Low fructosamine and mortality – A long term follow-up of 215,011 non-diabetic subjects in the Swedish AMORIS study

Malmström, Håkan; Wändell, Per; Holzmann, Martin J.; Ärnlöv, Johan; Jungner, Ingmar; Hammar, Niklas; Walldius, Göran; Carlsson, Axel C.

doi:10.1016/j.numecd.2016.08.006

Cited by 8 publications

(3 citation statements)

References 127 publications

(185 reference statements)

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“…This indicates that an anti-inflammatory effect i.e. of selenium also may protect against protein glycation, which has previously been discussed in the literature [29].…”

Section: Glycation Productssupporting

confidence: 70%

Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden

et al. 2022

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Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac function, less cardiac wall tension and reduced cardiovascular mortality up to 12 years of follow-up. Here we briefly review the main results, including those from studies on biomarkers related to cardiovascular risk that were subsequently conducted. In an effort, to explain underlying mechanisms, we conducted a structured analysis of the inter-relationship between biomarkers. Methods Selenium yeast (200 µg/day) and coenzyme Q10 (200 mg/ day), or placebo was given to 443 elderly community-living persons, for 48 months. Structural Equation Modelling (SEM) was used to investigate the statistical inter-relationships between biomarkers related to inflammation, oxidative stress, insulin-like growth factor 1, expression of microRNA, fibrosis, and endothelial dysfunction and their impact on the clinical effects. The main study was registered at Clinicaltrials.gov at 30th of September 2011, and has the identifier NCT01443780. Results In addition to positive clinical effects, the intervention with selenium and coenzyme Q10 was also associated with favourable effects on biomarkers of cardiovascular risk. Using these results in the SEM model, we showed that the weights of the first-order factors inflammation and oxidative stress were high, together forming a second-order factor inflammation/oxidative stress influencing the factors, fibrosis (β = 0.74; p < 0.001) and myocardium (β = 0.65; p < 0.001). According to the model, the intervention impacted fibrosis and myocardium through these factors, resulting in improved cardiac function and reduced CV mortality. Conclusion Selenium reduced inflammation and oxidative stress. According to the SEM analysis, these effects reduced fibrosis and improved myocardial function pointing to the importance of supplementation in those low on selenium and coenzyme Q10.

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“…This indicates that an anti-inflammatory effect i.e. of selenium also may protect against protein glycation, which has previously been discussed in the literature [29].…”

Section: Glycation Productssupporting

confidence: 70%

Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden

et al. 2022

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“…1 and Table 3) with incident PAD. Of interest, low levels of fructosamine have been reported to be associated with increased risk of mortality [15,36] and heart failure [15]. Several mechanisms might partly explain these associations.…”

Section: Discussionmentioning

confidence: 99%

Traditional and nontraditional glycemic markers and risk of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study

et al. 2018

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“…For example, assays for hemoglobin A1c and plasma fructosamine are standard clinical protocols of long-term blood glucose control in diabetes and renal failure, [5,6] while removal of the elevated fructosamine content in proteins may help to control development of diabetic complications. [2] Other examples of potential clinical relevance of fructosamine and other ketosamines include mortality risk from advanced cancer [7,8] and intestinal infections by Salmonella. [9] In food sciences, the Maillard reaction is recognized as one of the main sources of chemical changes occurring in foods upon thermal processing and dehydration.…”

mentioning

confidence: 99%

Synthesis and structural studies of 1-amino-1-deoxy-α-L-xylo-hexulopyranose: L-Sorbosamine

Mossine

Byrne

Barnes

et al. 2018

Journal of Carbohydrate Chemistry

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Ketosamines are an important class of glycoconjugates widely employed in clinical diagnostics and implicated in development of diabetic complications, intestinal infections, or advanced cancer, as well as in food organoleptic and nutritional value. We report on the first preparation and structural characterization of 1-amino-1-deoxy-L-sorbose (L-sorbosamine, L-SorNH 2). The monosaccharide was synthesized from L-sorbose following a classic phenylosazone protocol. In aqueous solution, L-SorNH 2 assumes an anomeric equilibrium consisting of 89.3% α-pyranose, 3.7% β-pyranose, 3.8% α-furanose, 2.4% β-furanose, and 0.9% acyclic keto tautomer. The α-pyranose anomer in crystalline L-SorNH 2 × HCl adopts the 2 C 5 chair conformation, with bond lengths and valence angles comparing well with related sorbopyranose structures. All hydroxyl oxygen atoms, the ammonium group and chloride ion are involved in an extensive hydrogen bonding network which is formed by infinite chains with fused antidromic R 7 6 (14), R 5 4 (10), and R 4 3 (8) cycles. The Hirshfeld surface analysis suggests a significant contribution of the non-polar intermolecular contacts to the crystal structure, as well.

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Low fructosamine and mortality – A long term follow-up of 215,011 non-diabetic subjects in the Swedish AMORIS study

Cited by 8 publications

References 127 publications

Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden

Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden

Traditional and nontraditional glycemic markers and risk of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study

Synthesis and structural studies of 1-amino-1-deoxy-α-L-xylo-hexulopyranose: L-Sorbosamine

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