with meta-analyses showing that low-GI diets reduce HbA 1c or fructosamine in subjects with or without diabetes (18,42,43). The meta-analyses were based largely on studies lasting 3 mo, and it is possible that the effects of a low-GI diet on HbA 1c in T2DM patients are not sustained for 1 y.…”

Should glycemic index and glycemic load be considered in dietary recommendations?

“…The positive effects of low GI or GL diets on TC 10,11,13 and LDL‐C 11,13 reported in meta‐analyses of intervention studies were not generally substantiated by the observational studies we identified (Tables 3 and 4). A possible explanation for the difference is related to the study populations, because the meta‐analyses included studies performed on subjects with disturbed metabolism; some even had this as an inclusion criterion 9,10,13 . In observational studies it is most often assumed that participants are healthy at baseline.…”

Dietary carbohydrate, glycemic index, and glycemic load and the risk of colorectal cancer in the BCDDP cohort

“…Glycemic index has shown association with non-insulin dependent diabetes mellitus (NIDDM) [19][20][21] and, in some studies, associations with cardiovascular disease (CVD)-related outcomes [22,23], consistent with the theory that these measures of carbohydrate quantity and quality are related to insulin resistance. However, there is limited evidence linking glycemic index, glycemic load, or carbohydrate with cancer per se.…”