Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats

Cao, Hui; Kuang, Yifang; Liu, Yang; Wang, Yi; Xu, Zhenghao; Gao, Feng; Zhang, Shihong; Ding, Meiping; Chen, Zhong

doi:10.1038/aps.2015.45

Cited by 9 publications

(8 citation statements)

References 53 publications

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“…Low but not high frequency stimulation of GPe has a neuroprotective preventive effect in an amygdala-kindling model in rats with less than half of the rats (43%) showing fully kindled symptoms compared to high frequency simulated rats (89%) and control group (100%). Furthermore, the cumulative after-discharge duration and generalized seizure duration in the low frequency stimulated group was significantly shorten compared to the high frequency or control group (Cheng et al 2015). These effects were suggested to be mediated through a normalization of the oscillatory power in the amygdala via the NAcc.…”

Section: Introductionmentioning

confidence: 94%

“…Interestingly, albeit smaller, comparable neuroprotective effects were found with injections into the SNr and the striatum (Klitgaard et al 2003). The GPe that receives direct GABAergic projection from the NAcc seems to also play a major role in the control of TLE (Cheng et al 2015; Robertson and Jian 1995). Low but not high frequency stimulation of GPe has a neuroprotective preventive effect in an amygdala-kindling model in rats with less than half of the rats (43%) showing fully kindled symptoms compared to high frequency simulated rats (89%) and control group (100%).…”

Section: Introductionmentioning

confidence: 99%

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The role of the basal ganglia in the control of seizure

Vuong

Devergnas

2017

J Neural Transm

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Epilepsy is a network disorder and each type of seizure involves distinct cortical and subcortical network, differently implicated in the control and propagation of the ictal activity. The role of the basal ganglia has been revealed in several cases of focal and generalized seizures. Here, we review the data that show the implication of the basal ganglia in absence, temporal lobe, and neocortical seizures in animal models (rodent, cat, and non-human primate) and in human. Based on these results and the advancement of deep brain stimulation for Parkinson's disease, basal ganglia neuromodulation has been tested with some success that can be equally seen as promising or disappointing. The effect of deep brain stimulation can be considered promising with a 76% in seizure reduction in temporal lobe epilepsy patients, but also disappointing, since only few patients have become seizure free and the antiepileptic effects have been highly variable among patients. This variability could probably be explained by the heterogeneity among the patients included in these clinical studies. To illustrate the importance of specific network identification, electrophysiological activity of the putamen and caudate nucleus has been recorded during penicillin-induced pre-frontal and motor seizures in one monkey. While an increase of the firing rate was found in putamen and caudate nucleus during pre-frontal seizures, only the activity of the putamen cells was increased during motor seizures. These preliminary results demonstrate the implication of the basal ganglia in two types of neocortical seizures and the necessity of studying the network to identify the important nodes implicated in the propagation and control of each type of seizure.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The role of the basal ganglia in the control of seizure

Vuong

Devergnas

2017

J Neural Transm

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“…Some studies described LFS induces a transient synaptic depression that alters synaptic transmission [45]. Further, LFS in the GPe exerts therapeutic effect on seizures due to interference with delta rhythms [78]. LFS could modulate cortical oscillations with statedependent [79].…”

Section: Mechanism Of Low Frequency Dbsmentioning

confidence: 99%

Mechanisms of Deep Brain Stimulation for Epilepsy and Associated Comorbidities

Deng¹,

Luan²

2017

Neuropsychiatry

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Deep brain stimulation (DBS) is an important effective treatment for pharmacoresistant epilepsy, but its mechanism is still not clear. In clinical application, the possible effects and mechanisms DBS in treatment of epilepsy are different according to different stimulation parameters. We reviewed the mechanisms of DBS in different frequencies including high frequency and low frequency in the treatment of epilepsy, covering the inhibition or excitation of synaptic, pathological neuronal and network activity, pathological rhythms or oscillation and neurotransmitter systems. As the onset and progression of seizure, it's more frequent accompanied with cognitive and psychiatric comorbidities in patients with epilepsy. We review the possible mechanism of DBS in treating epilepsy associated comorbidities including cognitive and memory disorders. With the further development of clinical application and basic research of DBS, the processing of clinical individualized therapy of DBS in epilepsy and evaluation of effects of DBS in associated comorbidities may contribute to extend the understanding of the mechanisms of DBS for epilepsy and associated comorbidities.

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“…Structures such as the amygdala may be more susceptible to kindling than other structures such as the hippocampus 29 . In addition, in the present study, LFS was applied at the primary focus instead of a secondary focus, because (1) the locations and numbers of PTS events are always unpredictable in a clinical setting 4 , 5 , 30 , (2) LFS targeted outside of the seizure focus showed promising anti-epileptogenic effects 16 , 17 , (3) LFS targeting the primary focus may provide wider coverage of anti-epileptic effects and less additionally invasive lesions. Taken together, these conjectures indicated that LFS targeting the primary focus is a promising approach to inhibit PTS at multiple secondary foci.…”

Section: Discussionmentioning

confidence: 99%

Low-frequency stimulation of the primary focus retards positive transfer of secondary focus

Kuang

Zhang

et al. 2017

Sci Rep

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Positive transfer of secondary focus (PTS) refers to new epileptogenesis outside the primary focus and is minimally controlled by existing treatments. Low-frequency stimulation (LFS) has benefits on the onset of epilepsy and epileptogenesis. However, it’s unclear whether LFS can retard the PTS in epilepsy. Here we found that PTS at both contralateral amygdala and ipsilateral hippocampus were promoted after the primary focus was fully kindled in rat kindling model. The promotion of PTS at the mirror focus started when the primary kindling acquisition reached focal seizures. LFS retarded the promotion of PTS when it was applied at the primary focus during its kindling acquisition, while it only slightly retarded the promotion of PTS when applied after generalized seizures. Meanwhile, we found the expression of potassium chloride cotransporter 2 (KCC2) decreased during PTS, and LFS reversed this. Further, the decreased expression of KCC2 was verified in patients with PTS. These findings suggest that LFS may be a potential therapeutic approach for PTS in epilepsy.

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Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats

Cited by 9 publications

References 53 publications

The role of the basal ganglia in the control of seizure

The role of the basal ganglia in the control of seizure

Mechanisms of Deep Brain Stimulation for Epilepsy and Associated Comorbidities

Low-frequency stimulation of the primary focus retards positive transfer of secondary focus

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