2016
DOI: 10.1097/wnr.0000000000000589
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Abstract: Long-term potentiation and long-term depression (LTD) are cellular mechanisms of learning and memory in the mammalian brain. We have previously shown that adult hyperthyroid rats showed a delay in the acquisition of a place learning task and attenuated long-term potentiation. However, changes in LTD in hyperthyroidism remain unclear. Rats were administered 0.2 mg/kg/day of L-thyroxine for 21 days starting at postnatal day 40 to induce hyperthyroidism. LTD was induced in the dentate gyrus using low-frequency st… Show more

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Cited by 11 publications
(5 citation statements)
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References 35 publications
(46 reference statements)
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“…[ 39 ] The patient's SOD and GSH-Px levels were relatively low, indicating that the antioxidant capacity was damaged, and required repair. [ 40 ] One of the most commonly used antithyroid drugs is thiamazole, which inhibits peroxidase in the thyroid gland and inhibits the synthesis of thyroxine (T4) and triiodothyronine (T3), but many side effects may affect its therapeutic effect. TWP is known as “Chinese herbal hormone” and its anti-immune effect may be consistent with the mechanism in modern pharmacology.…”
Section: Discussionmentioning
confidence: 99%
“…[ 39 ] The patient's SOD and GSH-Px levels were relatively low, indicating that the antioxidant capacity was damaged, and required repair. [ 40 ] One of the most commonly used antithyroid drugs is thiamazole, which inhibits peroxidase in the thyroid gland and inhibits the synthesis of thyroxine (T4) and triiodothyronine (T3), but many side effects may affect its therapeutic effect. TWP is known as “Chinese herbal hormone” and its anti-immune effect may be consistent with the mechanism in modern pharmacology.…”
Section: Discussionmentioning
confidence: 99%
“…Impaired LTP has been reported in LT 4 treated rats (Pavlides et al, 1991; Taşkin et al, 2011) or hypothyroidism rats (Alzoubi et al, 2009; Artis et al, 2012). Hypothyroidism facilitates LTD (Alzoubi et al, 2007) while adult-onset hyperthyroidism causes a durable LTD in perforant pathway-dentate gyrus synapses in rats (Tan et al, 2016). One study has reported that acute intra-hippocampal infusion of LT 4 can promote LTD over LTP via the integrin αvβ3 receptor (Bitiktas et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…The authors concluded that the activity of p38α MAPK in the astrocyte contributes to hippocampal NMDA-dependent LTD, and is capable of modulating long-term memory in vivo [39]. Another study investigated the changes in the mRNA expression levels of p38 MAPK, demonstrating its implication in the induction of LTD in response to low-frequency stimulation (LFS) [40]. The requirement of p38 MAPK for the expression of NMDA-dependent LTD was also suggested in other brain circuits using entorhinal cortex slices, where the application of the SB203580 MAPK inhibitor completely suppressed LFS-induced LTD in superficial layer II [41].…”
Section: P38 Mapk and Synaptic Functionmentioning
confidence: 99%